Recombinant Human SIRT1, His-tagged

• Cat.No.: SIRT1-658H
• Product Overview: Recombinant Human SIRT1 is produced from human cDNA, expressed in E. coli. Sequence identical to that at Genbank accession #NM012238.

Specification

• Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 25 mM TRIS, pH 7.5, 100mM NaCl, 5mM DTT and 10% glycerol.
• Molecular Mass: 82 kDa
• Storage: -80°C

Gene Information

• Gene Name: SIRT1 sirtuin 1 [ Homo sapiens (human) ]
• Official Symbol: SIRT1
• Synonyms: SIRT1; SIR2L1; sirtuin 1; NAD-dependent protein deacetylase sirtuin-1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; NAD-dependent deacetylase sirtuin-1
• Gene ID: 23411
• mRNA Refseq: NM_001142498
• Protein Refseq: NP_001135970
• MIM: 604479
• UniProt ID: Q96EB6
• Chromosome Location: 10q21.3
• Pathway: Amphetamine addiction; E2F transcription factor network; Energy Metabolism
• Function: HLH domain binding; NOT NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity