hspa2

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hspa2

Official Full Name heat shock 70kDa protein 2
Background Heat shock proteins (HSPs) are an important part of the cell's machinery for protein folding and help to protect cells from stress. HSPs are expressed in response to a wide variety of physiological and environmental insults including anticancer chemotherapy, thus allowing some cells to survive near lethal conditions. HSPs are expressed in tumor cell proliferation, differentiation, invasion and metastasis. In addition to improving overall protein integrity, HSP70 directly inhibits apoptosis, and has been shown to be involved in a protective role against thermal stress and cytotoxic drugs. Recently HSP70 has been reported as a prognostic marker in breast, prostate, lung and liver cancer patients
Synonyms HSPA2; heat shock 70kDa protein 2; heat shock 70kD protein 2; heat shock-related 70 kDa protein 2; HSP70-2; HSP70-3
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • S
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSPA2-001H Recombinant Human HSPA2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Hspa2-1188M Recombinant Mouse Hspa2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HSPA2-6536H Recombinant Human HSPA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HSPA2-13986H Recombinant Human HSPA2, GST-tagged E.coli GST
    Human HSPA2-27082TH Recombinant Human HSPA2 E.coli N/A
    Human HSPA2-5105H Recombinant Human HSPA2 Protein, GST-tagged Wheat Germ GST
    Human HSPA2-5355HCL Recombinant Human HSPA2 293 Cell Lysate HEK293 N/A
    Human HSPA2-8255H Recombinant Human HSPA2 protein, His-tagged E.coli His
    Mouse HSPA2-7907M Recombinant Mouse HSPA2 Protein Mammalian Cell His
    Rat HSPA2-2946R Recombinant Rat HSPA2 Protein Mammalian Cell His
    Rat Hspa2-8256R Recombinant Rat Hspa2 protein, His & S-tagged E.coli His/S
    Chicken HSPA2-1728C Recombinant Chicken HSPA2 Mammalian Cell His

    hspa2 involved in several pathways and played different roles in them. We selected most pathways hspa2 participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with hspa2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Spliceosome U2AF2B; HNRNPA1B; SFRS3B; THOC4; TCERG1; HNRPKL; MAGOH; SYF2; THOC2; NHP2L1A
    MAPK signaling pathway MAP2K4A; CACNA2D4; PPP3R1B; RPS6KA5; MAPK8; CACNA1DA; MAPK10; CACNA1BA; GRB2A; TGFBR1B
    Protein processing in endoplasmic reticulum DNAJC1; CAPN1B; CUL1; MARCH6; HYOU1; RNF5; ATF4B1; HSPA2; RAD23B; PPP1R15A
    Endocytosis CAPZA1A; WAS; STAMBPA; NTRK1; TGFBR1A; LDLRA; VPS35; ARPC5LA; SMAP1; PARD6A
    Antigen processing and presentation TAPBP; NFYC; HLA-DOB; TAP1; RFXAP; HLA-DRB4; CALR; TAP2; HLA-DPB1; CD74
    Estrogen signaling pathway HSPA1B; PIK3CA; PRKACG; PLCB3; CREB5; MAP2K2; SOS1; SHC4; ESR2; PLCB4
    Legionellosis APAF1; HSPA1B; SAR1B; C3; IL1B; PYCARD; ITGB2L; TLR5; CXCL3; HBS1L
    Toxoplasmosis HLA-DMA; LDLR; HLA-DRB4; RELA; GNAI1; NFKBIB; HSPA6; MAPK11; MAP3K7; NOS2
    Measles IRAK1; HSPA6; EIF2AK3; IL2RB; PIK3R5; CD209C; EIF2AK4; CLEC4M; IFNGR2; TNFRSF10B
    Influenza A TNFSF10; HLA-DMA; TNFRSF10D; PIK3CD; IFNA4; MAPK1; MAP2K3; IL18; STAT1; TNFRSF10C
    Epstein-Barr virus infection TBPL1; TAB1; VIM; IL10RB; SPI1; EIF2AK3; PSMC2; MAPK8; HLA-E; RELB

    hspa2 has several biochemical functions, for example, ATP binding, enzyme binding, glycolipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hspa2 itself. We selected most functions hspa2 had, and list some proteins which have the same functions with hspa2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TSSK4; ABL1; NLRP5; MYO3A; ZRANB3; P2RX8; UCKL1; JAK2B; DNAJA3; RUVBL2
    enzyme binding USF1; CNTNAP2; DYM; IL6R; SNX12; CAV1; ITGB3; CYP2C19; PPP1R3B; MST1R
    glycolipid binding PLEKHA8P1; GLTPD1; HSPA2; CLEC4F; GLTPD2; CPTP; GLTP; PRRC2B; CD1C; PLEKHA8
    protein binding CMTM3; TRIM2; FKBPL; SIRT6; AP3S1; PELI2; GTSE1; SYT6; MUC7; WIF1
    unfolded protein binding AIPL1; AIP; DNAJA3A; PDRG1; PFDN6; RP2; TOMM20; CCT6A; CCT6B; DNAJB1B

    hspa2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hspa2 here. Most of them are supplied by our site. Hope this information will be useful for your research of hspa2.

    HSPBP1; TRIM38; BAG4; q96be0_human; RIPK2; PPP1CC; HSF2; PSMD2; q53fc7_human; UNC45B; HSPH1

    Sun, J; Wang, J; et al. Knockdown of Polycomb-Group RING Finger 6 Modulates Mouse Male Germ Cell Differentiation in Vitro. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 35:339-352(2015).
    Motiei, M; Tavalaee, M; et al. Evaluation of HSPA2 in fertile and infertile individuals. ANDROLOGIA 45:66-72(2013).

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