RUNX2

Official Full Name

runt-related transcription factor 2
Overview

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt;DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as;a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA;both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been;associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different;protein isoforms result from the use of alternate promoters as well as alternate splicing.
Synonyms

RUNX2; runt-related transcription factor 2; CBFA1, CCD, CCD1; AML3; PEBP2A1; PEBP2aA1; CBF-alpha-1; PEA2-alpha A; PEBP2-alpha A; oncogene AML-3; acute myeloid leukemia 3 protein; SL3-3 enhancer factor 1 alpha A subunit; osteoblast-specific transcription f;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RUNX2-28321TH	Recombinant Human RUNX2	Wheat Germ	Non	140 amino acids	Inquiry
Human	RUNX2-30473TH	Recombinant Human RUNX2	Wheat Germ	Non	100 amino acids	Inquiry
Human	RUNX2-48H	Recombinant Human RUNX2 protein, His-tagged	E.coli	His		Inquiry
Human	RUNX2-2108HCL	Recombinant Human RUNX2 293 Cell Lysate	HEK293	Non		Inquiry
Human	RUNX2-2107HCL	Recombinant Human RUNX2 293 Cell Lysate	HEK293	Non		Inquiry
Human	RUNX2-6645H	Recombinant Human RUNX2 Protein (Val219-Val404), N-His tagged	E.coli	His	Val219-Val404	Inquiry
Human	RUNX2-1163HFL	Recombinant Full Length Human RUNX2 Protein, C-His-tagged	E.coli	His		Inquiry
Human	RUNX2-6644H	Recombinant Human RUNX2 Protein	E.coli	Non		Inquiry
Mouse	Runx2-5723M	Recombinant Mouse Runx2 protein, His-tagged	E.coli	His	Ser125~Ala352	Inquiry
Chicken	RUNX2-5704C	Recombinant Chicken RUNX2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
RUNX2 Related Signal Pathway

RUNX2 involved in several pathways and played different roles in them. We selected most pathways RUNX2 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RUNX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Transcriptional misregulation in cancer	FEV;TAF15;HIST1H3D;SS18;EWSR1;TRAF1;NTRK1;BCL2A1;GOLPH3

RUNX2 has several biochemical functions, for example, ATP binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RUNX2 itself. We selected most functions RUNX2 had, and list some proteins which have the same functions with RUNX2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	PKMYT1;NTRK2;FARSA;CHKB;LYN;PDK2;MYO9B;DDX49;ATP2A2
RNA polymerase II core promoter proximal region sequence-specific DNA binding	PPARA;PITX1;KCNA3;ETS2;SMAD3;E2F4;NKX6-1;MTF1;MESP1
RNA polymerase II core promoter sequence-specific DNA binding	TFAP2A;STAT5A;SPI1;HNF4A;SP1;TRP53;WBP2;H2AFY;STAT6
RNA polymerase II transcription factor activity, sequence-specific DNA binding	NPAS4;NPAS1;EPAS1B;KLF11;ZNF18;LYL1;SP3A;ZNF488;FOXD5
bHLH transcription factor binding	TCF4;ASCL1;USF1;MAP3K10;TCF3B;IKZF4;TCF3;HAND1;LMO2
chromatin binding	PRDM13;KDM8;RCC1;NUP62;MSL1A;SAFB;ELK1;IFT74;GATA2B
histone deacetylase binding	NCOR1;MEF2A;PARK2;PKN1;USF1;KLF4;GCM1;HDAC5;GLI3
protein binding	KIF4A;DAPK3;TP73;RBM8A;NLK;FBXO34;ZNF263;MAGEB2;HDAC5
protein domain specific binding	YWHAE2;EZR;RARA;VCP;YWHAB;NLRP1;ARRB2;POU2F2;CA
repressing transcription factor binding	HDAC9;PRDM5;GMNN;HDAC1;PARK7;HDAC7A;TLE4;ARNTL;MYC
transcription factor activity, sequence-specific DNA binding	MYCLB;FOXF2A;ELF1;RARAB;ZFP629;ZSCAN2;NOTCH1;ZFP146;L3MBTL4
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	YBX1;PGR;FOXC2;KLF13;HNF1A;NR4A1;GABPA;POU1F1;SIX4

RUNX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RUNX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RUNX2.

PIN1; TP73; SMAD6; SMAD5; SMURF1; MYC

Research Area

Li, YJ; El Mozen, LA; et al. Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. SCIENTIFIC REPORTS 5:-(2015).

Xu, LL; Liu, Y; et al. U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. CELL AND TISSUE RESEARCH 359:537-545(2015).