HSPA1B

  • Official Full Name

    heat shock 70kDa protein 1B

  • Overview

    This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

  • Synonyms

    HSPA1B;heat shock 70kDa protein 1B;heat shock 70kD protein 1B;heat shock 70 kDa protein 1A/1B;HSP70 2;HSP70-1/HSP70-2;HSP70.1/HSP70.2;heat shock 70 kDa protein 1/2;HSPA1A;HSP70-2;HSP70-1B;FLJ54328

Recombinant Proteins

  • Human
  • Cattle
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • GST
  • SUMO
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
HSPA1B-29395TH Recombinant Human HSPA1B, His-tagged E.coli Human His Full L.
HSPA1B-29397TH Recombinant Human HSPA1B E.coli Human Non Full L.
HSPA1B-29399TH Recombinant Human HSPA1B, His-tagged Human His Full L.
HSPA1B-29401TH Recombinant Human HSPA1B Human Non Full L.
HSPA1B-29402TH Recombinant Human HSPA1B E.coli Human Non Full L.
HSPA1B-402C Recombinant Cattle HSPA1B Protein, His-tagged E.coli Cattle His Met1~Asp641
Hspa1b-403M Recombinant Mouse Hspa1b Protein, His-tagged E.coli Mouse His Met1~Asp642
HSPA1B-5102H Recombinant Human HSPA1B Protein, GST-tagged Wheat Germ Human GST
HSPA1B-7905M Recombinant Mouse HSPA1B Protein Mammalian Cells Mouse His
HSPA1B-2623H Recombinant Human HSPA1B protein(381-610 aa), C-His-tagged E.coli Human His 381-610 aa
Hspa1b-3057M Recombinant Mouse Hspa1b protein, His-SUMO-tagged E.coli Mouse His&SUMO 2-642aa
HSPA1B-4355M Recombinant Mouse HSPA1B Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HSPA1B-4355M-B Recombinant Mouse HSPA1B Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HSPA1B involved in several pathways and played different roles in them. We selected most pathways HSPA1B participated on our site, such as Spliceosome,MAPK signaling pathway,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis CYTH1,DAB2,ASAP1,RAB10,RAB35,CDC42,HRAS,GRK7,ARF1L,CCR5
    Measles CCND2,IFNA12,PIK3R1,PIK3CB,AKT1,PRKCQ,NFKBIB,IFNA6,MX1,SLAMF1
    Antigen processing and presentation HLA-DQA2,HLA-DOA,TAPBP,HLA-DRB5,HLA-F,KLRC3,HLA-G,KIR2DS4,NFYC,RFX5
    Estrogen signaling pathway SP1,PLCB4,GABBR2,AKT2,GNAS,CALML5,ITPR3,HSPA2,CREB3L2,KCNJ9
    Legionellosis CLK1,NAIP6,NFKB2,TLR2,IL1B,TNF,CASP7,CXCL2,HSPA8,Itgam&Itgb2
    Protein processing in endoplasmic reticulum MARCH6,NSFL1C,EIF2S1B,DNAJC3A,VIMP,CRYAB,HSP90AA1.2,UBQLN4,UBE2D3,CAPN1B
    Toxoplasmosis Toxoplasma Gondii Profilin Family Protein,IFNGR2,GNAI1,IRGM,BAD,MAPK9,LAMA2,MAPK1,HSPA6,BCL2
    Influenza A IFNA7,ICAM1,IRF3,HSPA8,IFNA2,HLA-DRB3,XPO1,MAP2K6,FURIN,IFNA21
    Epstein-Barr virus infection IL10RA,HDAC5,IL10RB,POLR2A,POLR2I,HLA-DQA2,TBPL1,PIK3CD,PIK3CB,GTF2E1

    Protein Function

    HSPA1B has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1B itself. We selected most functions HSPA1B had, and list some proteins which have the same functions with HSPA1B. You can find most of the proteins on our site.

    Function Related Protein
    ATPase activity DQX1,ABCB1A,KIF15,ABCG4B,PSMC6,ABCB4,ABCA5,PICK1,ATAD2,ABCB6A
    C3HC4-type RING finger domain binding DNAJA1,HSPA1A,HSPA8,PINK1,KCNH2
    ATP binding KIF5A,CDK8,CAMK1DB,NAIP1,CAMKK1B,ADCY9,TIMM44,DMC1,TEP1,MVD
    heat shock protein binding PARK2,DAXX,DMPK,FKBP5,SSUH2.2,DLST,IRAK1,BCOR,PPP5C,HSPA6
    ubiquitin protein ligase binding Fzd4,CUL9,TRAF4,RALB,SLC25A5,NEDD8,SUMO1,NFKBIA,MYOD1,FANCL
    protein binding involved in protein folding HSPA1A,CLGN,CALR3,PFDN1,PFDN2,CD74,PDCL3,DNAJB8,CALR,RIC3
    receptor binding PTK2B,MIF,CRH,PVRL3B,ICOSLG,HIST2H3C2,TNFSF13,PSPN,LTB,DIAPH1
    ATPase activity, coupled VPS4B,HSP104,NSF,HSPA6,PEX1,MYH3,MYO1E,VPS4A,HSPA8,CCT8
    protein binding MTMR6,PRPF3,MAST2,RNF168,KHDC3,DDX31,SDCCAG8,URM1,RAB9B,ADAM15

    Interacting Protein

    HSPA1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1B.

    EGFR;STUB1;SNCA;HSP90AA1

    Resources

    References

    • Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
    • Lenna, S; Townsend, DM; et al. HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells. JOURNAL OF IMMUNOLOGY 184:4654-4661(2010).

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