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FUT3

  • Official Full Name

    fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)

  • Overview

    The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
  • Synonyms

    FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); fucosyltransferase 3 (galactoside 3(4) L fucosyltransferase, Lewis blood group included) , LE; galactoside 3(4)-L-fucosyltransferase; CD174; MGC131739; alpha (1,3/1,4) fucosyltransferase; Blood group Lewis alpha-4-fucosyltransferase; FT3B; Fucosyltransferase 3; Fucosyltransferase III; FucT-III; FUT3_HUMAN; galactoside 3(4) L fucosyltransferase, Lewis blood group; LE; Les; Lewis B Blood Group antigen; Lewis FT; alpha-(1,3/1,4)-fucosyltransferase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FUT3-573H Active Recombinant Human Fucosyltransferase 3 (galactoside 3 (4)-L-fucosyltransferase, Lewis blood group), His-tagged Mammalian cells His
Human FUT3-2322H Recombinant Human FUT3, His-tagged E.coli His 350aa
Human FUT3-5652H Recombinant Human FUT3 protein, His & T7-tagged E.coli His/T7 Phe30~Lys259 (Accession # P21217)
Human FUT3-6114HCL Recombinant Human FUT3 293 Cell Lysate HEK293 N/A
Human FUT3-5181HF Recombinant Full Length Human FUT3 Protein, GST-tagged In Vitro Cell Free System GST 361 amino acids
Human FUT3-4561H Recombinant Human FUT3 Protein, GST-tagged Wheat Germ GST
Human FUT3-2987H Recombinant Human FUT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FUT3-042H Recombinant Human FUT3 Protein, His-tagged E.coli His
Human FUT3-4165H Recombinant Human FUT3 Protein (Arg35-Thr361), C-His tagged Mammalian cells C-His Arg35-Thr361
Human FUT3-2987H-B Recombinant Human FUT3 Protein Pre-coupled Magnetic Beads HEK293
Human FUT3-129H Recombinant Human FUT3 Protein (35-361), N-His tagged E.coli N-His 35-361
Homo sapiens (Human) RFL21483HF Recombinant Full Length Human Galactoside 3(4)-L-Fucosyltransferase(Fut3) Protein, His-Tagged E.coli expression system His Full Length (1-361)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FUT3 Related Articles
  • FUT3 Related Research Area

FUT3 involved in several pathways and played different roles in them. We selected most pathways FUT3 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosphingolipid biosynthesis - lacto and neolacto seriesGGTA1;B3GNT2;FUT1;FUT3;ST3GAL3;B3GNT5;B3GNT1;B4GALT2;B3GNTL2
Metabolic pathwaysPIP5K1B;CYP27B1;GGT5;CPOX;AGMAT;HSD3B5;DNMT3;UPB1;CYP2C54

FUT3 has several biochemical functions, for example, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity, alpha-(1->3)-fucosyltransferase activity, fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT3 itself. We selected most functions FUT3 had, and list some proteins which have the same functions with FUT3. You can find most of the proteins on our site.

Function Related Protein
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activityFUT6;FUT3
alpha-(1->3)-fucosyltransferase activityFUT6;B3GNT9-PS;B3GNTL1;GLT8D1;GTDC2;GALNT18A;FUT10;DPY19L4;4931440L10Rik
fucosyltransferase activityDPY19L1;B3GNTL1;PIGB;FUT9;FUT9D;FUT9A;FUT6;GALNT18A;FUT1

FUT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUT3.

Brazil, JC; Liu, RP; et al. alpha 3/4 Fucosyltransferase 3-Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration. JOURNAL OF IMMUNOLOGY 191:4804-4817(2013).
Silsirivanit, A; Araki, N; et al. CA-S27: A novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma. CANCER SCIENCE 104:1278-1284(2013).
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