HSPA1L
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Official Full Name
heat shock 70kDa protein 1-like -
Overview
This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. -
Synonyms
HSPA1L;heat shock 70kDa protein 1-like;heat shock 70kD protein like 1;heat shock 70 kDa protein 1-like;HSP70 HOM;hum70t;heat shock 70 kDa protein 1L;heat shock 70kD protein-like 1;heat shock 10kDa protein 1-like;heat shock 70 kDa protein 1-Hom;H
Recombinant Proteins
- Human
- Rat
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HSPA1L-13985H | Recombinant Human HSPA1L, GST-tagged | E.coli | Human | GST | C-term-300a.a. | |
| HSPA1L-3226H | Recombinant Human HSPA1L protein, His-tagged | E.coli | Human | His | 342-641 aa | |
| HSPA1L-1452H | Recombinant Human HSPA1L protein, His-tagged | E.coli | Human | His | Met1~Asp641 |
|
| Hspa1l-1453R | Recombinant Rat Hspa1l protein, His-tagged | E.coli | Rat | His | Met1~Asp641 |
|
| HSPA1L-27084TH | Recombinant Human HSPA1L | Wheat Germ | Human | Non | 641 amino acids |
|
| HSPA1L-2945R | Recombinant Rat HSPA1L Protein | Mammalian Cells | Rat | His |
|
|
| HSPA1L-5103H | Recombinant Human HSPA1L Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| HSPA1L-5356HCL | Recombinant Human HSPA1L 293 Cell Lysate | HEK293 | Human | Non |
|
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| HSPA1L-241HF | Recombinant Full Length Human HSPA1L Protein | In Vitro Cell Free System | Human | Full L. 641 amino acids |
|
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| HSPA1L-2600R | Recombinant Rat HSPA1L Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
|
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| HSPA1L-2600R-B | Recombinant Rat HSPA1L Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HSPA1L-3370H | Recombinant Human HSPA1L Protein (Met1-Asp641), His tagged | E.coli | Human | His | Met1-Asp641 |
|
| HSPA1L-3814HF | Recombinant Full Length Human HSPA1L Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 641 amino acids |
|
Involved Pathway
HSPA1L involved in several pathways and played different roles in them. We selected most pathways HSPA1L participated on our site, such as Spliceosome,MAPK signaling pathway,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Estrogen signaling pathway | ITPR1,CREB3L1,PLCB2,GRB2,FKBP5,PIK3CB,AKT1,Adcy4,NRAS,HSPA6 |
| Influenza A | BMA2,AKT2,MAVS,TNFRSF10B,ACTB,IFNA12,PRKCA,TNFRSF10D,PRKCB,IFNAR2 |
| Protein processing in endoplasmic reticulum | STT3B,UBE2D2,GANAB,UBQLNL,TUSC3,ATXN3,PDIP5,CRYABA,ERP29,UBE2D4 |
| Endocytosis | AP2M1B,CDC42L,RHOAB,ARAP1,RHOAA,SMAD3A,KIF5B,FAM125A,CAPZA1A,TGFB2 |
| Measles | HSPA6,IL6,CCNE1,cgr2b,IRF3,IKBKE,CD46,SLAMF1,IFIH1,Cd209g |
| Spliceosome | SRSF3,SRSF5A,HSPA1B,PPIL1,LSM7,MAGOH,SRSF4,SNRPD1,BAT1,PQBP1 |
| Toxoplasmosis | LAMB4,IL10RB,HLA-DQB1,HSPA1B,Toxoplasma Gondii Major Surface Antigen P30,PPIF,LY96,PDPK1,STAT3,CD40LG |
| Legionellosis | RAB1,CYCS,EEF1A1,APAF1,IL18,HSF1,SAR1B,MYD88,CR1,HSPA1B |
| MAPK signaling pathway | FGF18A,ATF4B1,PRKACBA,FGF5,CACNA1D,RAC3A,FGFR2,CASP3B,CACNG6,MAP3K2 |
Protein Function
HSPA1L has several biochemical functions, for example, ATP binding,heat shock protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1L itself. We selected most functions HSPA1L had, and list some proteins which have the same functions with HSPA1L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heat shock protein binding | CDC37L1,DLST,GPR37,FKBP5,LMAN2,IRAK1,NFKBIA,DNAJC9,HSPA1A,FAF1 |
| ubiquitin protein ligase binding | UBE2W,AXIN1,FZD6,POU5F1,CDC34B,GSK3B,SCN5A,SMAD7,UBE2KA,TRAF4 |
| protein binding | RANGAP1,KAL1,MATN2,CHMP1A,BCL2L2,XPO7,TRAIP,GAB1,SCO2,MUC5B |
| ATP binding | CDK11A,C22orf28,TLK2,DMPK,ACTR8,GUCY2F,UBE2D4,PNKP,NSFA,PIP4K2B |
| unfolded protein binding | CHAF1A,PFDN6,DNAJB4,DNAJB8,PFDN2,RUVBL2,ERO1LB,CALR3,DNAJB5,SSUH2.2 |
Interacting Protein
HSPA1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1L here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1L.
TP53;TRAF2;MAP3K1;TAB1;NFKB2;NFKBIE;IKBKB;MAP3K7;MAP3K7;RIPK2;TNFRSF1A;NFKB1;TNFRSF1B;NFKBIA;MAP3K8;YWHAZ
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References
- Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
- Zhang, XM; Tanguay, RM; et al. Variants of HSPA1A in Combination with Plasma Hsp70 and Anti-Hsp70 Antibody Levels Associated with Higher Risk of Acute Coronary Syndrome. CARDIOLOGY 119:57-64(2011).
