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MYO9B

Official Full Name

myosin IXB
Overview

This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

MYO9B; myosin IXB; CELIAC4; myosin-IXb; CELIAC 4; Celiac disease 4; MYO 9B; Myosin 9B; Myosin IX; Myosin9B; MyosinIX; MyosinIXB; MYR 5; MYR5; Unconventional myosin 9b; unconventional myosin-9b; unconventional myosin IXb;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MYO9B-1146H	Recombinant Human MYO9B, GST-tagged	E.coli	GST	1660-1983aa	$319 / 25ug
Human	MYO9B-5848H	Recombinant Human MYO9B Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MYO9B-2790H	Recombinant Human MYO9B protein, His-tagged	E.coli	His	1660-1983 aa	$319 / 25ug
Chicken	MYO9B-5474C	Recombinant Chicken MYO9B	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MYO9B Related Articles

MYO9B involved in several pathways and played different roles in them. We selected most pathways MYO9B participated on our site, such as Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO9B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Fcgamma receptor (FCGR) dependent phagocytosis	ABI1B;ABI2;WIPF2;ABI1;PPAPDC1A;ACTR2B;DOCK1;PPAPDC1B;MYO1C
Immune System	GRAP2A;TLR10;TRAF7;PJA1;FBXO3;CRP;TRIM68;TRIM10;DUSP3
Innate Immune System	DEFA5;MYO1C;PANX1;IRAK3;NLRP4B;DEFB4B;BFB;MGC174155;DDX41
Regulation of RhoA activity	DLC1;ARHGEF10L;FARP1;ARHGEF10;ABR;ARHGEF3;ARHGEF25;AKAP13;ARHGEF28
Regulation of actin dynamics for phagocytic cup formation	NCKIPSD;WIPF3;MYO1C;MYO9B;ABI1A;WIPF2;ABI1B
Rho GTPase cycle	RHOV;RHOT1;DEPDC7;ARHGEF3;ARHGAP23;ARHGAP12B;NET1;ARHGEF1A;RHOU
Signal Transduction	PLEKHG2;SHRPRBCK1R;RBCK1;RNF43;PENKB;ARHGAP12B;APLN;CRHR2;HECW1B
Signaling by Rho GTPases	ARHGAP31;ARHGAP18;ARHGAP29B;ARHGAP29;ARHGAP6;ARHGAP17;FAM13B;CHN2;MKL1B

MYO9B has several biochemical functions, for example, ADP binding, ATP binding, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO9B itself. We selected most functions MYO9B had, and list some proteins which have the same functions with MYO9B. You can find most of the proteins on our site.

Function	Related Protein
ADP binding	PRPS2;CYB5R3;ME1;GCLC;MYO9B;ERN1;GLUD2;TAP1;P2RY1
ATP binding	UBE2G1B;SMYHC1;ATP6AP1;NETO2;ROCK2A;RECQL;CDK3;MYH13;PAPOLB
ATPase activity	KIF14;DYNC2H1;ABCB4;HSPA8;ABCA13;ABCC8;DNAH5;TOR1A;HSP90AA1
GTPase activator activity	RABGAP1;ARHGAP12;IQGAP3;ARHGAP10;RALBP1;RASAL3;THY1;SOS1;TBC1D10A
actin binding	HCLS1;MYO7B;DBNL;TRPV4;WHAMM;FSCN2A;TPM2;ARPC1A;SNTB2
calmodulin binding	PLCB1;ORAI1;RIT2;NRGNA;MYH11;CAMK1GA;PATE4;SLC9A1;KCNQ1
metal ion binding	ZNF669;ZNF157;KLF8;IHHB;JMJD1C;PPM1LA;GTPBP6;TDO2A;DDHD1B
microfilament motor activity	MYO7A;MYH10;MYO5B;MYH9;MYO5A;MYO3B;MYH3;STRC;MYO3A
protein binding	DDIT4L;BCL2L10;LRSAM1;RTN3;ILK;PCBP2;PSAP;FBXL15;MYPOP
NOT protein homodimerization activity	MSH6;EXT2;NUDT16L1;MSH3;MECOM;MLXIPL;MYO9B;KCNA3;DDIT3

MYO9B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO9B here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO9B.

LRRC41; PKN2; tuf; MOB4; MYC

Wolters, VM; Alizadeh, BZ; et al. Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. HUMAN IMMUNOLOGY 71:392-396(2010).

Casella, G; D'Inca, R; et al. Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study. DIGESTIVE AND LIVER DISEASE 42:175-178(2010).