MYO9B

  • Official Full Name

    myosin IXB
  • Overview

    This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    MYO9B;myosin IXB;CELIAC4;myosin-IXb;CELIAC 4;Celiac disease 4;MYO 9B;Myosin 9B;Myosin IX;Myosin9B;MyosinIX;MyosinIXB;MYR 5;MYR5;Unconventional myosin 9b;unconventional myosin-9b;unconventional myosin IXb
Cat.# Product name Source (Host) Species Tag Protein Length Price
MYO9B-1146H Recombinant Human MYO9B, GST-tagged E.coli Human GST 1660-1983aa
MYO9B-2790H Recombinant Human MYO9B protein, His-tagged E.coli Human His 1660-1983 aa
MYO9B-5474C Recombinant Chicken MYO9B Mammalian Cells Chicken His
MYO9B-5848H Recombinant Human MYO9B Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    MYO9B involved in several pathways and played different roles in them. We selected most pathways MYO9B participated on our site, such as Fcgamma receptor (FCGR) dependent phagocytosis,Immune System,Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO9B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System TRIM50,CLEC4D,KPNA4,SEC24A,MKRN1,MB21D1,LILRB4,CASP2,KIF2C,CTSH
    Rho GTPase cycle ARHGAP6,DCLRE1B,ARHGEF18A,RHOUA,ARHGAP36,OPHN1,RHOF,ARHGAP19,ARHGAP10,ARHGAP12
    Signaling by Rho GTPases RHOT1A,TAGAPB,ARHGAP12B,MKL1B,ARHGAP6,FAM13B,RHPN2,FGD4,STARD13,RHPN1
    Signal Transduction FGD2,NOTUM1A,MDKB,RGS18,CGNB,GPR37B,FFAR3,NMB,SKI,HECW1B
    Fcgamma receptor (FCGR) dependent phagocytosis WIPF3,WASF3,NCKAP1,IgG3,BAIAP2,ACTR2,NCKIPSD,PPAPDC1B,PPAPDC1A,ABI1
    Regulation of RhoA activity AKAP13,ARHGEF28,ARHGAP4,ARHGAP9,ECT2,ARAP1,ABR,ARHGEF18,FARP1,PLEKHG6
    Innate Immune System RIPK3,PELI1,TAX1BP1,Txn1,BTR22,BTR06,WASF3,CTSLL,NLRP4C,CFHL2
    Regulation of actin dynamics for phagocytic cup formation NCKIPSD,ABI1B,ABI1A,WIPF2,MYO1C,WIPF3

    Protein Function

    MYO9B has several biochemical functions, for example, ADP binding,ATP binding,ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO9B itself. We selected most functions MYO9B had, and list some proteins which have the same functions with MYO9B. You can find most of the proteins on our site.

    Function Related Protein
    ATPase activity ATF7IP,ABCG4B,MACF1,ABCA1B,CENPE,ABCF2,MYH7,ABCA4A,RALBP1,MYH9
    protein binding NSMAF,KIF20A,CSN3,RNF40,CLSTN2,HEPACAM2,GNMT,TARDBP,ZBTB6,PRR13
    metal ion binding ENTPD8,RNF169,ZBTB7A,TRIM2A,ZFP39,LHX2A,CRYABA,CYP2P9,MOXD1L,SOBPB
    ADP binding MYO3A,CHORDC1,CYB5R3,PRPS1,ATP1A1,MYH10,PRKAG2,P2RY1,ADCK3,MYH9
    ATP binding LRRK1,DYNC1H1,GMPS,XRCC6,AKT1,TRIOA,TARSL2,MAP2K5,CCT4,TPK1
    actin binding NRAP,SYN1,FGD4,EVLB,CAPZA1A,MYO19,S100A4,PACRG,INO80,HOMER2
    GTPase activator activity FAM13A,TBC1D2,ARHGAP42A,ARHGEF1,RGS5B,FAM13B1,STXBP5L,CHN2,USP6NL,ARHGAP4A
    calmodulin binding CAMK1GB,CAMK2D,GEM,GAP43,CAMKV,KCNN1,CAMK1,EEF2K,MAP6D1,PLCB3
    NOT protein homodimerization activity KCNA3,MSH3,NUDT16L1,DDIT3,MLXIPL,EXT2,MECOM,MSH6

    Interacting Protein

    MYO9B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO9B here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO9B.

    LRRC41;PKN2;tuf;MOB4;MYC

    Resources

    References

    • Wolters, VM; Alizadeh, BZ; et al. Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. HUMAN IMMUNOLOGY 71:392-396(2010).
    • Casella, G; D'Inca, R; et al. Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study. DIGESTIVE AND LIVER DISEASE 42:175-178(2010).

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