Recombinant Human AR Protein, Sumo/His/Strep-tagged AR-003H

Recombinant Human AR Protein, Sumo/His/Strep-tagged

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Cat.No. : AR-003H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human AR Protein (1-669) with Sumo/His/Strep tag was expressed in E. coli.
Description : The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : E. coli
Species : Human
Tag : Sumo/His/Strep
Molecular Mass : 84.13 kDa
AA Sequence : MNWSHPQFEK SSGSSGGHHH HHHGGSGGSG SDSEVNQEAK PEVKPEVKPE THINLKVSDG SSEIFFKIKK TTPLRRLMEA FAKRQGKEMD SLRFLYDGIR IQADQAPEDL DMEDNDIIEA HREQIGGMEV QLGLGRVYPR PPSKTYRGAF QNLFQSVREV IQNPGPRHPE AASAAPPGAS LLLLQQQQQQ QQQQQQQQQQ QQQQQQQETS PRQQQQQQGE DGSPQAHRRG PTGYLVLDEE QQPSQPQSAL ECHPERGCVP EPGAAVAASK GLPQQLPAPP DEDDSAAPST LSLLGPTFPG LSSCSADLKD ILSEASTMQL LQQQQQEAVS EGSSSGRARE ASGAPTSSKD NYLGGTSTIS DNAKELCKAV SVSMGLGVEA LEHLSPGEQL RGDCMYAPLL GVPPAVRPTP CAPLAECKGS LLDDSAGKST EDTAEYSPFK GGYTKGLEGE SLGCSGSAAA GSSGTLELPS TLSLYKSGAL DEAAAYQSRD YYNFPLALAG PPPPPPPPHP HARIKLENPL DYGSAWAAAA AQCRYGDLAS LHGAGAAGPG SGSPSAAASS SWHTLFTAEE GQLYGPCGGG GGGGGGGGGG GGGGGGGGGG EAGAVAPYGY TRPPQGLAGQ ESDFTAPDVW YPGGMVSRVP YPSPTCVKSE MGPWMDSYSG PYGDMRLETA RDHVLPIDYY FPPQKTCLIC GDEASGCHYG ALTCGSCKVF FKRAAEGKQK YLCASRNDCT IDKFRRKNCP SCRLRKCYEA GMTLGARKLK KLGNLKLQEE GEASSTTSPT EETTQKLTVS HIEGYE
Purity : > 85% by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 0.5 mg/mL
Storage Buffer : Supplied as a 0.2 μm filtered solution in PBS, pH 7.4.
SDS-PAGE :

M: Protein Marker
1: 0.5 mg/mL BSA
2: AR

M: Protein Marker
1: AR

Gene Name : AR androgen receptor [ Homo sapiens (human) ]
Official Symbol : AR
Synonyms : AR; androgen receptor; KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA; androgen receptor; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4
Gene ID : 367
mRNA Refseq : NM_000044
Protein Refseq : NP_000035
MIM : 313700
UniProt ID : P10275
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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