"TGFB1" Related Products

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Recombinant Human TGFB1, Fc-tagged

Cat.No.: TGFB1-509H
Product Overview: The extracellular domain of a mutant human TGFβ1 is fused to the N-terminus of the Fc region of human IgG4. Site-directed mutagenesis was used to change three cysteine codons into a serine codon that are located in the pro region of the TGF-β precursor at
Description: TGF-beta1 (Transforming growth factor beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-beta1 is encoded by the TGFB1 gene. TGF-beta1 was first identified in human platelets as a protein with a molecular mass of 25 kaD with a potential role in wound healing. It was later characterized as a large protein precursor (containing 390 aa) that was proteolytically processed to produce a mature peptide of 112 aa. TGF-beta1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGF-beta1.
Source: CHO Cells
Species: Human
Tag: Fc
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Shows the biological function of the TGFβ1 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
Purity: ≥98% (SDS-PAGE)
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.
Gene Name: TGFB1 transforming growth factor, beta 1 [ Homo sapiens ]
Official Symbol: TGFB1
Synonyms: TGFB1; transforming growth factor, beta 1; DPD1, TGFB; transforming growth factor beta-1; Camurati Engelmann disease; CED; TGFbeta; TGF-beta-1; TGF-beta 1 protein; latency-associated peptide; LAP; DPD1; TGFB;
Gene ID: 7040
mRNA Refseq: NM_000660
Protein Refseq: NP_000651
MIM: 190180
UniProt ID: P01137
Chromosome Location: 19q13.1
Pathway: ACE Inhibitor Pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem;
Function: enzyme binding; eukaryotic cell surface binding; growth factor activity; protein N-terminus binding; protein binding; protein heterodimerization activity; protein homodimerization activity; type II transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding;

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