PTPN11
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Official Full Name
protein tyrosine phosphatase, non-receptor type 11
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Overview
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. -
Synonyms
PTPN11; protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Human Cell
- Mammalian Cell
- Sf9 Insect Cell
- Sf9 insect cells
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- The N
- terminal 6XHis
- AviTag™
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- PTPN11 Related Signal Pathway
PTPN11 involved in several pathways and played different roles in them. We selected most pathways PTPN11 participated on our site, such as Ras signaling pathway, Phospholipase D signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | STK4;RASAL3;PLA2G2F;ANGPT1;PDGFRA;MAPK1;MLLT4;RASSF1;PLA2G10 |
| Phospholipase D signaling pathway | CYTH3;GNA12;GAB1;AVPR2;GRB2;PDGFD;PLCG1;RRAS2;CYTH4 |
| Jak-STAT signaling pathway | IL29;PTPN11B;IL3;PTPN2A;STAT3;PIAS4;M17;IFNG;SOCS1 |
| Natural killer cell mediated cytotoxicity | LCK;Raet1a;VAV1;PRKCG;IFNA21;TNF;FAS;TNFRSF10C;IFNA6 |
| Leukocyte transendothelial migration | CLDN17;PIK3R3;ACTN2;MYLPF;MAPK13;ITGAL;CD99;MMP2;CLDN16 |
| Neurotrophin signaling pathway | BRAF;TRAF6;IRAK1;CALM1;PIK3R1;TP73;Fasl;SHC2;RAP1B |
| Adipocytokine signaling pathway | PRKAG2A;G6PC;SLC2A1;ADIPOR2;PRKAB1B;NFKBIAB;ACSL1A;ADIPOR1B;PTPN11 |
| Insulin resistance | OGT;NR1H3;PTEN;AKT2;PPP1CBL;PRKAG1;CREB3L3;SLC27A1B;CREB3L3L |
| Epithelial cell signaling in Helicobacter pylori infection | RAC1;LYN;MAPK12;ATP6V0A2;MAPK8;PLCG1;ATP6V1C1;CXCR1;MAP2K4 |
| Herpes simplex infection | CDK1;TAP1;EIF2AK1;POU2F3;TNF;PER3;TTC6;BLB1;DDX58 |
| Proteoglycans in cancer | TNF;WNT7B;NUDT16L1;MDM2;MAPK11;MAPK13;RAC1;PTPN6;PLAU |
| Renal cell carcinoma | PIK3CB;FH1;HIF1A;GRB2;TGFB2;SLC2A1;PAK2;TCEB2;HRAS |
| Chronic myeloid leukemia | PIK3CB;PIK3R5;CDK6;BCR;CRK;PIK3R1;AKT1;CCND1;PIK3R2 |
PTPN11 has several biochemical functions, for example, D1 dopamine receptor binding, SH3/SH2 adaptor activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN11 itself. We selected most functions PTPN11 had, and list some proteins which have the same functions with PTPN11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| D1 dopamine receptor binding | CAV2;DLG4;ARRB2;GNAS;AGTR1A;ATP1A3;PTPN11;DRD3 |
| SH3/SH2 adaptor activity | SRC;CHN2;ARHGAP4;STAM;SH3BGR;SKAP2;IRS4;SKAP1;CRK |
| insulin receptor binding | PIK3R1;INSL3;DOK4;DOK2;SNX4;IRS1;IGF2;FRS3;DOK1 |
| insulin receptor substrate binding | GRB2;INSR;INSRR;PIK3CB;PRKCZ;INSRA;PRKCD;PIK3CA;JAK2 |
| non-membrane spanning protein tyrosine phosphatase activity | ACP1;PTPN18;PTPN9;PTPN12;DUSP1;PTPN4;PTPN11 |
| peptide hormone receptor binding | ADCYAP1;PTHLHA;PTH;NPPA;FYN;NPPC;JAK2;PTPN11;RUNDC3A |
| phospholipase binding | APOC2;SELE;CALM1;PRKCZ;LMNB1;DGKQ;CALM;PTPN11;ARHGAP6 |
| phosphoprotein phosphatase activity | PTPRQ;PTPN2A;CTDSPL2A;PTEN;SSH1;PPP1CBL;ACP2;PPP4CB;PTPRK |
| protein binding | GPS2;GNA14;ADAM10;PCGF3;UBA6;ODF1;PDZD11;DZIP1L;EIF5A |
| protein domain specific binding | HIST4H4;ARRB2;TBL1X;SHC4;CHMP2A;TNFAIP1;ZNF521;SHROOM2;HIST1H4L |
| protein tyrosine phosphatase activity | DUSP8A;DUSP19;DUPD1;PTPRK;EYA2;CDC14AB;MTMR6;DNAJC6;CDC14C |
| receptor tyrosine kinase binding | PIK3R2;Flt3l;FIZ1;DOCK4;PCNA;SHC4;FNTA;TOB1;ANGPT2A |
PTPN11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN11 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN11.
GAB1
Research Area
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Customer Reviews (3)
Write a reviewTheir technical expertise and knowledge of the PTPN11 protein are invaluable resources.
This reliability reduces experimental variability and enhances the accuracy of data interpretation.
the manufacturer's commitment to continuous innovation and development of new tools and technologies ensures that I have access to the latest advancements in PTPN11 protein research.
Q&As (5)
Ask a questionYes, genetic testing can identify mutations in the PTPN11 gene, providing valuable information for diagnosis and treatment planning.
PTPN11 is involved in various signaling pathways, including the RAS-MAPK pathway, and its mutations can dysregulate these pathways, leading to abnormal cell signaling.
Yes, PTPN11 plays a crucial role in normal cellular functions by regulating the activity of proteins through dephosphorylation.
Yes, the presence of PTPN11 mutations can serve as a biomarker for specific cancers and developmental disorders.
Mutations in PTPN11 can lead to developmental disorders, including Noonan syndrome and LEOPARD syndrome, affecting growth and development.
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