ptpn6
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  • Official Full Name
  • protein tyrosine phosphatase, non-receptor type 6
  • Background
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PTPN6; protein tyrosine phosphatase, non-receptor type 6; HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1; tyrosine-protein phosphatase non-receptor type 6; hematopoietic cell phosphatase; protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP-1; hematopoietic cell protein-tyrosine phosphatase;
Cat.#:PTPN6-3129HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTPN6 Protein, MYC/DDK-tagged
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Cat.#:PTPN6-222HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN6 protein, His-tagged
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Cat.#:PTPN6-289HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN6 protein, His-tagged
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Cat.#:PTPN6-31401THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN6
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Cat.#:Ptpn6-8685MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Ptpn6, His-GST tagged
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Cat.#:PTPN6-4835RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTPN6 Protein
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Cat.#:PTPN6-3131CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTPN6
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Cat.#:PTPN6-10326ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PTPN6
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Cat.#:PTPN6-1520HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN6 (Active), GST-tagged
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Cat.#:PTPN6-465HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN6,GST-tagged,Active
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Cat.#:PTPN6-71HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Protein Tyrosine Phosphatase, Non-receptor Type 6
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Cat.#:PTPN6-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse PTPN6 cell lysate
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Involved Pathway

PTPN6 involved in several pathways and played different roles in them. We selected most pathways PTPN6 participated on our site, such as Adherens junction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adherens junction
CDC42L; PTBP3; INSRB; INSRA; WASLB; CTNND1; RAC3B; CTNNA3; CSNK2B; SMAD3
Jak-STAT signaling pathway
IL9; PRL2; IFNAR1; LEP; IL12B; SOCS4; IL2RGA; Il23a; Il12b; TYK2; IRX1
Natural killer cell mediated cytotoxicity
RAC2; CD244; KIR2DS4; SHC1; TYROBP; Ifna15; RAET1L; NFATC1; KLRC3; BID
T cell receptor signaling pathway
MAP2K7; CD3G; CARD11; GRAPA; AKT2; LCP2; TNF; MAP2K2; PDPK1; GRAP2
B cell receptor signaling pathway
PILRB; Cd79a, Cd79b; CARD11; PPP3CA; ITK; NEDD9; AKT2; TTC6; CMTM3; IKBKB
Leishmaniasis
HLA-DOB; IL4; FCGR1; ITGA4; HLA-DMB; H2-AA; HLA-DRB1; PTPN6; FCGR3A; TGFB3
Proteoglycans in cancer
FLNC; PTCH1; TNF; WNT7B; TRP53; ANK1; VAV2; CD44; ITGAV; SLC9A1

Protein Function

PTPN6 has several biochemical functions, for example, protein binding, protein kinase binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN6 itself. We selected most functions PTPN6 had, and list some proteins which have the same functions with PTPN6. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein ATPAF2; TRAF3IP2; CRB1; RGS6; CDKN2C; GET4; DHX16; SART3; TCTN2; RPRD1A
Function protein kinase binding
Related Protein CCNL2; KCNA5; SUFU; RHOD; PLCG1; PEBP1; RPS6; NBEA; TSACC; NCS1
Function protein tyrosine phosphatase activity
Related Protein DUSP6; CDC25D; DNAJC6; LRP8; CDC14AB; MTMR7; CDC14AA; KIAA1274; PTPN4A; MTMR14
Function transmembrane receptor protein tyrosine phosphatase activity
Related Protein PTPN6; PTPRF; PTPRD; PTPRG; PTPRM; PTPRN2; EVLA; PTPRE; PTPRO; PTPRS

Interacting Protein

PTPN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN6.
KIR2DL3; EPOR

PTPN6 Related Articles

Li, YF; Xu, SL; et al. Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool. NATURE COMMUNICATIONS 5:-(2014).
Youssef, G; Gillett, C; et al. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: A potential novel prognostic marker for breast cancer. MODERN PATHOLOGY 27:361-374(2014).