Recombinant Human CTLA4 Protein, C-His-tagged
Cat.No. : | CTLA4-024H |
Product Overview : | Recombinant Human CTLA4 Protein with C-His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Cytotoxic T-lymphocyte protein 4 (CTLA-4, CD152) is an Ig superfamily member that negatively regulates early T cell activation. The CTLA-4 protein is primarily expressed on T cells, including CD8+ cytotoxic T cells, CD4+ helper T cells, and CD4+/FoxP3+ regulatory T cells. CTLA-4 protein competes with CD28 for B7.1 (CD80) and B7.2 (CD86) binding at the cell surface, which results in the down regulation of T cell activity. The activation of SHP-2 and PP2A downstream of CTLA-4 attenuates TCR signaling. Research studies indicate that CTLA4 knockout mice display lymphoproliferative disorders leading to early death, confirming the role of CTLA-4 as a negative regulator of T cells. Mutations in the corresponding CTLA4 gene are associated with multiple disorders, including insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, and type V autoimmune lymphoproliferative syndrome. Additional studies demonstrate that CTLA-4 blockade is an effective strategy for tumor immunotherapy. |
Source : | E. coli |
Species : | Human |
Tag : | C-His |
Molecular Mass : | ~14 kDa |
AA Sequence : | KAMHVAQPAVVLASSRGIASFVCEY ASPGKATEVRVTVLRQADSQVTEVC AATYMMGNELTFLDDSICTGTSSGN QVNLTIQGLRAMDTGLYICKVELMY PPPYYLGIGNGTQIYVIDPEPCPDS D |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Concentration : | ≥0.5 mg/mL |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens (human) ] |
Official Symbol : | CTLA4 |
Synonyms : | CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3 , CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; GRD4; CTLA-4; IDDM12; CELIAC3; |
Gene ID : | 1493 |
mRNA Refseq : | NM_001037631 |
Protein Refseq : | NP_001032720 |
MIM : | 123890 |
UniProt ID : | P16410 |
Products Types
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CTLA4-2073P | Recombinant CTLA4 Protein, His-Flag-StrepII-tagged | +Inquiry |
Ctla4-652H | Recombinant Human Ctla4 Protein, Strep-tagged | +Inquiry |
CTLA4-1106H | Recombinant Human CTLA4 Protein (Met1-Phe162), HlgG1 Fc-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
CTLA4-1047CCL | Recombinant Cynomolgus CTLA4 cell lysate | +Inquiry |
CTLA4-2526HCL | Recombinant Human CTLA4 cell lysate | +Inquiry |
CTLA4-2179MCL | Recombinant Mouse CTLA4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1713 | CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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