Recombinant Human FUT8 Protein, MYC/DDK-tagged

• Cat.No.: FUT8-2659H
• Product Overview: Recombinant Human FUT8 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Description: This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 66.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) [ Homo sapiens ]
• Official Symbol: FUT8
• Synonyms: MGC26465
• Gene ID: 2530
• mRNA Refseq: NM_004480
• Protein Refseq: NP_004471
• MIM: 602589
• UniProt ID: Q9BYC5

Reviews

04/01/2021

With the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.

06/30/2020

Researchers who have utilized the FUT8 protein laud its reliability and effectiveness in their studies.

05/12/2017

Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.

Q&As

Can manipulating FUT8 protein have implications in cancer therapy?

Yes, altering FUT8 activity can impact cancer cell growth and metastasis, making it a potential target for cancer therapies.

Are there any challenges in targeting FUT8 protein for therapeutic interventions?

One challenge is the specificity of FUT8 inhibitors, ensuring they do not affect other essential glycosylation processes in the body.

Can FUT8 protein modifications be used as biomarkers for certain diseases?

Yes, abnormal glycosylation patterns due to FUT8 alterations can serve as biomarkers for diseases like cancer, aiding in early diagnosis.

How does FUT8 protein impact the development of therapeutic antibodies?

FUT8-mediated glycosylation of antibodies can enhance their stability and effector functions, making them more effective in treating diseases like cancer and autoimmune disorders.

Are there any diseases directly linked to FUT8 protein deficiency?

Yes, deficiencies in FUT8 have been associated with certain types of cancers and developmental disorders.