This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically;contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development.;This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral;column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene.;Mutations in this gene are also associated with vertebral malformations.
PAX1 has several biochemical functions, for example, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX1 itself. We selected most functions PAX1 had, and list some proteins which have the same functions with PAX1. You can find most of the proteins on our site.
Function DNA binding
Related Protein HMGB2; ISL2B; ZNF404; KDM2BA; BEND5; PUF60; ZNF136; RPAP1; TBX10; FOXQ2