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PAX2

  • Official Full Name

    paired box 2

  • Overview

    PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
  • Synonyms

    PAX2; paired box 2; PAPRS; paired box protein Pax-2; paired box homeotic gene 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PAX2-1539H Recombinant Human PAX2, GST-tagged E.coli GST
Human PAX2-315H Recombinant Human PAX2 Mammalian Cell His
Human PAX2-3419HCL Recombinant Human PAX2 293 Cell Lysate HEK293 N/A
Human PAX2-942H Recombinant Human PAX2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PAX2-5598H Recombinant Human PAX2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PAX2-3800H-B Recombinant Human PAX2 Protein Pre-coupled Magnetic Beads HEK293
Human PAX2-5570H Recombinant Human PAX2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PAX2-5271H Recombinant Human PAX2 protein, GST-tagged E.coli GST 1-388aa
Human PAX2-3800H Recombinant Human PAX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PAX2-12391M Recombinant Mouse PAX2 Protein Mammalian Cell His
Mouse PAX2-6516M Recombinant Mouse PAX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PAX2-6516M-B Recombinant Mouse PAX2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Pax2-4684M Recombinant Mouse Pax2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Chicken PAX2-6356C Recombinant Chicken PAX2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PAX2 Related Articles
  • PAX2 Related Research Area

PAX2 involved in several pathways and played different roles in them. We selected most pathways PAX2 participated on our site, such as Id Signaling Pathway, Wnt Signaling Pathway NetPath, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Id Signaling PathwayMYOD1;ELK3;IFI16;PAX2;MSC;TCF3B;MYF6;MYOG;ACVRL1
Wnt Signaling Pathway NetPathBRD7;TCF4;ANKRD6;MARK2;TAX1BP3;CRYBB2;SOX1;BCL9;HIPK2

PAX2 has several biochemical functions, for example, DNA binding, core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX2 itself. We selected most functions PAX2 had, and list some proteins which have the same functions with PAX2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZC3H3;SMYD1;VPS72;ZFP524;CHD6;MNDA;TOX4;TCEB3C;HIST1H2AK
core promoter proximal region sequence-specific DNA bindingSMAD4;DMRTC1C2;DMRT3A;GATA3;PAX2;TFAP2A;KLF1;SMAD3;DMRT3
protein bindingF10;RGS19;NTRK3;BMPR1AA;HCK;PDGFB;IFITM3;RXRB;C16orf53
superoxide-generating NADPH oxidase activitySH3PXD2AA;NOX1;NOX3;PAX2;NOX5;NCF1;CYBB;NOX4
transcription factor bindingINSIG2;THRA;DRAP1;TFDP1;RNF19A;TRIM6;E2F1;HES6;STK4
transcription regulatory region DNA bindingMEF2C;RCOR1;HNF4A;TFE3;SMAD4;SALL1A;MTERF3;ZNF567;GABPA

PAX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX2.

BBS7; BBS1; BBS4; BBS2; GLCE; SNAI1; TRIM25; IL13RA2; BLID; KLK6; RASL10B; WHSC1L1; PRDM14; BEX1; VPS45; MRC2

Stewart, CJR; Crook, ML; et al. PAX2 and Cyclin D1 Expression in the Distinction Between Cervical Microglandular Hyperplasia and Endometrial Microglandular-like Carcinoma: A Comparison With p16, Vimentin, and Ki67. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY 34:90-100(2015).
Gutierrez-Mecinas, M; Watanabe, M; et al. Expression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn. MOLECULAR PAIN 10:-(2014).
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