RUNX3

Official Full Name

runt-related transcription factor 3
Overview

This protein is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer.
Synonyms

RUNX3; runt-related transcription factor 3; CBFA3; AML2; PEBP2A3; CBF-alpha-3; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2-alpha C; oncogene AML-2; transcription factor AML2; acute myeloid leukemia gene 2; acute myeloid leukemia 2 protein; core-binding factor subunit alpha-3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; core-binding factor, runt domain, alpha subunit 3; polyomavirus enhancer-binding protein 2 alpha C subunit; PEBP2aC; FLJ34510; MGC16070;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Yeast

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RUNX3-2500H	Active Recombinant Human Runt-related Transcription Factor 3, His-tagged	Yeast	His		Inquiry
Human	RUNX3-31339TH	Recombinant Human RUNX3, His-tagged	E.coli	His	134 amino acids	Inquiry
Human	RUNX3-2106HCL	Recombinant Human RUNX3 293 Cell Lysate	HEK293	Non		Inquiry
Human	RUNX3-3456H	Recombinant Human RUNX3 protein, His&Myc-tagged	E.coli	His&Myc	1-415aa	Inquiry
Mouse	Runx3-8208M	Recombinant Mouse Runx3 protein, His & T7-tagged	E.coli	His&T7	Met1~Asp250	Inquiry
Zebrafish	RUNX3-9144Z	Recombinant Zebrafish RUNX3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
RUNX3 Related Signal Pathway

RUNX3 involved in several pathways and played different roles in them. We selected most pathways RUNX3 participated on our site, such as Endochondral Ossification, SIDS Susceptibility Pathways, TGF Beta Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RUNX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endochondral Ossification	MMP13;DDR2;ADAMTS5;ADAMTS4;NKX3.2;SOX5;IFT88;COL10A1;RUNX3
SIDS Susceptibility Pathways	EN1;CTCF;KCNQ1;DEAF1;LMX1B;TSPYL1;PHOX2A;IL1RN;POU2F2
TGF Beta Signaling Pathway	ZFP423;NOG;ZNF423;TGFBR3;LEFTY1;ENG;FST;FOXH1;RUNX3

RUNX3 has several biochemical functions, for example, ATP binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RUNX3 itself. We selected most functions RUNX3 had, and list some proteins which have the same functions with RUNX3. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ATP2B1B;FGFR3;RAD51L3;MAP4K5;HSPA7;PDPK1A;NLRP2;UBE2F;ABCF1
RNA polymerase II regulatory region sequence-specific DNA binding	ZNF711;BCL6;NR1D1;IRF2;ZIK1;FOXK1;ARID3A;ZFP39;GATA1A
RNA polymerase II transcription factor activity, sequence-specific DNA binding	FOXD1L;FOXN1;FLI1;PHB;TFAP2E;FLI1B;SOX14;FOXO3A;NPAS1
protein binding	SNRPF;ZNF559-ZNF177;LOC149950;RAB7A;WBP4;ANXA5;KRT5;HSF1;PPP2R1B
transcription factor activity, sequence-specific DNA binding	STAT1A;RARGA;YBX1;POU2F1A;SS18L1;DDIT3;HOXB3A;RCAN1;GRHL2

RUNX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RUNX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RUNX3.

CTNNB1; TCF7L2

Research Area

Epithelial Stem Cell Transcription Factors

Cancer Stem Cell Transcription Factors

Takizawa, F; Araki, K; et al. Transcription analysis of two Eomesodermin genes in lymphocyte subsets of two teleost species. FISH & SHELLFISH IMMUNOLOGY 36:215-222(2014).

Garrity-Park, M; Loftus, EV; et al. Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: Association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation. INFLAMMATORY BOWEL DISEASES 18:275-283(2012).