• Official Full Name

    paired box 6

  • Overview

    This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms

    PAX6; paired box 6; AN; AN2; MGDA; WAGR; D11S812E; paired box protein Pax-6; oculorhombin; aniridia type II protein; paired box homeotic gene-6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • Arg
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PAX6-29055TH Recombinant Human PAX6 E.coli N/A 209 amino acids
Human PAX6-134H Recombinant Human PAX6 protein, Arginine-tagged E.coli Arg
Human PAX6-130H Recombinant Human PAX6 E.coli N/A
Human PAX6-148H Recombinant Human PAX6 Protein, His-tagged E.coli His
Human PAX6-3415HCL Recombinant Human PAX6 293 Cell Lysate HEK293 N/A
Human PAX6-1803H Recombinant Human PAX6 protein, GST-tagged E.coli GST 126-229 aa
Human PAX6-4800H Recombinant Human PAX6 Protein (Met1-Arg272), N-His tagged E.coli N-His Met1-Arg272
Human PAX6-8732H Recombinant Human PAX6 protein(1-422aa), His-tagged E. coli N-His 1-422aa
Rat PAX6-4284R Recombinant Rat PAX6 Protein Mammalian Cell His
Rat PAX6-3946R-B Recombinant Rat PAX6 Protein Pre-coupled Magnetic Beads HEK293
Rat PAX6-3946R Recombinant Rat PAX6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Pax6-764R Recombinant Rat Pax6 Protein, His-tagged E.coli His Met1~Leu130
Rhesus Macaque PAX6-3312R Recombinant Rhesus monkey PAX6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PAX6-3130R Recombinant Rhesus Macaque PAX6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PAX6-3130R-B Recombinant Rhesus Macaque PAX6 Protein Pre-coupled Magnetic Beads HEK293
Chicken PAX6-6623C Recombinant Chicken PAX6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PAX6 involved in several pathways and played different roles in them. We selected most pathways PAX6 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling pathways regulating pluripotency of stem cellsOTX1;ACVR1;WNT10B;AKT2;APC;FGFR4;WNT2B;NRAS;AXIN1
Maturity onset diabetes of the youngINS1;HHEX;FOXA2;RFX6;BHLHA15;HES1;INS2;HNF1B;MAFA

PAX6 has several biochemical functions, for example, DNA binding, R-SMAD binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX6 itself. We selected most functions PAX6 had, and list some proteins which have the same functions with PAX6. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter sequence-specific DNA bindingHOXB3;SUZ12;PAX8;FOS;TP53;H2AFY;GBX2;YAP1;STAT5A
RNA polymerase II transcription factor activity, sequence-specific DNA bindingEOMESA;TP73;OVOL3;JUND;FOXA1;FLI1B;ZNF215;SPI1A;FOXI3B
histone acetyltransferase bindingMYOCD;SP1;PCNA;EID1;TRIM68;MTF1;EPAS1;ETS1;TAF7
protein kinase bindingBCL2L1;STK39;MSN;RAD9A;PLCG1;PPP1R15A;CCNY;FAF1;PTPRR
transcription factor activity, sequence-specific DNA bindingHMG20A;ZBTB48;ZFP770;ELK4;DBPA;FOXE3;NR3C1;HOXC4A;EGR2A
transcription factor bindingTFDP1;ARRB1;ERCC3;PIAS2;CAMTA2;MAPK1;APBB3;CRY1;TCF12
ubiquitin-protein transferase activityRNF6;FBXL21;FBXL3;RNF182;UBE2O;TRIM71;UBE2K;TRIM62;TRIM27

PAX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX6.


Research Area

Related articles

Toriyama, A; Mori, T; et al. Utility of PAX8 mouse monoclonal antibody in the diagnosis of thyroid, thymic, pleural and lung tumours: a comparison with polyclonal PAX8 antibody. HISTOPATHOLOGY 65:465-472(2014).
Diaz-Balzac, CA; Vazquez-Figueroa, LD; et al. Novel markers identify nervous system components of the holothurian nervous system. INVERTEBRATE NEUROSCIENCE 14:113-125(2014).
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