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  • Official Full Name
  • androgen receptor
  • Background
  • The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Synonyms
  • AR; androgen receptor; KD; AIS; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA; dihydrotestosterone receptor; androgen nuclear receptor variant 2; nuclear receptor subfamily 3 group C member 4;
Cat.#:AR-333HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Androgen Receptor Protein, His-tagged
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Cat.#:AR-1012HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AR, His-tagged
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Cat.#:AR-101HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Androgen receptor LBD/Hsp90 complex, GST-tagged
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Cat.#:AR-17HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AR, His-tagged
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Cat.#:AR-27312THTag:Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AR, Flag-tagged
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Cat.#:AR-737HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AR protein, GST-tagged
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Cat.#:AR-9788HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AR, His-tagged
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Cat.#:AR-991HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AR protein, His-tagged
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Cat.#:AR-992HTag:His/Sumo/Myc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AR protein, His/Sumo/Myc-tagged
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Cat.#:Ar-3451MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Ar, His-tagged
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Cat.#:Ar-6724MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ar protein, His & GST-tagged
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Cat.#:Ar-6725RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ar protein, His-tagged
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Cat.#:Ar-6726RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ar protein, His-tagged
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Cat.#:AR-743RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AR Protein
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Cat.#:AR-375RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AR Protein, His-tagged
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Cat.#:AR-3407CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AR
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Cat.#:AR-5400ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AR
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Cat.#:AR-2622HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Androgen Receptor, His-tagged
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Cat.#:AR-8764HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AR 293 Cell Lysate
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Cat.#:Kit-1654Tag:
Source (Host):Species:
Product nameCHO-K1 AR Protein Interaction Assay Kit
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Cat.#:Kit-1921Tag:
Source (Host):Species:
Product nameAR (human) Reporter Assay Kit
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Cat.#:CBCRY23Tag:
Source (Host):E. coliSpecies:
Product nameAndrogen Receptor
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Involved Pathway

AR involved in several pathways and played different roles in them. We selected most pathways AR participated on our site, such as Oocyte meiosis, Pathways in cancer, Prostate cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with AR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oocyte meiosis
ADCY1A; SKP1; AURKA; CALM2; RPS6KAL; CCNB2; PPP2R5B; BTRC; ANAPC2; PLCZ1
Pathways in cancer
CTBP2; NKX3; ABL1; PDGFRA; PIK3R3; STAT3; SMO; SOS1; PTCH2; FGF2
Prostate cancer
RELA; TCF7L2; SMARCC2; INS2; CREB3L1; BCL2; ATF4; NDRG1; CREB3L3; NKX3-1

Protein Function

AR has several biochemical functions, for example, ATPase binding, DNA binding, POU domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AR itself. We selected most functions AR had, and list some proteins which have the same functions with AR. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein TAF9; PTPN3; FAM119A; ATP6V0A1B; TCIRG1; ESR1; USP25; DRD1A; SVIP; ATPIF1B
Function DNA binding
Related Protein NKX6.1; TADA2B; MYPOP; SPI1A; ZFP574; SIX1; IRX3B; SOX3; ZNF311; NR1H3
Function POU domain binding
Related Protein Ar
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein DLX4; ZFP746; TFE3B; DDN; TBP; FOXI1; GABPA; PPARA; ZNF718; ELF3
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein NR2F5; NR2F2; PPARDB; NR2E3; NR2F1B; RORCA; RXRB; AHR2; NR4A2B; AHR
Function RNA polymerase II transcription factor binding
Related Protein SFPI1; MEF2A; GATA5; GATA1; MTA2; KLF4; GATA2A; TAL1; SMAD4; MKX
Function androgen binding
Related Protein TSPO; SHBG; Ar; ALDH1A1
Function androgen receptor activity
Related Protein NKX3-1; NKX3; Ar; NR1I3
Function androgen receptor binding
Related Protein DAXX; TCF21; GRIP1; SMARCA4; NCOA1; CTNNB1; PRPF6; RB1; EP300; Ar
Function beta-catenin binding
Related Protein DACT1; SMAD7; NUMB; CALCOCO1; SHROOM2; CTNNBIP1; CARM1; PSEN1; PTPRK; Ar
Function chromatin binding
Related Protein NIPBL; UXT; JDP2; KLHDC3; ISL1; EP300; PRKCB; SFPQ; FOS; PRIMPOL
Function enzyme binding
Related Protein SCN5A; JUN; RFC5; SELS; APOA1; HDAC2; HSPA2; HIST1H2AD; TMBIM6; YWHAE
Function lipid binding
Related Protein MELK; ACOT11; STARD8; BPIFB1; PFN4; CHMP4A; GPIHBP1; EPN1; Ar; UNC119
Function metal ion binding
Related Protein CYP2AD3; ASXL1; BMX; IKZF4; ZNF254; AMY1B; APEX1; ADCY7; ZNF319; MZF1
Function protein binding
Related Protein RPL11; LAMTOR3; AIG1; TFAP2A; ZMAT2; DCTN3; FAM46D; S100A9; MYCN; ZNF543
Function protein domain specific binding
Related Protein HMGB2; HIST1H4I; STXBP1; EFS; IKBKG; PPARA; TWIST1; MLF1; HIST1H4K; SCN5A
Function receptor binding
Related Protein NRG2; FYNA; ALCAM; PICK1; CSNK2B; FGF18A; KNG1; TNFSF13B; ADM; CADM2A
Function sequence-specific DNA binding
Related Protein FOXH1; FOXF1; NR6A1A; VENT; CREMB; ZNF192; ESR2B; FOXN2B; BCL11AA; HSF5
Function steroid binding
Related Protein ESR1; FAM84B; PAQR5B; SERPINA6; SULT1E1; ESR2A; ESRRGA; PGRMC1; HSD3B4; PAQR7
Function transcription factor activity, sequence-specific DNA binding
Related Protein FOXO4; HLFA; L3MBTL4; TTC4; SP3A; HSF4; POU5F2; DMRT3; PCGF2; FOXP3
Function transcription factor binding
Related Protein NR0B2; NBN; PPP1R13B; RNF19A; POU1F1; DIP2A; TFAP2A; SLC26A5; IFI16; TAF7
Function transcription regulatory region DNA binding
Related Protein ZNF613; FOXA2; TFAP4; ZNF567; CDK5RAP2; ATF5; TAL1; IKZF1; SALL1; Arid4b
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein NR1H4; ETV2; SMAD1; MYBL2; BCL11B; CEBPB; MTF1; TP53; MEOX2; PLSCR1
Function zinc ion binding
Related Protein ZNF259; PHF8; SLC30A8; RNF34; ADAMTS13; TRIM6; DBF4B; ANPEP; ABP1; MMP13A

AR Related Articles

Wang, YY; Tang, L; et al. Multiplexed gold nanorod array biochip for multi-sample analysis. BIOSENSORS & BIOELECTRONICS 67:18-24(2015).
Tilli, TM; Ferreira, LB; et al. Osteopontin-c mediates the upregulation of androgen responsive genes in LNCaP cells through PI3K/Akt and androgen receptor signaling. ONCOLOGY LETTERS 9:1845-1850(2015).

AR Related Gene Family

TNF Cytokines