ptpn13
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  • Official Full Name
  • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
  • Background
  • A novel protein tyrosine phosphatase, FAP-1 (for FAS-associated phosphatase) (originally designated PTP-BAS), has been shown to associated with the carboxy terminus fifteen amino acids of FAS. Three isoforms of the protein result from alternative RNA splicings, the longest of which encodes a protein 2485 amino aicds in lenghth. Although lacking a transmembrane region, FAP-1 does contain a membrane-binding domain, similar to that found in cytoskeleton-associated proteins such as ezrin. FAP-1 does not seem to associate with CD40 or death domain proteins such as TNF-RI and TNF-RII.
  • Synonyms
  • PTPN13; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); tyrosine-protein phosphatase non-receptor type 13; PTP BAS; PTP BL; PTP1E; PTPL1; hPTPE1; protein-tyrosine phosphatase 1E; protein-tyrosine phosphatase PTPL1; fas-associated protein-tyrosine phosphatase 1; PNP1; FAP-1; PTPLE; PTP-BL; hPTP1E; PTP-BAS; DKFZp686J1497
Cat.#:PTPN13-8097HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN13 protein, His & T7-tagged
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Cat.#:Ptpn13-8098MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ptpn13 protein, His & T7-tagged
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Cat.#:Ptpn13-8099RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ptpn13 protein, His & T7-tagged
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Cat.#:PTPN13-5628ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PTPN13
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Cat.#:PTPN13-463HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN13,GST-tagged,Active
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Cat.#:Ptpn13-337MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Protein Tyrosine Phosphatase, Non-receptor Type 13
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Involved Pathway

PTPN13 involved in several pathways and played different roles in them. We selected most pathways PTPN13 participated on our site, such as Apoptosis Modulation and Signaling, Ephrin B reverse signaling, Fc-epsilon receptor I signaling in mast cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis Modulation and Signaling
BOK; PTRH2; BCL2L10; BCL2L11; DAXX; BAG3; SEPT4; CAPNS1; HRK; PTPN13
Ephrin B reverse signaling
EFNB1; PTPN13; EFNB2
Fc-epsilon receptor I signaling in mast cells
DOK1; PTPN13; LAT2; ITK; S1PR1

Protein Function

PTPN13 has several biochemical functions, for example, phosphatidylinositol 3-kinase regulatory subunit binding, protein binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN13 itself. We selected most functions PTPN13 had, and list some proteins which have the same functions with PTPN13. You can find most of the proteins on our site.
Function
Related Protein
Function phosphatidylinositol 3-kinase regulatory subunit binding
Related Protein FAM83B; PIK3R1; PIK3AP1; DNM2; XBP1; FAM83A; PTPN13
Function protein binding
Related Protein PSEN2; IL6; F3; PSMC2; CIRH1A; PSMD6; SOX9; TEF; TAGLN2; DPYD
Function protein tyrosine phosphatase activity
Related Protein PTPRQ; DUSP9; SSH2; PTP4A2B; PTPN6; MTMR7; MDP1; MTMR1A; CDC25B; LRP8

Interacting Protein

PTPN13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN13 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN13.
RAPGEF6; PKN2; FAS; PLEKHA1; PDCD10