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Official Full Name heat shock 70kDa protein 1A
Background HSPA1A, a stress response protein belongs to the HSP70 family. In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
Synonyms Heat Shock 70 kD Protein 1A; HSP70-1; HSPA1
    • Species :
    • Cattle
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • E. coli.
    • E.coli
    • HEK293
    • HEK293T
    • Insect cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSPA1A-066H Recombinant Human HSPA1A Protein, His-tagged Insect cell His
    Human HSPA1A-067H Recombinant Human HSPA1A Protein, His-tagged E. coli His
    Human HSPA1A-012H Recombinant Human HSPA1A Protein, His-tagged Insect Cell His
    Human HSPA1A-015H Recombinant Human HSPA1A Protein, His-tagged E.coli His
    Human HSPA1A-1854H Recombinant Human HSPA1A, His-tagged E.coli His
    Human HSPA1A-2198H Recombinant Human HSPA1A Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HSPA1A-266H Recombinant Human HSPA1A E.coli N/A
    Human HSPA1A-321H Recombinant Human Heat Shock 70 kDa Protein 1A E.coli His
    Human HSPA1A-426H Recombinant Human HSP70 Protein, His-tagged HEK293 His
    Human HSPA1A-4850H Recombinant Human heat shock 70kDa protein 1A, GST-tagged E.coli GST
    Human HSPA1A-4851H Recombinant Human heat shock 70kDa protein 1A, His-tagged Sf9 Insect Cell His
    Human HSPA1A-519HCL Recombinant Human HSPA1A cell lysate Insect Cell N/A
    Human HSPA1A-526H Recombinant Human HSPA1A protein, His-tagged E.coli His
    Human HSPA1A-6950H Recombinant Human HSPA1A, His tagged Insect Cell His
    Mouse Hspa1a-1482M Recombinant Mouse Hspa1a protein, His-tagged E.coli His
    Mouse Hspa1a-3452M Recombinant Mouse Hspa1a Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat Hspa1-001R Recombinant Rat Hspa1a/Hspa1b Protein E. coli. N/A
    Rat HSPA1A-2944R Recombinant Rat HSPA1A Protein Mammalian Cell His
    Cattle HSPA1A-1481C Recombinant Cattle HSPA1A protein, His-tagged E.coli His

    hspa1a involved in several pathways and played different roles in them. We selected most pathways hspa1a participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with hspa1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Spliceosome DHX15; SYF2; SF3B5; SF3A1; PLRG1; SRSF5B; DDX39B; HNRNPUB; THOC3; DDX5
    MAPK signaling pathway CACNB4A; MAP2K6; AKT3A; RASGRF2; PAK2A; MAP2K4A; MEF2C; PAK1; TGFBR1B; TGFB1A
    Protein processing in endoplasmic reticulum UBE2J2; SEC62; SKP1; UBE2D2A; DNAJB1; NPLOC4; AMFR; DNAJC5GA; RNF185; SAR1B
    Endocytosis F2R; PDCD6IP; CBLC; VPS26B; RAB4A; ASAP3; HRASA; TGFB2; GRK7B; EPS15
    Antigen processing and presentation CD8B; KIR2DS3; KIR3DL1; PSME1; HLA-DOA; HSPA6; KLRC4; H2-AB1; PSME2; KIR2DS4
    Estrogen signaling pathway PRKCD; GNAI1; ITPR1; CALM1; HSPA2; CALM4; GPR30; SHC2; CREB3L2; ITPR3
    Prion diseases MAP2K1; C7; C8B; C8G; LOC100033925; ELK1; MAP2K2; IL1A; C9; IL6
    Legionellosis HSPA8; NFKB2; HSPA2; RELA; BNIP3; CASP1; CXCL1; RAB1A; TLR2; PYCARD
    Toxoplasmosis PPIF; TYK2; BIRC3; CD40LG; HLA-DRB3; NOS2; LAMA2; TNF; Toxoplasma Gondii Profilin Family Protein; MAPK11
    Measles PIK3CA; TRP53; IL1B; PIK3R5; TLR9; Il2; FCGR2B; CD209A; IFNA8; OAS1A
    Influenza A EIF2AK2; IL18; GSK3B; IL8L1; RSAD2; RAE1; IFNB; MAPK3; IFIH1; PRKCB
    Epstein-Barr virus infection PIK3R2; CCNA2; RIPK1; POLR2E; EIF2AK2; MAPK11; HDAC4; YWHAE; HLA-DRB5; GTF2B

    hspa1a has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by hspa1a itself. We selected most functions hspa1a had, and list some proteins which have the same functions with hspa1a. You can find most of the proteins on our site.

    Function Related Protein
    ATPase activity ATAD1; MACF1; ABCC8; DNAHC8; NSF; PSMC6; ENTPD2; KIF12; ABCF1; PSMD6
    ATPase activity, coupled HSPA8; HSPA1A; CCT8; HSPA1B; PEX1; HSPA6; VPS4B; NSF; ABCB1A; MYH3
    C3HC4-type RING finger domain binding HSPA1A; HSPA1B; PINK1; KCNH2; HSPA8; DNAJA1
    G-protein coupled receptor binding PYY; GNAI2; GNA14; GNA15.1; GNA11B; PARK2; GNAT2; DNAJA1; RLN3; SFTPB
    enzyme binding TSPAN5; PLCB1; DVL1; HDAC3; HSPA8; TP53; RCOR3; KIAA1967; KRT79; BACE1
    heat shock protein binding LIMK1; TOMM34; CDC37L1; DNAJB6; TPR; TFAM; PDXP; DNAJA2; GRXCR2; HDAC2
    protein binding SESN2; S100B; BCL2L1; CCDC167; STAMBP; KCNJ5; ADAM17; BCAS2; ZHX2; GATAD2A
    protein binding involved in protein folding DNAJB8; PFDN1; HSPA1A; CALR; PDCL3; CLGN; RIC3; HSPA1B; CD74; CALR3
    receptor binding EDA; PRDX5; ECI2; ADM; WNT7AA; CROT; TNFSF12; HSPA1B; LRRC4B; ITGA1
    ubiquitin protein ligase binding CUL1B; SMAD3; EGFR; BCL10; USP13; DBT; SNCAIP; TRAF4; DTX1; USP25
    unfolded protein binding CDC37L1; NPM1; RP2; CLGN; CLPX; CLN3; DNAJA3B; HSPD1; DNAJB1B; ERO1LB
    virus receptor activity PVRL4; CD80; TNFRSF4; ITGB6; ITGB7; SERPINB4; CLEC5A; CR1; SLC52A2; CD46

    hspa1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hspa1a here. Most of them are supplied by our site. Hope this information will be useful for your research of hspa1a.


    Castro, GN; Cayado-Gutierrez, N; et al. Effects of temozolomide (TMZ) on the expression and interaction of heat shock proteins (HSPs) and DNA repair proteins in human malignant glioma cells. CELL STRESS & CHAPERONES 20:253-265(2015).
    Ortner, V; Ludwig, A; et al. An artificial HSE promoter for efficient and selective detection of heat shock pathway activity. CELL STRESS & CHAPERONES 20:277-288(2015).

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