"SIRT2" Related Products

Expand
Expand
Expand

Recombinant Human SIRT2, His-tagged

Cat.No.: SIRT2-31405TH
Product Overview: Recombinant full length Human SIRT2 fused at the N-terminus to a His-tag, 45kDa.
Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
Protein length: 388 amino acids
Conjugation: HIS
Molecular Weight: 45.000kDa inclusive of tags
Source: E. coli
Tissue specificity: Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulatio
Biological activity: HDAC activity.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 50mM Tris HCl, 100mM Sodium chloride, pH 8.2
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.
Gene Name: SIRT2 sirtuin 2 [ Homo sapiens ]
Official Symbol: SIRT2
Synonyms: SIRT2; sirtuin 2; SIR2L, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; NAD-dependent deacetylase sirtuin-2;
Gene ID: 22933
mRNA Refseq: NM_001193286
Protein Refseq: NP_001180215
MIM: 604480
Uniprot ID: Q8IXJ6
Chromosome Location: 19q13
Pathway: Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem;
Function: NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.