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Official Full Name myosin VI
Background This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss.
Synonyms MYO6; myosin VI; deafness, autosomal recessive 37 , DFNA22, DFNB37; myosin-VI; KIAA0389; Deafness autosomal recessive 37; DFNA 22; DFNA22; DFNB 37; DFNB37; MYO 6; MYO6_HUMAN; Myosin 6; Myosin6; MyosinVI; Unconventional myosin-6
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MYO6-4006HCL Recombinant Human MYO6 293 Cell Lysate HEK293 N/A
    Human MYO6-4814H Recombinant Human MYO6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MYO6-502H Recombinant Human MYO6 Mammalian Cell His
    Human MYO6-5843H Recombinant Human MYO6 Protein, GST-tagged Wheat Germ GST
    Mouse Myo6-4260M Recombinant Mouse Myo6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque MYO6-2927R Recombinant Rhesus monkey MYO6 Protein, His-tagged Mammalian Cell His
    Chicken MYO6-6300C Recombinant Chicken MYO6 Mammalian Cell His

    myo6 involved in several pathways and played different roles in them. We selected most pathways myo6 participated on our site, such as Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with myo6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gap junction degradation MYO6B; MYO6A; MYO6; DAB2
    Gap junction trafficking CX27.5; GJC1; DAB2; GJD3; GJA8; MYO6A; MYO6B; GJA4; GJB2; CX30.3
    Gap junction trafficking and regulation GJB4; DAB2; GJA5; CX27.5; GJC1; CX30.3; GJA8; GJA4; GJB2; MYO6B
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity NSFB; CACNG3; CACNG2; MYO6; PICK1; HAND2; AKAP5; NSFA; GRIP1
    Membrane Trafficking SH3D19; MYO6B; NSFB; PPP6R3; PICALMA; TRAPPC6BL; EXOC1; CLVS1; RALAB; STAM2
    Neuronal System KCNMA1; KCNH1A; KCNJ1A.4; SYN2; KCNAB2; KCNC3A; SLC1A2A; DLG3; KCNK13A; KCNK7
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell CHRNA5; DLG1L; NSFA; GRIP1; NCALDA; CAMKK1B; NSFB; CHRND; CHRNE; GABRR2A
    Stabilization and expansion of the E-cadherin adherens junction LIMA1; LPP; PLEKHA7; MYO6; KIFC3

    myo6 has several biochemical functions, for example, ADP binding, ATP binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by myo6 itself. We selected most functions myo6 had, and list some proteins which have the same functions with myo6. You can find most of the proteins on our site.

    Function Related Protein
    ADP binding PRKAG2; ATP1A1; MYH10; ME1; ABCG1; CHORDC1; P2RY1; APAF1; MYO6; PKM
    ATP binding RAD50; SLC22A5; DCAKD; GAK; IARS2; EIF2AK1; PI4K2A; MAP3K1; FAM20B; MAP4K6
    actin binding ANTXR2A; MYO7A; MKL1; FSCN2; IPP; PARVG; TWF2B; YWHAH; FMN1; DIAP3
    actin filament binding SPTA1; TRIOBP; PKNOX2; ACTN1; PICK1; CORO1A; TLN1; ACTN2; CORO2A; WIPF2
    calmodulin binding PATE4; TJP1; RASGRF2; TRPV1; VAMP2; SPHK1; SLC8A1; TRPV5; KCNH1; NETO2
    minus-end directed microfilament motor activity MYO6
    motor activity MYO1EB; MYH4; MYH1E; MYHZ2; DCTN1; KIF18B; SMYHC2; KLC1; DCTN2; DNAHC8
    protein binding KRTAP9-2; TBC1D10C; REST; MBP; C16orf87; PRAP1; RPP25; PUM1; TRMT2B; GRAP2

    myo6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with myo6 here. Most of them are supplied by our site. Hope this information will be useful for your research of myo6.


    Zak, M; Bress, A; et al. Ergic2, a Brain Specific Interacting Partner of Otoferlin. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 29:941-948(2012).

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