"RUNX3" Related Products

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Recombinant Human RUNX3, His-tagged

Cat.No.: RUNX3-31339TH
Product Overview: Recombinant fragment, corresponding to amino acids 53-186 of Human RUNX3 with N terminal His tag; 155 amino acids with tag, MWt 17.1kDa.
Description: This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5-PYGPYGGT-3 found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein length: 134 amino acids
Conjugation: HIS
Molecular Weight: 17.100kDa inclusive of tags
Source: E. coli
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MRSMVDVLAD HAGELVRTDS PNFLCSVLPS HWRCNKTLPV AFKVVALGDV PDGTVVTVMA GNDENYSAEL RNASAVMKNQ VARFNDLRFV GRSGRGKSFT LTITVFTNPT QVATYHRAIK VTVDGPREPR RHRQK
Sequence Similarities: Contains 1 Runt domain.
Gene Name: RUNX3 runt-related transcription factor 3 [ Homo sapiens ]
Official Symbol: RUNX3
Synonyms: RUNX3; runt-related transcription factor 3; CBFA3; AML2; PEBP2A3;
Gene ID: 864
mRNA Refseq: NM_001031680
Protein Refseq: NP_001026850
MIM: 600210
Uniprot ID: Q13761
Chromosome Location: 1p36
Pathway: Endochondral Ossification, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem;
Function: ATP binding; DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; protein binding; sequence-specific DNA binding RNA polymerase II transcription factor activity;

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