Recombinant Human SIRT2 Protein, His-tagged

• Cat.No.: SIRT2-107H
• Product Overview: Active recombinant N-terminal His-tagged human SIRT2 protein (2-389) was purified from E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 2-389
• Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
• Molecular Mass: 44.2 kDa
• Purity: ≥90% as determined by SDS-PAGE
• Unit Definition: One unit is defined as the amount of enzyme required to produce 1 nmol of 7-amino-4-methylcouarin per minute at 25 centigrade in 50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, containing 125 μM p53 amino acids 317-320 (Gln-Pro-Lys-Lys(e-acetyl)-AMC), and 6 mM NAD+.
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol

Gene Information

• Gene Name: SIRT2 sirtuin 2 [ Homo sapiens (human) ]
• Official Symbol: SIRT2
• Synonyms: SIRT2; sirtuin 2; SIR2; SIR2L; SIR2L2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent deacetylase sirtuin-2; SIR2-like protein 2; regulatory protein SIR2 homolog 2; silent information regulator 2; sir2-related protein type 2; sirtuin type 2; EC 2.3.1.286
• Gene ID: 22933
• mRNA Refseq: NM_012237
• Protein Refseq: NP_036369
• MIM: 604480
• UniProt ID: Q8IXJ6