PAX6
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Official Full Name
paired box 6
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Overview
This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
PAX6; paired box 6; AN; AN2; MGDA; WAGR; D11S812E; paired box protein Pax-6; oculorhombin; aniridia type II protein; paired box homeotic gene-6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Arg
- GST
- His
- Fc
- Avi
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PAX6 involved in several pathways and played different roles in them. We selected most pathways PAX6 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Signaling pathways regulating pluripotency of stem cells | SMAD9;FZD7;ESX1;APC;SMAD3;GSK3B;WNT8B;MYF5;WNT5A |
Maturity onset diabetes of the young | PKLR;HHEX;HES1;INS2;HNF4A;HNF4G;MAFA;MNX1;INS |
PAX6 has several biochemical functions, for example, DNA binding, R-SMAD binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX6 itself. We selected most functions PAX6 had, and list some proteins which have the same functions with PAX6. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | TOP3B;HIST2H2AC;CRSP7;POLR1C;TIGD1;XPC;TCEB3C;HOXD3;ZNF84 |
R-SMAD binding | ZC3H3;PPM1A;MEN1;CTNNB1;PMEPA1;AXIN1;SMAD3;SMAD2;ZEB2 |
RNA polymerase II core promoter sequence-specific DNA binding | TAL1;SMAD5;GATA3;TCF7L2;MAZ;TP53;RBPJ;NR4A2;TBR1 |
RNA polymerase II transcription factor activity, sequence-specific DNA binding | HOXA13A;RUNX2;CC2D1A;ZNF446;SIM2;FOXD2;EF1;ETV5A;FOXA2 |
histone acetyltransferase binding | EPAS1;TP53;KAT2B;CREB1;SP1;EID1;MEF2A;PAX6;TAF7L |
protein binding | MT1X;RAB11A;CYFIP1;RAB33A;ADAMTS13;QKI;FOXN3;DBC1;CXCL11 |
protein kinase binding | GATA4;BAD;HIF1A;PXN;THY1;CCND3;TBC1D14;FAM83A;TCTN2 |
transcription factor activity, sequence-specific DNA binding | HOXC4;EGR4;KDM5B;EGR2B;NFYC;PBX1;NTNG1;ZNF773;KLF3 |
transcription factor binding | PDX1;DIP2B;PER1;CTBP1;HDAC11;SIX2;NKX2;UBE2I;EP300 |
ubiquitin-protein transferase activity | ZNRF1;DTX3L;UBE2N;UBE2G1;UBE2E3;PDZRN3B;TRIM21;HERC2;BIRC5 |
PAX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX6.
Dlg4; IPO13; Dynll1; TRIM11; HOMER3; NKIRAS2; EPB41L2; PCNT; APOB; MARCKSL1; GMPS; UBE2M; RAN; TRAP1; UBE2V1
Research Area
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