Recombinant Human RGS10, His-tagged

• Cat.No.: RGS10-30741TH
• Product Overview: Recombinant full length Human RGS10, Isoform 3 with an N terminal His tag; 205 amino acids with the tag; mwt: 23.7kDa.

Specification

• Description: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
• Protein length: 181 amino acids
• Conjugation: HIS
• Molecular Weight: 23.700kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSHNVLFWLACED FKKMQDKTQM QEKAKEIYMT FLSSKASSQV NVEGQSRLNE KILEEPHPLM FQKLQDQIFN LMKYDSYSRF LKSDLFLKHK RTEEEEEDLP DAQTAAKRAS RIYNT
• Sequence Similarities: Contains 1 RGS domain.

Gene Information

• Gene Name: RGS10 regulator of G-protein signaling 10 [ Homo sapiens ]
• Official Symbol: RGS10
• Synonyms: RGS10; regulator of G-protein signaling 10; regulator of G protein signalling 10
• Gene ID: 6001
• mRNA Refseq: NM_001005339
• Protein Refseq: NP_001005339
• MIM: 602856
• Uniprot ID: O43665
• Chromosome Location: 10q25
• Pathway: Calcium Regulation in the Cardiac Cell, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Signal Transduction, organism-specific biosystem
• Function: GTPase activator activity; signal transducer activity