Recombinant Human SIRT3, His-tagged
Cat.No. : | SIRT3-30594TH |
Product Overview : | Recombinant fragment of Human SIRT3 with N terminal His tag; 303aa, 33.5kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. |
Protein length : | 282 amino acids |
Conjugation : | HIS |
Molecular Weight : | 33.500kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | Widely expressed. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMSDKG KLSLQDVAELIRARACQRVVVMVGA GISTPSGIPDFRSPGSGLYSNLQQY DLPYPEAIFELPFFF HNPKPFFTLAKELYPGNYKPNVTHY FLRLLHDKGLLLRLYTQNIDGLERV SGIPASKLVEAHGTFASATCTVCQR PFPGEDIRADVMADRVPRCPVCTGV VKPDIVFFGEPLPQRFLLHVVDFPM ADLLLILGTSLEVEPFASLTEAVRS SVPRLLINRDLVGPLAWHPRSRDVA QLGDVVHGVESLVELLGWTEEMRDL VQRETGKLDGPDK |
Sequence Similarities : | Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain. |
Gene Name : | SIRT3 sirtuin 3 [ Homo sapiens ] |
Official Symbol : | SIRT3 |
Synonyms : | SIRT3; sirtuin 3; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; NAD-dependent deacetylase sirtuin-3, mitochondrial; SIR2L3; |
Gene ID : | 23410 |
mRNA Refseq : | NM_001017524 |
Protein Refseq : | NP_001017524 |
MIM : | 604481 |
Uniprot ID : | Q9NTG7 |
Chromosome Location : | 11p15.5 |
Pathway : | Energy Metabolism, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem; |
Function : | NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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