"PTPN7" Related Products

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Recombinant Human PTPN7

Cat.No.: PTPN7-26538TH
Product Overview: Recombinant fusion protein, corresponding to amino acids 79-358 of Human HePTP / PTPN7.
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene.
Source: E. coli
Tissue specificity: Expressed exclusively in thymus and spleen.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 45% Glycerol, 50mM Tris HCl (pH 8.0), 5mM DTT, 5mM Reduced Glutathione, 150mM Sodium Chloride.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids: Fusion protein comprising amino acids 79-358 of HePTP, tagged at the N-terminus with GST.
Sequence Similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.Contains 1 tyrosine-protein phosphatase domain.
Gene Name: PTPN7 protein tyrosine phosphatase, non-receptor type 7 [ Homo sapiens ]
Official Symbol: PTPN7
Synonyms: PTPN7; protein tyrosine phosphatase, non-receptor type 7; tyrosine-protein phosphatase non-receptor type 7; HEPTP; LC PTP;
Gene ID: 5778
mRNA Refseq: NM_001199797
Protein Refseq: NP_001186726
MIM: 176889
Uniprot ID: P35236
Chromosome Location: 1q32.1
Pathway: Downstream signaling in naive CD8+ T cells, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; Ras signaling in the CD4+ TCR pathway, organism-specific biosystem;
Function: hydrolase activity; protein tyrosine phosphatase activity;

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