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RGS20

Official Full Name

regulator of G-protein signaling 20
Overview

The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms

RGS20; regulator of G-protein signaling 20; regulator of G protein signalling 20; RGSZ1; ZGAP1; G(z)GAP; Gz selective GTPase activating protein; HGNC:14600; Regulator of G protein signaling 20; Regulator of Gz selective protein signaling 1; gz-GAP; OTTHUMP00000227381; OTTHUMP00000227383; OTTHUMP00000227397; regulator of G-protein signaling Z1; regulator of G-protein signalling 20; gz-selective GTPase-activating protein; regulator of Gz-selective protein s;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RGS20-2279H	Recombinant Human RGS20, His-tagged	E.coli	His	C-term-234aa	$319 / 25ug
Human	RGS20-2377HCL	Recombinant Human RGS20 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RGS20-3428H	Recombinant Human RGS20 protein, GST-tagged	E.coli	GST	1-234aa	Inquiry
Human	RGS20-2654H	Recombinant Human RGS20 Protein, His-tagged	E.coli	N-His	Met1-Ala388	Inquiry
Mouse	Rgs20-5497M	Recombinant Mouse Rgs20 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	RGS20-565Z	Recombinant Zebrafish RGS20	Mammalian Cell	His		Inquiry
Chicken	RGS20-6405C	Recombinant Chicken RGS20	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RGS20 Related Articles

RGS20 involved in several pathways and played different roles in them. We selected most pathways RGS20 participated on our site, such as Calcium Regulation in the Cardiac Cell, G alpha (i) signalling events, G alpha (z) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium Regulation in the Cardiac Cell	RGS16;CX30.3;RGS19;CX27.5;GJA10;GJA3;KCNJ5;GJB2;ADRA1D
G alpha (i) signalling events	OPN1MW;NMUR1;ANXA1;PENKB;GPR18;DRD3;SSTR1;OXER1;CXCR7B
G alpha (z) signalling events	ADRA2A;ADRA2C;RGS4;RGS19;RGS20;ADRA2B;RGS17
GPCR downstream signaling	ARHGEF9;SOUL4;ARHGAP4;ADRA2A;GPRC6A;OPN1LW2;CNR2;S1PR3;OPN4
Myometrial Relaxation and Contraction Pathways	GUCA2A;GABPB1;IGFBP2;CNN2;CRH;CNN1;ATF5;IGFBP5;RGS20
Signal Transduction	TNKS2;RBP2A;RGS9BP;DEPDC7;SDR16C5;ARHGAP11A;PCSK6;PYYA;GPR18
Signaling by GPCR	CXCR7B;GPR4;GPR77;RAMP2;TAS2R7;PTHRP2;RGS4;ARHGEF18;XK

RGS20 has several biochemical functions, for example, GTPase activator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS20 itself. We selected most functions RGS20 had, and list some proteins which have the same functions with RGS20. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	AXIN2;ARHGAP28;RABEP1;PLEKHG6;RGS14A;ARHGAP42A;ARHGAP4A;RGS7;DOCK2
protein binding	XIAP;IKBKE;HIST2H4;SAMM50;CCT4;TCEB2;SOX9;SNCAIP;SLC9A1

RGS20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS20 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS20.

GLRX3; OTX1; CATSPER1; MTNR1A; Hoxa1

Walther, S; Strittmatter, F; et al. Expression and Alpha1-adrenoceptor Regulation of Caldesmon in Human Prostate Smooth Muscle. UROLOGY 79:-(2012).

Rivero, G; Gabilondo, AM; et al. Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain. NEUROCHEMISTRY INTERNATIONAL 57:722-729(2010).