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RGS18

Official Full Name

regulator of G-protein signaling 18
Overview

This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms

RGS18; regulator of G-protein signaling 18; regulator of G protein signalling 18; RGS13; Regulator of G protein signalling 13; RGS 18; RGS18_HUMAN; regulator of G-protein signalling 13; regulator of G-protein signalling 18;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RGS18-2277H	Recombinant Human RGS18, GST-tagged	E.coli	GST	1-235aa	$319 / 25ug
Human	RGS18-2381HCL	Recombinant Human RGS18 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RGS18-301373H	Recombinant Human RGS18 protein, GST-tagged	E.coli	GST	Met1-Leu235	Inquiry
Human	RGS18-1183H	Recombinant Human RGS18 Protein, His-tagged	E.coli	His		Inquiry
Rat	RGS18-5016R	Recombinant Rat RGS18 Protein	Mammalian Cell	His		Inquiry
Rat	RGS18-4675R	Recombinant Rat RGS18 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	RGS18-4675R-B	Recombinant Rat RGS18 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	RGS18-4673Z	Recombinant Zebrafish RGS18	Mammalian Cell	His		Inquiry
Chicken	RGS18-4625C	Recombinant Chicken RGS18	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RGS18 Related Articles

RGS18 involved in several pathways and played different roles in them. We selected most pathways RGS18 participated on our site, such as Calcium Regulation in the Cardiac Cell, G alpha (i) signalling events, G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium Regulation in the Cardiac Cell	PKIB;CHRM3;GJB6;RGS19;RGS10;GJB3;RGS18;PKIG;ADRA1D
G alpha (i) signalling events	NMUR1;CCL35.1;CCR3;RGR;CHRM2;PENKB;CHRM4;ANXA1A;CXCL11.8
G alpha (q) signalling events	FPR-RS4;CYSLTR1;NTS;ARHGEF25;CHRM1;TAC3;EDNRA;MGLL;TAC2
GPCR downstream signaling	OPN1LW;CCL27;FGD4;GPR55A;FPR-RS3;GPR4;ARHGEF1A;CCR9;CCR6
Gastrin-CREB signalling pathway via PKC and MAPK	GPR132;TRPC6A;PROKR2;UTS2D;FFAR3;RGS19;CCK;PROK1;TAC3
Myometrial Relaxation and Contraction Pathways	ACTA1;RGS6;RGS11;CNN1;CRHR1;ADM;RGS10;RGS17;IGFBP6
Signal Transduction	TLE4;ARHGAP24;NCKIPSD;WDR19;DZIP1;RGS9BP;HCRT;CDC42EP1B;VIP2
Signaling by GPCR	EMR2;TRH;UTS2;PTH;CRHB;ADM2;OXGR1A.1;TAC3;OPN5

RGS18 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS18 itself. We selected most functions RGS18 had, and list some proteins which have the same functions with RGS18. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	ASAP2;PREX2;DOCK1;SIPA1L1;CHN2;DEPDC1A;TSC2;RGS6;GDI1

RGS18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS18 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS18.

Gegenbauer, K; Nagy, Z; et al. Cyclic Nucleotide Dependent Dephosphorylation of Regulator of G-Protein Signaling 18 in Human Platelets. PLOS ONE 8:-(2013).

Iwai, K; Koike, M; et al. RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway. JOURNAL OF BONE AND MINERAL RESEARCH 22:1612-1620(2007).

Doupnik, CA; Xu, T; et al. Profile of RGS expression in single rat atrial myocytes. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1522:97-107(2001).