Recombinant Human HSPA9, His-tagged

• Cat.No.: HSPA9-29142TH
• Product Overview: Recombinant full length human Grp75 protein, fused to His tag at N terminus; 654 amino acids, 71 kDa.

Specification

• Description: This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl buffer, 0.5mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MASEAIKGAV VGIDLGTTNS CVAVMEGKQA KVLENAEGAR TTPSVVAFTA DGERLVGMPA KRQAVTNPNN TFYATKRLIG RRYDDPEVQK DIKNVPFKIV RASNGDAWVE AHGKLYSPSQ IGAFVLMKMK ETAENYLGHT AKNAVITVPA YFNDSQRQAT KDAGQISGLN VLRVINEPTA AALAYGLDKS EDKVIAVYDL GGGTFDISIL EIQKGVFEVK STNGDTFLGG EDFDQALLRH IVKEFKRETG VDLTKDNMAL QRVREAAEKA KCELSSSVQT DINLPYLTMD SSGPKHLNMK LTRAQFEGIV TDLIRRTIAP CQKAMQDAEV SKSDIGEVIL VGGMTRMPKV QQTVQDLFGR APSKAVNPDE AVAIGAAIQG GVLAGDVTDV LLLDVTPLSL GIETLGGVFT KLINRNTTIP TKKSQVFSTA ADGQTQVEIK VCQGEREMAG DNKLLGQFTL IGIPPAPRGV PQIEVTFDID ANGIVHVSAK DKGTGREQQI VIQSSGGLSK DDIENMVKNA EKYAEEDRRK KERVEAVNMA EGIIHDTETK MEEFKDQLPA DECNKLKEEI SKMRELLARK DSETGENIRQ AASSLQQASL KLFEMAYKKM ASEREGSGSS GTGEQKEDQK EEKQ
• Sequence Similarities: Belongs to the heat shock protein 70 family.

Gene Information

• Gene Name: HSPA9 heat shock 70kDa protein 9 (mortalin) [ Homo sapiens ]
• Official Symbol: HSPA9
• Synonyms: HSPA9; heat shock 70kDa protein 9 (mortalin); heat shock 70kDa protein 9B (mortalin 2) , HSPA9B; stress-70 protein, mitochondrial; GRP75; mot 2; mthsp75; PBP74
• Gene ID: 3313
• mRNA Refseq: NM_004134
• Protein Refseq: NP_004125
• MIM: 600548
• Uniprot ID: P38646
• Chromosome Location: 5q31.1
• Pathway: RNA degradation, organism-specific biosystem; RNA degradation, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem
• Function: ATP binding; nucleotide binding; protein binding; unfolded protein binding

Reviews

11/01/2019

Quick and reliable protein sequencing; invaluable for our work.

05/05/2019

High-quality protein crystallography services; exceptional results.

11/16/2018

Critical expertise in protein engineering; unmatched service quality.

Q&As

How do environmental factors like heat shock and toxins affect the expression and function of HSPA9?

Environmental stressors like heat shock and toxins alter HSPA9 expression, impacting its protective roles in cells.

How does HSPA9 influence immune cell function and inflammatory responses?

HSPA9 influences immune cell functionality and modulates inflammatory responses, impacting immune regulation.

What role does HSPA9 play in the pathogenesis of neurodegenerative diseases, such as Parkinson's and Alzheimer's?

HSPA9 is implicated in neurodegenerative diseases, potentially affecting protein misfolding and mitochondrial dysfunction.

What is the impact of HSPA9 dysregulation on cancer cell proliferation and survival?

Dysregulation of HSPA9 can lead to enhanced cancer cell proliferation and survival, affecting tumor growth.

What are the mechanisms by which HSPA9 contributes to the cellular aging process?

HSPA9 plays a role in cellular aging by influencing mitochondrial function and stress response mechanisms.

How does HSPA9 interact with other molecular chaperones in protein folding and prevention of protein aggregation?

HSPA9 cooperates with other chaperones in protein folding and prevents harmful protein aggregation.

How does HSPA9 regulate mitochondrial function and cellular stress responses?

HSPA9 is essential for mitochondrial function and helps cells respond to stress by regulating mitochondrial integrity and signaling.