PTPN22
-
Official Full Name
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PTPN22 Related Articles
PTPN22 involved in several pathways and played different roles in them. We selected most pathways PTPN22 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
PTPN22 has several biochemical functions, for example, SH3 domain binding, kinase binding, phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN22 itself. We selected most functions PTPN22 had, and list some proteins which have the same functions with PTPN22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | SH3BGRL;PLSCR1;GRB2;ARHGAP1;CD2AP;ELMO2;PARK2;ARHGAP31;MAPT |
| kinase binding | PIP5K1A;JAKMIP1;HAP1;STRADA;RB1;UBQLN1;MIDN;C2orf44;ATF5 |
| phosphatase activity | PTPN22;SACM1L;PTP4A2A;C12orf5;PPP1CC;PTPN4A;DUSP10;PTPRU;PTPRUB |
| protein binding | ARF4;NUDT22;SMN1;GEMIN8;MON2;RIPK3;UBE2Z;RAD51L3;GJA4 |
| protein tyrosine phosphatase activity | PTPN6;UBASH3B;EYA3;MTMR4;RNGTT;PTPRF;PTPRO;DUSP7;DUSP23B |
| ubiquitin protein ligase binding | CCDC50;UBE2S;RAD18;BAG4;XRCC5;WASH;RNF40;PER1;HM13 |
PTPN22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN22 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN22.
LCK; CD247; SKAP2; ZAP70; PSTPIP1
- Q&As
- Reviews
Q&As (7)
Ask a questionThe rs2476601 SNP in PTPN22 is associated with an increased risk of Type 1 Diabetes (T1D) and other autoimmune diseases.
Controversy exists over whether the minor allele of rs2476601 enhances or reduces PTPN22 function in TCR signaling, leading to conflicting conclusions in different studies.
The effect of the minor allele of rs2476601 on PTPN22 function in TCR signaling is controversial, with conflicting reports suggesting both enhanced and reduced function.
PTPN22's function has been studied in monocytes, macrophages, dendritic cells, and neutrophils, revealing insights beyond TCR and BCR signaling.
The primary function of the PTPN22 protein is to regulate a variety of leukocyte signaling pathways in immune cells.
Autoimmunity-associated variants of PTPN22 can influence its core function in immune cells, potentially contributing to dysregulated immune responses.
Unresolved questions in the review highlight areas that require clarification, providing avenues for further research into the role of PTPN22 in immune cell function.
Customer Reviews (3)
Write a reviewPositive changes implemented by the manufacturer based on user input reflected a customer-centric approach.
The compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.
We appreciated the straightforward incorporation of the product into our laboratory's instrumentation and automation systems.
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