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  • Official Full Name
  • androgen receptor
  • Background
  • The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Synonyms
  • AR; androgen receptor; KD; AIS; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA; dihydrotestosterone receptor; androgen nuclear receptor variant 2; nuclear receptor subfamily 3 group C member 4;
Cat.#:AR-1012HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AR, His-tagged
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Cat.#:AR-101HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Androgen receptor LBD/Hsp90 complex, GST-tagged
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Cat.#:AR-17HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AR, His-tagged
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Cat.#:AR-27312THTag:Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AR, Flag-tagged
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Cat.#:AR-737HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AR protein, GST-tagged
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Cat.#:AR-9788HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AR, His-tagged
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Cat.#:AR-991HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AR protein, His-tagged
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Cat.#:AR-992HTag:His/Sumo/Myc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AR protein, His/Sumo/Myc-tagged
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Cat.#:Ar-3451MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Ar, His-tagged
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Cat.#:Ar-6724MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ar protein, His & GST-tagged
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Cat.#:Ar-6725RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ar protein, His-tagged
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Cat.#:Ar-6726RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ar protein, His-tagged
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Cat.#:AR-743RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AR Protein
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Cat.#:AR-375RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AR Protein, His-tagged
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Cat.#:AR-3407CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AR
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Cat.#:AR-5400ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AR
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Cat.#:AR-2622HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Androgen Receptor, His-tagged
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Cat.#:AR-8764HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AR 293 Cell Lysate
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Cat.#:Kit-1654Tag:
Source (Host):Species:
Product nameCHO-K1 AR Protein Interaction Assay Kit
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Cat.#:Kit-1921Tag:
Source (Host):Species:
Product nameAR (human) Reporter Assay Kit
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Cat.#:CBCRY23Tag:
Source (Host):E. coliSpecies:
Product nameAndrogen Receptor
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Involved Pathway

AR involved in several pathways and played different roles in them. We selected most pathways AR participated on our site, such as Oocyte meiosis, Pathways in cancer, Prostate cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with AR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oocyte meiosis
CPEB1A; ANAPC4; CUL1; MAD2L2; YWHABL; CALM; PRKACAA; RPS6KA1; INS2; ADCY1A
Pathways in cancer
FGF19; ROCK1; PLCB2; FH; MSH3; LAMA3; FGF12; TGFB2; LPAR2; PLCG2
Prostate cancer
MAP2K1; PIK3R5; GSTP1; TCF7; PIK3CB; KRAS; CCNE1; PDPK1; ERBB2; RAF1

Protein Function

AR has several biochemical functions, for example, ATPase binding, DNA binding, POU domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AR itself. We selected most functions AR had, and list some proteins which have the same functions with AR. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein USP25; ATP6V1G1; ATXN3; EZR; ZNHIT6; METTL21A; SDF2L1; PLN; ATP6V0A1A; ATP6V0A1B
Function DNA binding
Related Protein ETV5; MEF2C; ZSCAN1; ZNF683; POLA1; MAFBA; MEIS4.1A; CRY1; FOXN4; ZFP639
Function POU domain binding
Related Protein Ar
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein FOXJ2; NOBOX; TBX15; SMAD2; TCF4; TFE3; TCF12; ESRRA; FOS; ZNF92
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein PTGER3; NR2F6B; NR2E3; PPARAA; NR2F2; RXRA; PPARAB; RORA; AHR2; NR2F1A
Function RNA polymerase II transcription factor binding
Related Protein GATA2; ZGLP1; T; ZFPM2; MTDH; SPOP; WWP2; GSC; TBX3; ANKRD1
Function androgen binding
Related Protein Ar; TSPO; ALDH1A1; SHBG
Function androgen receptor activity
Related Protein NKX3; NKX3-1; NR1I3; Ar
Function androgen receptor binding
Related Protein DAXX; CTNNB1; FOXH1; WIPI1; PARK7; GRIP1; DDX5; KAT5; Ar; RNF14
Function beta-catenin binding
Related Protein TCF7; TCF7L1A; APC2; TRPC4; MED12; MED12L; PTPRK; VCL; PTPRJ; ASH2L
Function chromatin binding
Related Protein ANKRD17; NR5A1B; EZH2; NR5A1A; JARID2; CTBP2; GATA4; HMGB3; NCOA1; TPR
Function enzyme binding
Related Protein HIST1H2AM; KPNB1; BCHE; TSPAN33; SIRT1; Ar; RYR2; GBP1; RCOR1; CYP2C8
Function lipid binding
Related Protein CYTH2; DBIL5; PLUNC; MAL; APOL6; PAQR5A; PRAM1; PTEN; FABP1B.1; AP2M1
Function metal ion binding
Related Protein AMHR2; PAPD7; FGD3; NR5A1B; TSNAX; BLF; MCM2; ZMYND17; NT5C2B; CYCS
Function protein binding
Related Protein PELP1; IFIT3; AP2B1; SNRPN; SSTR2; LCP2; TERF2IP; PRKRIP1; PCSK2; MYOD1
Function protein domain specific binding
Related Protein XPO1; CEP68; HOMER2; ARFIP2; TFDP2; BHLHE40; DDC; CALM3; RAB27B; OCLN
Function receptor binding
Related Protein Itga10&Itgb1; WNT7A; ANGPTL1; TRIM24; PLAT; NPFF; ANKRD13C; NRG3; TRDN; INSL4
Function sequence-specific DNA binding
Related Protein POU4F1; CLOCK; PPARD; LMX1B; FOXC1A; NR6A1; TEFB; SIX2B; PAX6A; FOXO3
Function steroid binding
Related Protein PAQR7B; ESRRB; CYP21A2; NR3C2; PAQR8; CYP3A4; SERPINA6; ESRRGB; PDIA2; HSD17B10
Function transcription factor activity, sequence-specific DNA binding
Related Protein TBP; LHX1; SOX2; E4F1; PPARAB; TCF7; TA; FOXP4; RERE; ZNF613
Function transcription factor binding
Related Protein NLRP3; DNAJA3; TCF12; TAF7L; ZBTB49; Ar; HDAC9; NFATC3; BPTF; HDAC8
Function transcription regulatory region DNA binding
Related Protein HNF4A; NCOR1; NR5A2; SP1; HIVEP3; CITED1; SALL4; TFEB; KLF1; HIVEP2
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein PITX3; CREB3; MEOX2; GLI3; CRX; ELK1; EBF1; NKX2; TBX20; Ar
Function zinc ion binding
Related Protein RXRAA; RNF145B; NHLRC1; FHL5; MEX3C; CAD; RORCB; TRAIP; TRAF4A; PAPLNB

AR Related Articles

Wang, YY; Tang, L; et al. Multiplexed gold nanorod array biochip for multi-sample analysis. BIOSENSORS & BIOELECTRONICS 67:18-24(2015).
Tilli, TM; Ferreira, LB; et al. Osteopontin-c mediates the upregulation of androgen responsive genes in LNCaP cells through PI3K/Akt and androgen receptor signaling. ONCOLOGY LETTERS 9:1845-1850(2015).

AR Related Gene Family

TNF Cytokines