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PTPN1

  • Official Full Name

    protein tyrosine phosphatase, non-receptor type 1

  • Overview

    PTP1B is the prototypic member of the protein tyrosine phosphatase (PTP) family, which comprises at least 37 proteins. The family is characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. The PTPs have high substrate specificity for phosphotyrosyl proteins. At the primary sequence level, PTPs share little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP1B is a negative regulator of insulin and leptin signal transduction and may be a potential therapeutic target for diabetes and obesity. Insulin also influences the expression of splice variants of PTP1B.
  • Synonyms

    PTPN1; protein tyrosine phosphatase, non-receptor type 1; PTP1B; tyrosine-protein phosphatase non-receptor type 1; protein tyrosine phosphatase 1B; protein-tyrosine phosphatase 1B; protein tyrosine phosphatase, placental;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTPN1-31256TH Active Recombinant Human PTPN1 protein, Bioactivity Validated E.coli N/A
Human PTPN1-1517H Active Recombinant Human PTPN1, GST-tagged E.coli GST Full length
Human PTPN1-205H Active Recombinant Human PTPN1(1-321) Protein, N-GST-tagged E. coli GST 1-321 aa
Human PTPN1-537H Recombinant Human PTPN1 E.coli N/A
Human PTPN1-1908H Recombinant Human Protein Tyrosine Phosphatase, Non-Receptor Type 1, GST-tagged E.coli GST
Human PTPN1-460H Recombinant Human PTPN1, GST-tagged, Active Sf9 Insect Cell GST
Human PTPN1-1521H Recombinant Human PTPN1 Human N/A
Human PTPN1-764H Recombinant Human PTPN1, His tagged E.coli His
Human PTPN1-220H Recombinant Human PTPN1 protein, DDK-tagged Insect Cell DDK
Human PTPN1-221H Active Recombinant Human PTPN1 protein, His-tagged E.coli His Glu2-Asn321
Human PTPN1-2686HCL Recombinant Human PTPN1 293 Cell Lysate HEK293 N/A
Human PTPN1-1914H Recombinant Human PTPN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTPN1-1800H-B Recombinant Human PTPN1 Protein Pre-coupled Magnetic Beads HEK293
Human PTPN1-081H Recombinant Human PTPN1 Protein E. coli
Human PTPN1-32H Recombinant Human PTPN1 Protein E.coli 1-321
Human PTPN1-670HFL Recombinant Full Length Human PTPN1 Protein, C-Flag-tagged Mammalian cells Flag
Human PTPN1-3388H Recombinant Human PTPN1 protein, His&Myc-tagged E.coli His&Myc 1-321aa
Human PTPN1-6092H Recombinant Human PTPN1 Protein (Met1-Asn321), N-His tagged E.coli N-His Met1-Asn321
Human PTPN1-1800H Recombinant Human PTPN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ptpn1-455M Recombinant Mouse Ptpn1, GST-tagged E.coli GST
Mouse PTPN1-13674M Recombinant Mouse PTPN1 Protein Mammalian Cell His
Mouse PTPN1-7275M-B Recombinant Mouse PTPN1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ptpn1-5234M Recombinant Mouse Ptpn1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PTPN1-7275M Recombinant Mouse PTPN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ptpn1-456R Recombinant Rat Ptpn1, GST-tagged E.coli GST
Rat PTPN1-4829R Recombinant Rat PTPN1 Protein Mammalian Cell His
Rat PTPN1-4488R-B Recombinant Rat PTPN1 Protein Pre-coupled Magnetic Beads HEK293
Rat PTPN1-4488R Recombinant Rat PTPN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PTPN1-3704R Recombinant Rhesus monkey PTPN1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PTPN1-3521R Recombinant Rhesus Macaque PTPN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PTPN1-3521R-B Recombinant Rhesus Macaque PTPN1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PTPN1-8565Z Recombinant Zebrafish PTPN1 Mammalian Cell His
Chicken PTPN1-6438C Recombinant Chicken PTPN1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PTPN1 involved in several pathways and played different roles in them. We selected most pathways PTPN1 participated on our site, such as Adherens junction, Insulin signaling pathway, Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adherens junctionACTN2B;RHOA;MAPK3;ACTB;ACTN3A;SMAD3A;PTPRFB;ACTN1;NLK
Insulin signaling pathwayGSK3B;FOXO1A;INSRA;MTOR;SOCS2;PHKB;BADB;INS;RHOQ
Insulin resistanceCREB3L2;SOCS3B;RPS6KA6;MTOR;PTPRFB;PTPN11A;RPS6KB2;RPS6KB1B;RPS6KAL

PTPN1 has several biochemical functions, for example, enzyme binding, ephrin receptor binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN1 itself. We selected most functions PTPN1 had, and list some proteins which have the same functions with PTPN1. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingTARBP2;PDCD2;STC2;RCOR1;TSPAN14;ATG3;UGT1A7;UGT1A6;UGT1A1
ephrin receptor bindingEFNA2;SDCBP;PIK3CG;ANKS1B;EFNA1B;FYN;EFNA5B;EFNB1;NTRK1
insulin receptor bindingIGF1R;PTPN11;DOK4;FRS2;PTPN1;INSL3;DOK1B;SHC1;DOK6
poly(A) RNA bindingZNF385A;PSMD4;KHSRP;IPO5;NOL10;MTAP4;DDX31;ZFP768;TFRC
protein bindingDRD1A;MED31;E2F2;CENPT;ZFYVE27;DNA2;EFHA1;RRAGA;FAM50B
protein kinase bindingB4GALT1;RPTOR;RACGAP1;SLC12A7;TOM1L1;PRKAG3;CD3E;MS4A2;PTPN1
protein phosphatase 2A bindingHMGCR;EIF4EBP1;ENSA;PPME1;STRN;BCL2;ENSAA;PTPN1;CTTNBP2NL
protein tyrosine phosphatase activityDUSP13A;DNAJC6;DUSP13;PTPN20;DUSP9;DUSP15;EYA2;CDC25C;DUSP8A
receptor tyrosine kinase bindingNCK1;NRG1;MYOC;SQSTM1;ANGPT2A;PCNA;FNTA;FIZ1;ANGPT2
zinc ion bindingNSD1;RNF215;CXXC4;UNK;POLR1A;PIAS4B;EHMT1A;CRIP2;WHSC1L1

PTPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN1.

INSR

  • Q&As
  • Reviews

Q&As (7)

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What is the impact of altered PTPN1 activity on obesity and related metabolic disorders? 10/12/2022

Altered PTPN1 activity is associated with obesity, as it impacts pathways involved in energy balance and fat storage.

How do genetic variations in PTPN1 contribute to metabolic disease susceptibility? 05/03/2020

Genetic variations in PTPN1 can affect its activity and thereby influence metabolic processes and disease risk.

What role does PTPN1 play in the development of insulin resistance and type 2 diabetes? 04/14/2020

PTPN1 is implicated in insulin resistance, potentially contributing to the development of type 2 diabetes.

How does PTPN1 regulate insulin signaling and glucose metabolism? 12/21/2018

It negatively regulates insulin signaling by dephosphorylating insulin receptor substrates, affecting glucose uptake and metabolism.

How does PTPN1 interact with other signaling molecules in regulating metabolic pathways? 02/15/2018

PTPN1 interacts with various signaling proteins, playing a role in diverse metabolic pathways including lipid and glucose metabolism.

What is the primary function of PTPN1 in cellular signaling? 04/04/2017

PTPN1, also known as Protein Tyrosine Phosphatase Non-Receptor Type 1, is key in dephosphorylating proteins involved in signal transduction.

What potential therapeutic applications could arise from targeting PTPN1 in metabolic diseases? 04/03/2017

Targeting PTPN1 could offer therapeutic benefits in treating insulin resistance, type 2 diabetes, and obesity.

Customer Reviews (3)

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Reviews
04/06/2023

    Timely and precise. Essential for achieving research goals.

    08/30/2020

      Efficient service, valuable insights. Key to research success.

      03/26/2018

        Saves time and resources. Critical for our research.

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