| Description : |
This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
149.2 kDa |
| AA Sequence : |
MEDGKPVWAPHPTDGFQMGNIVDIG PDSLTIEPLNQKGKTFLALINQVFP AEEDSKKDVEDNCSLMYLNEATLLH NIKVRYSKDRIYTYVANILIAVNPY FDIPKIYSSEAIKSYQGKSLGTRPP HVFAIADKAFRDMKVLKMSQSIIVS GESGAGKTENTKFVLRYLTESYGTG QDIDDRIVEANPLLEAFGNAKTVRN NNSSRFGKFVEIHFNEKSSVVGGFV SHYLLEKSRICVQGKEERNYHIFYR LCAGASEDIREKLHLSSPDNFRYLN RGCTRYFANKETDKQILQNRKSPEY LKAGSMKDPLLDDHGDFIRMCTAMK KIGLDDEEKLDLFRVVAGVLHLGNI DFEEAGSTSGGCNLKNKSAQSLEYC AELLGLDQDDLRVSLTTRVMLTTAG GTKGTVIKVPLKVEQANNARDALAK TVYSHLFDHVVNRVNQCFPFETSSY FIGVLDIAGFEYFEHNSFEQFCINY CNEKLQQFFNERILKEEQELYQKEG LGVNEVHYVDNQDCIDLIEAKLVGI LDILDEENRLPQPSDQHFTSAVHQK HKDHFRLTIPRKSKLAVHRNIRDDE GFIIRHFAGAVCYETTQFVEKNNDA LHMSLESLICESRDKFIRELFESST NNNKDTKQKAGKLSFISVGNKFKTQ LNLLLDKLRSTGASFIRCIKPNLKM TSHHFEGAQILSQLQCSGMVSVLDL MQGGYPSRASFHELYNMYKKYMPDK LARLDPRLFCKALFKALGLNENDYK FGLTKVFFRPGKFAEFDQIMKSDPD HLAELVKRVNHWLTCSRWKKVQWCS LSVIKLKNKIKYRAEACIKMQKTIR MWLCKRRHKPRIDGLVKVGTLKKRL DKFNEVVSVLKDGKPEMNKQIKNLE ISIDTLMAKIKSTMMTQEQIQKEYD ALVKSSEELLSALQKKKQQEEEAER LRRIQEEMEKERKRREEDEKRRRKE EEERRMKLEMEAKRKQEEEERKKRE DDEKRIQAEVEAQLARQKEEESQQQ AVLEQERRDRELALRIAQSEAELIS DEAQADLALRRNDGTRPKMTPEQMA KEMSEFLSRGPAVLATKAAAGTKKY DLSKWKYAELRDTINTSCDIELLAA CREEFHRRLKVYHAWKSKNKKRNTE TEQRAPKSVTDYDFAPFLNNSPQQN PAAQIPARQREIEMNRQQRFFRIPF IRPADQYKDPQSKKKGWWYAHFDGP WIARQMELHPDKPPILLVAGKDDME MCELNLEETGLTRKRGAEILPRQFE EIWERCGGIQYLQNAIESRQARPTY ATAMLQSLLKTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
