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RGS6

Official Full Name

regulator of G-protein signaling 6
Overview

This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.
Synonyms

RGS6; regulator of G-protein signaling 6; regulator of G protein signalling 6; DKFZp313G1241; FLJ43552; G protein signaling 6 regulator; GAP; GTPase activating protein; MGC142132; Regulator of G protein signaling 6; RGS 6; S914; H_DJ1108A12.1; WUGSC:H_DJ0283M22.1; WUGSC:H_DJ1108A12.1; regulator of G-protein signalling 6;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
N/A
N
GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RGS6-2370HCL	Recombinant Human RGS6 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RGS6-2016H	Recombinant Human RGS6 Protein, His&GST-tagged	E.coli	N-His&GST	Met1-Glu127	Inquiry
Mouse	RGS6-14147M	Recombinant Mouse RGS6 Protein	Mammalian Cell	His		Inquiry
Mouse	RGS6-7570M	Recombinant Mouse RGS6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	RGS6-7570M-B	Recombinant Mouse RGS6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Rgs6-8188R	Recombinant Rat Rgs6 protein, His & T7-tagged	E.coli	His/T7	Met1~Ser472 (Accession # F1LS67)	Inquiry
Rhesus Macaque	RGS6-3877R	Recombinant Rhesus monkey RGS6 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	RGS6-3694R-B	Recombinant Rhesus Macaque RGS6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	RGS6-3694R	Recombinant Rhesus Macaque RGS6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	RGS6-3469Z	Recombinant Zebrafish RGS6	Mammalian Cell	His		Inquiry
Chicken	RGS6-4318C	Recombinant Chicken RGS6	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

RGS6 involved in several pathways and played different roles in them. We selected most pathways RGS6 participated on our site, such as Calcium Regulation in the Cardiac Cell, G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium Regulation in the Cardiac Cell	GJB6;CX55.5;KCNJ3;GNB5B;YWHAQ;AKR1C1;GJB3;RGS17;GJA3
G alpha (i) signalling events	CCR3;APLNR;RGS4;TAS2R16;SST;AGT;OPN1LW1;PPY;APLN
GPCR downstream signaling	ANXA1C;GHRH;EDN2;NET1;ADORA3;PTHLH;S1PR3;KISS1;CGA
Myometrial Relaxation and Contraction Pathways	RGS14;RGS17;RGS18;RGS16;RGS5;GABPB1;IGFBP2;RGS7;MYLK2
Signal Transduction	ROR2;SPRY1;ARHGAP24;TAX1BP1;GPBAR1;CRABP1A;BCO2L;SOX9A;SOUL4
Signaling by GPCR	RGS4;RGS18;PENKB;PYYA;TAS2R7;RCA2.1;HEBP1;EMR2;RGS21

RGS6 has several biochemical functions, for example, GTPase activator activity, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS6 itself. We selected most functions RGS6 had, and list some proteins which have the same functions with RGS6. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	ARHGAP42;ARFGAP1;GRTP1;TBC1D30;TBCD;ARHGAP4;RAP1GDS1;OPHN1;ARHGAP26
protein binding	LDLRAP1;KIAA0319L;VASNA;FBXO33;JAM2;HFE2;C8orf4;GPAA1;CDX1
signal transducer activity	HCAR1-1;MRGPRB1;RGS9;CXCR4A;GNB1A;OPN1LW2;MRGPRH;GNRHR3;ADRB3B

RGS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS6.

HSP90AB1; PSMD2; HSP90AB1; AARSD1