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Official Full Name heat shock 70kDa protein 1B
Background This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
Synonyms HSPA1B; heat shock 70kDa protein 1B; heat shock 70kD protein 1B; heat shock 70 kDa protein 1A/1B; HSP70 2; HSP70-1/HSP70-2; HSP70.1/HSP70.2; heat shock 70 kDa protein 1/2; HSPA1A; HSP70-2; HSP70-1B; FLJ54328
    • Species :
    • Cattle
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSPA1B-28995TH Recombinant Human HSPA1B E.coli N/A
    Human HSPA1B-29395TH Recombinant Human HSPA1B, His-tagged E.coli His
    Human HSPA1B-29397TH Recombinant Human HSPA1B E.coli N/A
    Human HSPA1B-29399TH Recombinant Human HSPA1B, His-tagged His
    Human HSPA1B-29401TH Recombinant Human HSPA1B N/A
    Human HSPA1B-29402TH Recombinant Human HSPA1B E.coli N/A
    Human HSPA1B-5102H Recombinant Human HSPA1B Protein, GST-tagged Wheat Germ GST
    Mouse Hspa1b-403M Recombinant Mouse Hspa1b Protein, His-tagged E.coli His
    Mouse HSPA1B-7905M Recombinant Mouse HSPA1B Protein Mammalian Cell His
    Cattle HSPA1B-402C Recombinant Cattle HSPA1B Protein, His-tagged E.coli His

    hspa1b involved in several pathways and played different roles in them. We selected most pathways hspa1b participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with hspa1b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Spliceosome PPIH; PHF5A; FAM120B; ALYREF; LSM7; SRSF4; CDC40; SRSF2A; XAB2; PRPF19
    MAPK signaling pathway MAP2K4; RAP1AB; MAPK14B; PDGFA; MAPK3; MAP3K6; CD14; MYCB; HRAS; MKNK2B
    Protein processing in endoplasmic reticulum UBE2J2; HNF4B; RAD23B; SEC24B; CCDC102A; ERP29; EIF2AK3; MAPK8B; PARK2; VIMP
    Endocytosis GRK5; ERBB3B; PSD; CAPZA1A; ASAP1A; SH3GLB2A; ARF3A; CDC42L2; VPS29; CBLC
    Antigen processing and presentation KIR3DL1; KIR3DL2; PSME1; HSPA4; KIR2DS4; LGMN; HLA-DOA; HLA-DQA2; IFNG; H2-AA
    Estrogen signaling pathway PIK3R5; KRAS; SHC2; PLCB4; MMP2; PRKACG; NRAS; SHC1; MMP9; SOS1
    Legionellosis HSPA2; C3; HSPA8; CXCL1; PYCARD; CXCL3; ITGAM; IL-8; HSPA1B; Itgam&Itgb2
    Toxoplasmosis NFKBIA; AKT1; MAPK8; HLA-DRB3; GNAI3; LAMA2; MAP3K7; HLA-DOB; STAT1; MAPK9
    Measles IL6; IL12B; DDX58; HSPA1L; TNFSF10; IFNA5; IL2RG; Ifna15; TNFRSF10B; IFNA12
    Influenza A CYCS; IFNA21; HSPA8; HSPA6; HLA-DMB; NXF1; SLC25A6; HSPA2; PIK3R3; OAS1B
    Epstein-Barr virus infection CCNA1; POLR2A; TRAF5; POLR2J3; HLA-DRB4; PSMD8; EIF2AK3; IL10RA; HLA-DRB3; HSPA2

    hspa1b has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by hspa1b itself. We selected most functions hspa1b had, and list some proteins which have the same functions with hspa1b. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding UBE2D2; MCM6; BTK; UBA6; ACTC1B; RTCD1; GSK3B; LIG1; AK1; P2RX2
    ATPase activity, coupled HSPA1A; MYH3; HSPA6; PEX1; VPS4A; CCT8; NSF; HSPA8; HSPA1B; MYO1E
    C3HC4-type RING finger domain binding DNAJA1; HSPA1B; HSPA1A; PINK1; KCNH2; HSPA8
    G-protein coupled receptor binding RSPO3; GNA11B; SFTPBB; PSAP; GNA11A; NMS; RSPO4; SFTPB; GNAT3; GNA13A
    enzyme binding CAD; DAXX; ACAT1; FAM84B; TOP2A; GSTM3; TP53; WWOX; DNM2; PTEN
    heat shock protein binding NFKBIA; FKBP4; EEF1D; DNAJC7; SSUH2.2; PPID; GM5506; HSPA9; HDAC2; DNAJA2L
    protein binding NKX2-5; PRPF8; FRMPD4; EIF4EBP1; RIPK3; MRPL51; LILRA4; COL6A5; ZCCHC12; SYT11
    protein binding involved in protein folding HSPA1B; CLGN; RIC3; HSPA1A; PDCL3; PFDN2; CALR; CD74; CALR3; DNAJB8
    receptor binding RCHY1; ARPP19; DAO; PLAT; STOML2; LTB; Itga10&Itgb1; CNTFR; MAP7; WNT4A
    ubiquitin protein ligase binding SCAMP3; ANKRD32; TCEB2; MDM2; UBE2R2; ZFP746; RANGAP1; UBE2L3; CALR; MC1R
    unfolded protein binding CRYABB; SYVN1; SSUH2.2; TBCA; HSP90B1; DNAJA2L; GRPEL2; DNAJB8; HSPA1L; TOMM20
    virus receptor activity NPC1; SLC52A2; ANPEP; ITGB5; CD46; ITGA2; SLC1A5; SLAMF1; HAVCR1; TNFRSF4

    hspa1b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hspa1b here. Most of them are supplied by our site. Hope this information will be useful for your research of hspa1b.


    Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
    Lenna, S; Townsend, DM; et al. HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells. JOURNAL OF IMMUNOLOGY 184:4654-4661(2010).

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