Recombinant Human SIRT3 Protein, His-tagged SIRT3-28H

Recombinant Human SIRT3 Protein, His-tagged

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Recombinant Human SIRT3 Protein, His-tagged

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Cat.No. : SIRT3-28H
Product Overview : Recombinant human SIRT3(101-399) protein with a N-terminal His-tag was expressed in E. coli.
Description : SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 37 kDa (theoretical); 33.5 kDa (observed)
Protein length : 101-399
Purity : ≥60% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to produce 1 nmole of 7-amino-4-methylcoumarin per minute at 25 centigrade in 50 mM Tris-HCl, pH 8.0, containing 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 125 μM p53 amino acids 317-320 (Gln-Pro-Lys-Lys(e-acetyl)-AMC), and 6 mM NAD+.
Stability : ≥ 9 months
Storage : Store it at -80 centigrade
Storage Buffer : 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol
SDS-PAGE Analysis of SIRT3 :

Lane 1: MW Markers; Lane 2: SIRT3 (5 μg); Lane 3: SIRT3 (2.5 μg); Lane 4: SIRT3 (1.25 μg). Representative gel image shown; actual purity may vary between each batch but protein will be ≥50% pure.

Inhibition of SIRT3 activity by Nicotinamide :

Gene Name : SIRT3 sirtuin 3 [ Homo sapiens (human) ]
Official Symbol : SIRT3
Synonyms : SIRT3; sirtuin 3; SIR2L3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; NAD-dependent deacetylase sirtuin-3, mitochondrial; SIR2-like protein 3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; regulatory protein SIR2 homolog 3; silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; sirtuin type 3
Gene ID : 23410
mRNA Refseq : NM_001017524
Protein Refseq : NP_001017524
MIM : 604481
UniProt ID : Q9NTG7

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