PAX2
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Official Full Name
paired box 2
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Overview
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] -
Synonyms
PAX2; paired box 2; PAPRS; paired box protein Pax-2; paired box homeotic gene 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PAX2 Related Articles
- PAX2 Related Research Area
PAX2 involved in several pathways and played different roles in them. We selected most pathways PAX2 participated on our site, such as Id Signaling Pathway, Wnt Signaling Pathway NetPath, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Id Signaling Pathway | MYF6;MYOD1;ELK3;TCF3B;MSC;KDR;TCF12;MYOG;ACVRL1 |
Wnt Signaling Pathway NetPath | HIPK2;MARK2;MTAP1B;TFAP2A;MAP1B;CSNK2A1P;CRYBB2;PAX2;BRD7 |
PAX2 has several biochemical functions, for example, DNA binding, core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX2 itself. We selected most functions PAX2 had, and list some proteins which have the same functions with PAX2. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | SPRTN;ZFAND5;ENG2A;MSXC;EOMESA;GFI1B;HOXA13A;HOXB1B;TET3 |
core promoter proximal region sequence-specific DNA binding | SP3A;DMRTC2;SMAD4;DMRT2A;PAX2;DMRT2;KLF4;MEF2C;DMRTC1B |
protein binding | CLEC4G;DVL2;SMAD9;AMDHD2;DDIT3;USE1;ICAM4;FGD2;PHF23 |
superoxide-generating NADPH oxidase activity | NOX5;PAX2;NOX3;NOX4;CYBB;SH3PXD2AA;NOX1;NCF1 |
transcription factor binding | PIANP;IGHMBP2;TBP;PER1;AGTR2;ZFPM2;SIRT2;ESR1;STK36 |
transcription regulatory region DNA binding | MTERFD1;TBX21;TOMM20A;RCOR1;RFX6;TAF2;RREB1;AHR;CITED1 |
PAX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX2.
BBS7; BBS1; BBS4; BBS2; GLCE; SNAI1; TRIM25; IL13RA2; BLID; KLK6; RASL10B; WHSC1L1; PRDM14; BEX1; VPS45; MRC2
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