HSPA1L

  • Official Full Name

    heat shock 70kDa protein 1-like

  • Overview

    This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein.

  • Synonyms

    HSPA1L;heat shock 70kDa protein 1-like;heat shock 70kD protein like 1;heat shock 70 kDa protein 1-like;HSP70 HOM;hum70t;heat shock 70 kDa protein 1L;heat shock 70kD protein-like 1;heat shock 10kDa protein 1-like;heat shock 70 kDa protein 1-Hom;H

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • Yeast
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
HSPA1L-13985H Recombinant Human HSPA1L, GST-tagged E.coli Human GST C-term-300a.a.
HSPA1L-3226H Recombinant Human HSPA1L protein, His-tagged E.coli Human His 342-641 aa
HSPA1L-1452H Recombinant Human HSPA1L protein, His-tagged E.coli Human His Met1~Asp641
Hspa1l-1453R Recombinant Rat Hspa1l protein, His-tagged E.coli Rat His Met1~Asp641
HSPA1L-27084TH Recombinant Human HSPA1L Wheat Germ Human Non 641 amino acids
HSPA1L-2945R Recombinant Rat HSPA1L Protein Mammalian Cells Rat His
HSPA1L-5103H Recombinant Human HSPA1L Protein, GST-tagged Wheat Germ Human GST
HSPA1L-5356HCL Recombinant Human HSPA1L 293 Cell Lysate HEK293 Human Non
HSPA1L-241HF Recombinant Full Length Human HSPA1L Protein In Vitro Cell Free System Human Full L. 641 amino acids
HSPA1L-2600R Recombinant Rat HSPA1L Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
HSPA1L-2600R-B Recombinant Rat HSPA1L Protein Pre-coupled Magnetic Beads HEK293 Rat
HSPA1L-3370H Recombinant Human HSPA1L Protein (Met1-Asp641), His tagged E.coli Human His Met1-Asp641
HSPA1L-3814HF Recombinant Full Length Human HSPA1L Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 641 amino acids
Hspa1l-4713M Recombinant Mouse Hspa1l protein, His-sumostar-tagged Yeast Mouse His

    Involved Pathway

    HSPA1L involved in several pathways and played different roles in them. We selected most pathways HSPA1L participated on our site, such as Spliceosome,MAPK signaling pathway,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis NEDD4L,LDLRA,SNX5,LDLRAP1A,HLA-F,EPS15,ARPC5L,GRK1B,WASB,IGF1RA
    Antigen processing and presentation RFX5,CALR,HSPA4,KLRD1,HSP90AB1,KIR2DL3,KIR2DL1,CTSS,RFXAP,CTSB
    Spliceosome HNRNPA1L2,USP39,HNRPK,HSPA8,PRPF3,DHX15,PRPF40A,SNRPA,PRP19,CCDC12
    MAPK signaling pathway MAP2K2B,GNG12,CACNA2D4,PPM1A,MAPKAPK2A,CDC42L,CACNA1SB,FGFR4,FGF6,RAP1AA
    Legionellosis CXCL2,EEF1G,ITGAM,PYCARD,VCP,IL1B,SEC22B,IL-8,NAIP6,NAIP1
    Protein processing in endoplasmic reticulum UBE2G2,UBQLNL,NFE2L2,SAR1AB,PDIA4,NFE2L2A,XBP1,HSP90B1,HSP90AA1.1,DNAJB11
    Measles TNFRSF10C,CD28,TNFRSF10B,STAT5B,TNFSF10,IL2RB,RAB9B,TBK1,IL12B,AKT1
    Toxoplasmosis IKBKG,IRAK4,BCL2,IL10RB,TGFB2,STAT3,TLR4,HLA-DOA,MAPK9,MYD88
    Epstein-Barr virus infection MAPK8,EIF2AK2,HLA-B,TNFAIP3,PIK3CA,PIK3R1,SNW1,IKBKB,TBK1,MAPK11

    Protein Function

    HSPA1L has several biochemical functions, for example, ATP binding,heat shock protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1L itself. We selected most functions HSPA1L had, and list some proteins which have the same functions with HSPA1L. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin protein ligase binding SQSTM1,PTPN22,UBE2H,TNFRSF14,TRIB2,EGR2,TRIM28,ASB4,C10orf46,GGN
    unfolded protein binding AIPL1,PPIB,CLGN,NPM1,CANX,CALR,CCT2,CHAF1B,NAP1L4,GRPEL1
    protein binding HLCS,DDX47,KRIT1,HOXA5,NARG1,TFAP2B,ADAM8,HUS1,ADIPOQ,COG8
    ATP binding CSF1RA,MERTK,KIF7,JAK2A,ATP8A1,ATP1A3,CHEK1,CDC42BPG,ATP8B5,PTK6
    heat shock protein binding FKBP5,GPR37,HSPA6,HSPA1B,TFAM,FAF1,APAF1,LIMK1,DNAJB6,CDC37

    Interacting Protein

    HSPA1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1L here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1L.

    TP53;TRAF2;MAP3K1;TAB1;NFKB2;NFKBIE;IKBKB;MAP3K7;MAP3K7;RIPK2;TNFRSF1A;NFKB1;TNFRSF1B;NFKBIA;MAP3K8;YWHAZ

    Resources

    References

    • Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
    • Zhang, XM; Tanguay, RM; et al. Variants of HSPA1A in Combination with Plasma Hsp70 and Anti-Hsp70 Antibody Levels Associated with Higher Risk of Acute Coronary Syndrome. CARDIOLOGY 119:57-64(2011).

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