Active Recombinant Mouse Ctla4 Protein, hIgG/His-tagged
Cat.No. : | Ctla4-06M |
Product Overview : | Recombinant mouse Ctla-4 (38-161aa), fused to hIgG-His-tag at C terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
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Description : | This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Source : | Insect cell |
Species : | Mouse |
Tag : | hIgG/His |
Form : | Liquid |
Bio-activity : | The activity is determined by the IL-2 ELISA in a using stimulated Jurkat human acute T cell leukemia cells with Human B7-1/CD80. The ED50 range ≤ 150 ng/mL. |
Molecular Mass : | 40.6 kDa (363aa) |
AA Sequence : | IQVTQPSVVLASSHGVASFPCEYSP SHNTDEVRVTVLRQTNDQMTEVCAT TFTEKNTVGFLDYPFCSGTFNESRV NLTIQGLRAVDTGLYLCKVELMYPP PYFVGMGNGTQIYVIDPEPCPDSD |
Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
Purity : | > 90% by SDS-PAGE |
Applications : | SDS-PAGE, Bioactivity |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5 mg/mL (determined by Absorbance at 280nm) |
Storage Buffer : | Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
Gene Name : | Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Mus musculus (house mouse) ] |
Official Symbol : | Ctla4 |
Synonyms : | Ctla4; cytotoxic T-lymphocyte-associated protein 4; Cd152; Ly-56; Ctla-4; cytotoxic T-lymphocyte protein 4; CD152 antigen; cytotoxic T-lymphocyte-associated antigen 4 |
Gene ID : | 12477 |
mRNA Refseq : | NM_009843 |
Protein Refseq : | NP_033973 |
UniProt ID : | P09793 |
Products Types
◆ Recombinant Protein | ||
CTLA4-647C | Recombinant Cynomolgus monkey CTLA4 Protein | +Inquiry |
CTLA4-2075H | Recombinant Human CTLA4 Protein, GST-tagged | +Inquiry |
CTLA4-024H | Recombinant Human CTLA4 Protein, C-His-tagged | +Inquiry |
CTLA4-657R | Recombinant Rat CTLA4 Protein, Fc-tagged | +Inquiry |
Ctla4-158M | Recombinant Mouse Ctla4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CTLA4-2526HCL | Recombinant Human CTLA4 cell lysate | +Inquiry |
CTLA4-2179MCL | Recombinant Mouse CTLA4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1712 | CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
Kit-1713 | CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.
CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.
Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.
CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.
While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.
Customer Reviews (3)
Write a reviewIt has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.
The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.
the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.
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