AR Protein

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Home / Products / AR


Official Full Name androgen receptor
Background The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Synonyms AR; androgen receptor; KD; AIS; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA; dihydrotestosterone receptor; androgen nuclear receptor variant 2; nuclear receptor subfamily 3 group C member 4;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • His
    • GST
    • SUMO
    • Myc
    • N/A
    • Sumo/His/Strep
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AR-17H Recombinant Human AR, His-tagged E.coli His
    Human AR-27312TH Recombinant Human AR, Flag-tagged Insect Cell Flag
    Human AR-991H Recombinant Human AR protein, His-tagged E.coli His
    Human AR-992H Recombinant Human AR protein, His/Sumo/Myc-tagged E.coli His/SUMO/Myc
    Human AR-1012H Recombinant Human AR, His-tagged E.coli His
    Human AR-101H Recombinant Human Androgen receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
    Human AR-2622H Recombinant Human Androgen Receptor, His-tagged E.coli His
    Human AR-737H Recombinant Human AR protein, GST-tagged Wheat Germ GST
    Human AR-9788H Recombinant Human AR, His-tagged E.coli His
    Mouse Ar-3451M Recombinant Mouse Ar, His-tagged E.Coli or Yeast His
    Mouse Ar-6724M Recombinant Mouse Ar protein, His & GST-tagged E.coli His/GST
    Rat Ar-6725R Recombinant Rat Ar protein, His-tagged E.coli His
    Rat Ar-6726R Recombinant Rat Ar protein, His-tagged E.coli His
    Rat AR-743R Recombinant Rat AR Protein Mammalian Cell His
    Rhesus Macaque AR-375R Recombinant Rhesus monkey AR Protein, His-tagged Mammalian Cell His
    Chicken AR-3407C Recombinant Chicken AR Mammalian Cell His
    Zebrafish AR-5400Z Recombinant Zebrafish AR Mammalian Cell His
    Human AR-8764HCL Recombinant Human AR 293 Cell Lysate HEK293 N/A
    Human AR-001H Recombinant Human Androgen Receptor protein Insect Cell
    Human AR-003H Recombinant Human AR Protein, Sumo/His/Strep-tagged E.coli Sumo/His/Strep
    Human AR-27313TH Recombinant Human AR Flag/His
    Human AR-333H Recombinant Human Androgen Receptor Protein, His-tagged Insect cells His
    CBCRY23 Androgen Receptor E.coli N/A
    Kit-1654 CHO-K1 AR Protein Interaction Assay Kit N/A

    AR involved in several pathways and played different roles in them. We selected most pathways AR participated on our site, such as Oocyte meiosis, Pathways in cancer, Prostate cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with AR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer CDC42; TFG; PLCB1; CCNE2; LAMC1; Fgf15; PPARD; FOXO1; BID; RAF1
    Prostate cancer IGF1; PTEN; CPN1; INS; ARAF; SOS1; CREB3L2; PDGFB; PIK3R3; CCNE2

    AR has several biochemical functions, for example, ATPase binding, DNA binding, POU domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AR itself. We selected most functions AR had, and list some proteins which have the same functions with AR. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding ATP1B2; TOR1AIP1; ATP1B3; FBL; S100A1; ZNHIT6; DNAJC10; ATP6V1G3; DERL1; PLN
    POU domain binding Ar
    RNA polymerase II core promoter proximal region sequence-specific DNA binding HNRNPK; JUNB; STAT3; ZKSCAN3; ELK1; ZFP639; ETS2; PBX1; NEUROD1; HSF1
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding Ar; PPARAA; NR1D2; STAT3; NR2F1; NR2F5; PTGER3; HNF4A; NR5A1B; RORAB
    RNA polymerase II transcription factor binding ID4; CREBBP; ZFPM1; GATA1A; GATA1; NFATC1; TP53; GATA2; TBX3; CHST13
    androgen binding ALDH1A1; TSPO; SHBG; Ar
    androgen receptor activity NKX3; NKX3-1; NR1I3; Ar
    androgen receptor binding CALR; FOXP1; NCOA1; NCOA3; WIPI1; PRPF6; TRIM68; PRMT2; GRIP1; PRKCB
    beta-catenin binding NF2; LEF1; CDH24; DACT1; SMAD3; GRIP1; LZTS2A; SOX9; TRPC4; NUMB
    chromatin binding WHSC1; ARID3C; BAP1; EOMES; SIRT2; RNF2; MEN1; ELK1; PHF8; CREB3
    enzyme binding ERN1; CBX4; ZFP36; H2AFX; GSTM1; JUND; EIF4E; C6orf211; HIST1H2AN; CASC3
    lipid binding BPIFA5; PAQR5A; RBP7B; APOA1A; ATP5G3; CYTH4; PTGS2; AP2M1A; DBI; S1PR2
    metal ion binding TRIM67; NR5A5; GMPR; MGRN1A; APOA1BP; MICALL2A; ACSM3; ZNF350; FOXP3; ZNF215
    protein binding DLL1; MGST1; TSG101; ELP4; SPAT-1; CTBP1; C7orf59; CDC42EP4; TRPM8; NOC2L
    protein domain specific binding RHOA; PPP3R1; PICK1; CEP68; YWHAB; GUSB; DYNLL1; PLAUR; SNCA; RAN
    receptor binding NRG2; FGF18A; FGF12B; SLC27A2; SRPX2; CADM3; FGG; NPY; AGRP2; CSNK2B
    sequence-specific DNA binding MTA3; FOXR2; NKX2.7; TAF1; BHLHE22; DMRT3; FOXQ2; NKX6.3; HOXA6; SPDEF
    steroid binding NR3C1; CYP3A4; ESRRA; ESR1; PAQR8; GPR30; ESR2B; ESRRB; NR3C2; PAQR5A
    transcription factor activity, sequence-specific DNA binding ZSCAN12; TBX18; ETV5B; DRAP1; ZNF583; HIF1AL; ZNF383; TAF5L; CARF; TCF25
    transcription factor binding PYDC3; DR1; HMGA2; IFI203; PSMC5; TCF7L2; CXXC5; PSMD4; HYAL1; RB1
    transcription regulatory region DNA binding LEF1; TP53; ZFP821; SOX5; Arid4b; SOX2; TP73; RBBP5; NKX3; MEF2C
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ESR1; FOSB; CAMTA1; TFAP2C; MITFB; GMEB1; ALS2CR8; NR3C1; SMAD4; FOS
    zinc ion binding GATAD2B; BRF1A; TRIM52; KPNB1; MYLIP; ADAMTS2; ZCCHC6; KDM5BA; RNF181; PGR

    AR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AR here. Most of them are supplied by our site. Hope this information will be useful for your research of AR.

    Wang, YY; Tang, L; et al. Multiplexed gold nanorod array biochip for multi-sample analysis. BIOSENSORS & BIOELECTRONICS 67:18-24(2015).
    Tilli, TM; Ferreira, LB; et al. Osteopontin-c mediates the upregulation of androgen responsive genes in LNCaP cells through PI3K/Akt and androgen receptor signaling. ONCOLOGY LETTERS 9:1845-1850(2015).

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