PTPN1
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Official Full Name
protein tyrosine phosphatase, non-receptor type 1
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Overview
PTP1B is the prototypic member of the protein tyrosine phosphatase (PTP) family, which comprises at least 37 proteins. The family is characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. The PTPs have high substrate specificity for phosphotyrosyl proteins. At the primary sequence level, PTPs share little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP1B is a negative regulator of insulin and leptin signal transduction and may be a potential therapeutic target for diabetes and obesity. Insulin also influences the expression of splice variants of PTP1B. -
Synonyms
PTPN1; protein tyrosine phosphatase, non-receptor type 1; PTP1B; tyrosine-protein phosphatase non-receptor type 1; protein tyrosine phosphatase 1B; protein-tyrosine phosphatase 1B; protein tyrosine phosphatase, placental;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Human
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
PTPN1 involved in several pathways and played different roles in them. We selected most pathways PTPN1 participated on our site, such as Adherens junction, Insulin signaling pathway, Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adherens junction | ACTN2B;RHOA;MAPK3;ACTB;ACTN3A;SMAD3A;PTPRFB;ACTN1;NLK |
Insulin signaling pathway | GSK3B;FOXO1A;INSRA;MTOR;SOCS2;PHKB;BADB;INS;RHOQ |
Insulin resistance | CREB3L2;SOCS3B;RPS6KA6;MTOR;PTPRFB;PTPN11A;RPS6KB2;RPS6KB1B;RPS6KAL |
PTPN1 has several biochemical functions, for example, enzyme binding, ephrin receptor binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN1 itself. We selected most functions PTPN1 had, and list some proteins which have the same functions with PTPN1. You can find most of the proteins on our site.
Function | Related Protein |
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enzyme binding | TARBP2;PDCD2;STC2;RCOR1;TSPAN14;ATG3;UGT1A7;UGT1A6;UGT1A1 |
ephrin receptor binding | EFNA2;SDCBP;PIK3CG;ANKS1B;EFNA1B;FYN;EFNA5B;EFNB1;NTRK1 |
insulin receptor binding | IGF1R;PTPN11;DOK4;FRS2;PTPN1;INSL3;DOK1B;SHC1;DOK6 |
poly(A) RNA binding | ZNF385A;PSMD4;KHSRP;IPO5;NOL10;MTAP4;DDX31;ZFP768;TFRC |
protein binding | DRD1A;MED31;E2F2;CENPT;ZFYVE27;DNA2;EFHA1;RRAGA;FAM50B |
protein kinase binding | B4GALT1;RPTOR;RACGAP1;SLC12A7;TOM1L1;PRKAG3;CD3E;MS4A2;PTPN1 |
protein phosphatase 2A binding | HMGCR;EIF4EBP1;ENSA;PPME1;STRN;BCL2;ENSAA;PTPN1;CTTNBP2NL |
protein tyrosine phosphatase activity | DUSP13A;DNAJC6;DUSP13;PTPN20;DUSP9;DUSP15;EYA2;CDC25C;DUSP8A |
receptor tyrosine kinase binding | NCK1;NRG1;MYOC;SQSTM1;ANGPT2A;PCNA;FNTA;FIZ1;ANGPT2 |
zinc ion binding | NSD1;RNF215;CXXC4;UNK;POLR1A;PIAS4B;EHMT1A;CRIP2;WHSC1L1 |
PTPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN1.
INSR
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Q&As (7)
Ask a questionAltered PTPN1 activity is associated with obesity, as it impacts pathways involved in energy balance and fat storage.
Genetic variations in PTPN1 can affect its activity and thereby influence metabolic processes and disease risk.
PTPN1 is implicated in insulin resistance, potentially contributing to the development of type 2 diabetes.
It negatively regulates insulin signaling by dephosphorylating insulin receptor substrates, affecting glucose uptake and metabolism.
PTPN1 interacts with various signaling proteins, playing a role in diverse metabolic pathways including lipid and glucose metabolism.
PTPN1, also known as Protein Tyrosine Phosphatase Non-Receptor Type 1, is key in dephosphorylating proteins involved in signal transduction.
Targeting PTPN1 could offer therapeutic benefits in treating insulin resistance, type 2 diabetes, and obesity.
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