PTPN11

  • Official Full Name

    protein tyrosine phosphatase, non-receptor type 11

  • Overview

    The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified.
  • Synonyms

    PTPN11; protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Sf9 insect cells
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • The N
  • terminal 6XHis
  • AviTag™
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTPN11-31402TH Active Recombinant Human PTPN11 protein, GST-tagged E.coli GST
Human PTPN11-519H Active Recombinant Human PTPN11 Protein, His-tagged E.coli His Ser2-Arg593
Human PTPN11-1518H Active Recombinant Human PTPN11, GST-tagged Sf9 Insect Cell GST 246-593 aa
Human PTPN11-461H Recombinant Human PTPN11, GST-tagged, Active E.coli GST
Human PTPN11-18H Active Recombinant Human PTPN11 Protein, N-terminal 6XHis and AviTag™, Biotinylated E.coli The N-terminal 6XHis and AviTag™ 1-593
Human PTPN11-04H Active Recombinant Human PTPN11 Protein(Full length), N-GST-tagged Sf9 insect cells N-GST Full length
Human PTPN11-6100H Recombinant Human PTPN11 Protein (Met1-Arg593), N-His tagged E.coli N-His Met1-Arg593
Mouse Ptpn11-8674M Active Recombinant Mouse Ptpn11 protein(Met1-Arg593), His-tagged HEK293 C-His Met1-Arg593
Mouse PTPN11-1334MCL Recombinant Mouse PTPN11 cell lysate Human Cell N/A
Mouse Ptpn11-5235M Recombinant Mouse Ptpn11 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PTPN11-4830R Recombinant Rat PTPN11 Protein Mammalian Cell His
Rat PTPN11-4489R Recombinant Rat PTPN11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTPN11-4489R-B Recombinant Rat PTPN11 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PTPN11-3705R Recombinant Rhesus monkey PTPN11 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PTPN11-3522R Recombinant Rhesus Macaque PTPN11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PTPN11-3522R-B Recombinant Rhesus Macaque PTPN11 Protein Pre-coupled Magnetic Beads HEK293
Chicken PTPN11-6527C Recombinant Chicken PTPN11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • PTPN11 Related Signal Pathway

PTPN11 involved in several pathways and played different roles in them. We selected most pathways PTPN11 participated on our site, such as Ras signaling pathway, Phospholipase D signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwaySTK4;RASAL3;PLA2G2F;ANGPT1;PDGFRA;MAPK1;MLLT4;RASSF1;PLA2G10
Phospholipase D signaling pathwayCYTH3;GNA12;GAB1;AVPR2;GRB2;PDGFD;PLCG1;RRAS2;CYTH4
Jak-STAT signaling pathwayIL29;PTPN11B;IL3;PTPN2A;STAT3;PIAS4;M17;IFNG;SOCS1
Natural killer cell mediated cytotoxicityLCK;Raet1a;VAV1;PRKCG;IFNA21;TNF;FAS;TNFRSF10C;IFNA6
Leukocyte transendothelial migrationCLDN17;PIK3R3;ACTN2;MYLPF;MAPK13;ITGAL;CD99;MMP2;CLDN16
Neurotrophin signaling pathwayBRAF;TRAF6;IRAK1;CALM1;PIK3R1;TP73;Fasl;SHC2;RAP1B
Adipocytokine signaling pathwayPRKAG2A;G6PC;SLC2A1;ADIPOR2;PRKAB1B;NFKBIAB;ACSL1A;ADIPOR1B;PTPN11
Insulin resistanceOGT;NR1H3;PTEN;AKT2;PPP1CBL;PRKAG1;CREB3L3;SLC27A1B;CREB3L3L
Epithelial cell signaling in Helicobacter pylori infectionRAC1;LYN;MAPK12;ATP6V0A2;MAPK8;PLCG1;ATP6V1C1;CXCR1;MAP2K4
Herpes simplex infectionCDK1;TAP1;EIF2AK1;POU2F3;TNF;PER3;TTC6;BLB1;DDX58
Proteoglycans in cancerTNF;WNT7B;NUDT16L1;MDM2;MAPK11;MAPK13;RAC1;PTPN6;PLAU
Renal cell carcinomaPIK3CB;FH1;HIF1A;GRB2;TGFB2;SLC2A1;PAK2;TCEB2;HRAS
Chronic myeloid leukemiaPIK3CB;PIK3R5;CDK6;BCR;CRK;PIK3R1;AKT1;CCND1;PIK3R2

PTPN11 has several biochemical functions, for example, D1 dopamine receptor binding, SH3/SH2 adaptor activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN11 itself. We selected most functions PTPN11 had, and list some proteins which have the same functions with PTPN11. You can find most of the proteins on our site.

Function Related Protein
D1 dopamine receptor bindingCAV2;DLG4;ARRB2;GNAS;AGTR1A;ATP1A3;PTPN11;DRD3
SH3/SH2 adaptor activitySRC;CHN2;ARHGAP4;STAM;SH3BGR;SKAP2;IRS4;SKAP1;CRK
insulin receptor bindingPIK3R1;INSL3;DOK4;DOK2;SNX4;IRS1;IGF2;FRS3;DOK1
insulin receptor substrate bindingGRB2;INSR;INSRR;PIK3CB;PRKCZ;INSRA;PRKCD;PIK3CA;JAK2
non-membrane spanning protein tyrosine phosphatase activityACP1;PTPN18;PTPN9;PTPN12;DUSP1;PTPN4;PTPN11
peptide hormone receptor bindingADCYAP1;PTHLHA;PTH;NPPA;FYN;NPPC;JAK2;PTPN11;RUNDC3A
phospholipase bindingAPOC2;SELE;CALM1;PRKCZ;LMNB1;DGKQ;CALM;PTPN11;ARHGAP6
phosphoprotein phosphatase activityPTPRQ;PTPN2A;CTDSPL2A;PTEN;SSH1;PPP1CBL;ACP2;PPP4CB;PTPRK
protein bindingGPS2;GNA14;ADAM10;PCGF3;UBA6;ODF1;PDZD11;DZIP1L;EIF5A
protein domain specific bindingHIST4H4;ARRB2;TBL1X;SHC4;CHMP2A;TNFAIP1;ZNF521;SHROOM2;HIST1H4L
protein tyrosine phosphatase activityDUSP8A;DUSP19;DUPD1;PTPRK;EYA2;CDC14AB;MTMR6;DNAJC6;CDC14C
receptor tyrosine kinase bindingPIK3R2;Flt3l;FIZ1;DOCK4;PCNA;SHC4;FNTA;TOB1;ANGPT2A

PTPN11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN11 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN11.

GAB1

Research Area

Related articles

Bader-Meunier, B; Cave, H; et al. Are RASopathies new monogenic predisposing conditions to the development of systemic lupus erythematosus? Case report and systematic review of the literature. SEMINARS IN ARTHRITIS AND RHEUMATISM 43:217-219(2013).
Jiang, J; Jin, MS; et al. Increased expression of tyrosine phosphatase SHP-2 in Helicobacter pylori-infected gastric cancer. WORLD JOURNAL OF GASTROENTEROLOGY 19:575-580(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there genetic tests available to detect PTPN11 mutations? 12/17/2022

Yes, genetic testing can identify mutations in the PTPN11 gene, providing valuable information for diagnosis and treatment planning.

How does PTPN11 impact cell signaling pathways? 06/21/2022

PTPN11 is involved in various signaling pathways, including the RAS-MAPK pathway, and its mutations can dysregulate these pathways, leading to abnormal cell signaling.

Is PTPN11 involved in normal cellular functions? 02/20/2022

Yes, PTPN11 plays a crucial role in normal cellular functions by regulating the activity of proteins through dephosphorylation.

Can PTPN11 be used as a biomarker for certain diseases? 10/27/2020

Yes, the presence of PTPN11 mutations can serve as a biomarker for specific cancers and developmental disorders.

How is PTPN11 involved in developmental disorders? 02/04/2018

Mutations in PTPN11 can lead to developmental disorders, including Noonan syndrome and LEOPARD syndrome, affecting growth and development.

Customer Reviews (3)

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Reviews
08/01/2020

    Their technical expertise and knowledge of the PTPN11 protein are invaluable resources.

    05/18/2016

      This reliability reduces experimental variability and enhances the accuracy of data interpretation.

      04/11/2016

        the manufacturer's commitment to continuous innovation and development of new tools and technologies ensures that I have access to the latest advancements in PTPN11 protein research.

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