MYO9B

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MYO9B

Official Full Name myosin IXB
Background This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms MYO9B; myosin IXB; CELIAC4; myosin-IXb; CELIAC 4; Celiac disease 4; MYO 9B; Myosin 9B; Myosin IX; Myosin9B; MyosinIX; MyosinIXB; MYR 5; MYR5; Unconventional myosin 9b; unconventional myosin-9b; unconventional myosin IXb
    • Species :
    • Chicken
    • Human
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MYO9B-1146H Recombinant Human MYO9B, GST-tagged E.coli GST
    Human MYO9B-5848H Recombinant Human MYO9B Protein, GST-tagged Wheat Germ GST
    Chicken MYO9B-5474C Recombinant Chicken MYO9B Mammalian Cell His

    MYO9B involved in several pathways and played different roles in them. We selected most pathways MYO9B participated on our site, such as Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO9B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fcgamma receptor (FCGR) dependent phagocytosis ABI1B; WIPF3; MYO1C; ACTR2; BAIAP2; PPAPDC1B; WASF3; DOCK1; WIPF2; MYO9B
    Immune System ERAP2; SEC61B; CD300LG; HAVCR2; TNFRSF13C; EDA; CD160; Siglece; DEFA5; KPNA4
    Innate Immune System PELI2; MAP3K8; PCBP2; DEFB103A; IRF2; ALCAMB; CASP4; HERC5; NLRP4; TLR6
    Regulation of RhoA activity ECT2; DEF6; ARHGEF18; ARHGEF10; ARHGEF3; ARHGEF28; ARHGAP9; MYO9B; OBSCN; ARHGEF10L
    Regulation of actin dynamics for phagocytic cup formation ABI1A; NCKIPSD; MYO1C; WIPF2; MYO9B; ABI1B; WIPF3
    Rho GTPase cycle ARHGAP8; STARD13; GDI2; RHOU; ARHGAP19; FAM13B1; OPHN1; ARHGAP23; RHOF; PLEKHG2
    Signal Transduction SDR16C5; IFT122; USP34; OTULIN; CCDC88C; RSPO2; ARHGAP23; SKIB; PYGO2; DTX2
    Signaling by Rho GTPases RTKN; ABI1A; IQGAP3; NCKIPSD; ARHGAP36; ARHGAP6; FMNL1; ARHGAP29; PRC1B; ARHGEF16

    MYO9B has several biochemical functions, for example, ADP binding, ATP binding, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO9B itself. We selected most functions MYO9B had, and list some proteins which have the same functions with MYO9B. You can find most of the proteins on our site.

    Function Related Protein
    ADP binding LONP1; MYO6; VCP; MYO7A; ME1; PRKAG2; PRKAG1; APAF1; P2RY1; ERN1
    ATP binding RTCD1; NEK10; WRNIP1; NUAK2; CLCN4; DDX52; TARSL2; CDK7; CDK10; MCM3L
    ATPase activity ABCB4; ATAD2B; KIF22; KIF15; ABCG4B; DQX1; DNAH11; ABCF2; OLA1; MYO19
    GTPase activator activity PGAM5; OCRL; ARHGAP6; ARAP3; ARHGAP28; GMIP; RASA3; FAM13B1; CDC42EP4; ARHGAP36
    actin binding EZRA; CAPGA; MYO10; MYO1G; TLN2A; FLII; ADD3; GSNB; TAGLN; PHACTR3A
    calmodulin binding PHKG1A; MAP6; NOS3; ITPKA; GAP43; ITPKB; MARCKSB; CNN3; EDF1; CAMK2B1
    metal ion binding KLF16; COL18A1; ZNF800; HBB-B2; NINL; CYP2AA2; CHORDC1; ZBTB44; PAPL; LIAS
    microfilament motor activity MYH13; MYH8; MYO1E; MYO7A; MYO9B; MYH9; MYH10; MYO3A; MYH3; MYO3B
    protein binding GTSE1; FAM125A; CD8A; ADAMTS5; ID3; MYLIPA; PSENEN; TCEA1; SPG11; ARHGEF2
    NOT protein homodimerization activity MSH6; DDIT3; MSH3; EXT2; MYO9B; KCNA3; MECOM; MLXIPL; NUDT16L1

    MYO9B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO9B here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO9B.

    LRRC41; PKN2; tuf; MOB4; MYC

    Wolters, VM; Alizadeh, BZ; et al. Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. HUMAN IMMUNOLOGY 71:392-396(2010).
    Casella, G; D'Inca, R; et al. Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study. DIGESTIVE AND LIVER DISEASE 42:175-178(2010).

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