MYO1C
-
Official Full Name
myosin IC -
Overview
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. -
Synonyms
MYO1C;myosin IC;unconventional myosin-Ic;myr2;myosin-Ic;myosin I beta;myosin-I beta;nuclear myosin I;NMI;MMIb;MMI-beta;FLJ23903
Recombinant Proteins
- Mouse
- Chicken
- Rat
- Human
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
MYO1C involved in several pathways and played different roles in them. We selected most pathways MYO1C participated on our site, such as Fcgamma receptor (FCGR) dependent phagocytosis,Immune System,Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | KIF2C,IRF9,DDX41,SEC23A,NLRP4C,HAVCR2,UFL1,UBE2E3,RAPGEF4,KLRF1 |
| Translocation of GLUT4 to the plasma membrane | RALAB,STXBP3,RAB10,RALAA |
| Fcgamma receptor (FCGR) dependent phagocytosis | WIPF2,ACTR2B,ACTR2,PLD4,DOCK1,IgG3,MYO9B,WASF3,ABI1B,WASF2 |
| Innate Immune System | IRAK3,TXNIPB,FCN2,CLEC4D,BTR30,CTSK,WIPF3,TXNIPA,KIR2DS2,PPAPDC1A |
| Regulation of actin dynamics for phagocytic cup formation | ABI1B,WIPF3,ABI1A,NCKIPSD,MYO9B,WIPF2 |
| Insulin Signaling | KIF5B,FLOT1,RRAD,MAPK6,MAP3K9,CAP1,STXBP1A,MINK1,MAPK4,STXBP2 |
| Membrane Trafficking | CLINT1,DTNBP1,MIA3,PREB,GJB3,GJD3,ARCN1B,CTAGE5,PICALM,AP1S3A |
| Vesicle-mediated transport | GAK,SH3D19,BLOC1S4,YIPF6,TCEAL4,PPP6R1,ARCN1,NAPB,TRAPPC5,COPB1 |
Protein Function
MYO1C has several biochemical functions, for example, ATP binding,Ral GTPase binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO1C itself. We selected most functions MYO1C had, and list some proteins which have the same functions with MYO1C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | PICK1,PDZD11,CAV3,PHB2,ECM1,VPS4B,ZBTB16,SCLT1,NCF2,MPDZ |
| Ral GTPase binding | FLNA,PIH1D2,PRKCH,EXOC5,EXOC4,EXOC8,RALBP1,USP33,RAB34,LSM2 |
| actin binding | CLMN,MYBPC2,EPB49,WIPF1,FSCN1A,WASL,SPNA1,MYH9A,MYH1E,CFL1 |
| receptor binding | ABL2,TAC1,HMGCL,FGF24,NOS2,EPHX2,FYNB,ICOSLG,RIPK2,NPFFL |
| motor activity | MYL6,KIF2A,VMHCL,DNAI1,MYO6B,DYNLT1,KIF18B,MYO1EB,MYH1E,MYH11 |
| ATP binding | HSPD1,SRPK1B,PCXA,ULK1,KDRL,PFKFB2,KSR2,ABCB9,HSPH1,TRIOA |
| protein binding | CIB1,SORT1,FDX1L,OTX2,NDC80,SEPT2,PDGFRB,AVPR2,CCNE1,WIPF2 |
| actin-dependent ATPase activity | MYO7A,MYO3A,MYH7,MYH10,MYL6,MYO1D,MYH9 |
| calmodulin binding | MARCKSB,ATPIF1,DCX,CNGA2,MYO6,MIP,KCNN4,EEF2K,AEBP1,C2orf62 |
Interacting Protein
MYO1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO1C here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO1C.
ESR1;ESR2;GIPC1;PTP4A3;CIAO1;EIF4A2;MAP3K3;NEK6;WRAP73;USP20;RIPK3;PHLDA3;IKBKG;POLR1E;PLEKHG3;RIOK3;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
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