RGS14

  • Official Full Name

    regulator of G-protein signaling 14
  • Overview

    This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
  • Synonyms

    RGS14;regulator of G-protein signaling 14;regulator of G protein signalling 14;regulator of G-protein signalling 14

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
RGS14-2276H Recombinant Human RGS14, GST-tagged E.coli Human GST 217-566aa
RGS14-14136M Recombinant Mouse RGS14 Protein Mammalian Cells Mouse His
RGS14-5015R Recombinant Rat RGS14 Protein Mammalian Cells Rat His
RGS14-6943H Recombinant Human Regulator Of G-Protein Signaling 14, His-tagged E.coli Human His 1-566aa
RGS14-1502HCL Recombinant Human RGS14 cell lysate Human Non
RGS14-1007H Recombinant Human RGS14 Protein (P2-L566), Tag Free E.coli Human Non P2-L566
RGS14-1008H Recombinant Human RGS14 Protein (P2-L566), His tagged E.coli Human His P2-L566
RGS1427490H Recombinant Human RGS14 (56-207)_RGS domain Protein Human
RGS14-3949H Recombinant Human RGS14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
RGS14-4674R Recombinant Rat RGS14 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
RGS14-4674R-B Recombinant Rat RGS14 Protein Pre-coupled Magnetic Beads HEK293 Rat
Rgs14-5493M Recombinant Mouse Rgs14 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
Rgs14-621M Recombinant Mouse Rgs14 protein, His&Myc-tagged E.coli Mouse His&Myc 1-547aa
RGS14-7564M Recombinant Mouse RGS14 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
RGS14-7564M-B Recombinant Mouse RGS14 Protein Pre-coupled Magnetic Beads HEK293 Mouse
RGS149388H Recombinant Human RGS14 (302-566)_RBD domain Protein Human

    Involved Pathway

    RGS14 involved in several pathways and played different roles in them. We selected most pathways RGS14 participated on our site, such as Calcium Regulation in the Cardiac Cell,G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction RTKN,KEL,PYYA,ARHGAP22,ASH2L,PMEPA1,GPR31,ARHGAP23,TTC21B,CLIP3
    Myometrial Relaxation and Contraction Pathways CRH,CNN1,ATF5,CNN2,PKIG,RGS18,MYLK2,GUCA2B,ACTA1,RGS20
    Rap1 signaling pathway PFN4,EFNA4,LOC608458,CSF1,EFNA2
    GPCR downstream signaling HRH3,GNA13,CALCRL,ADM,GPR55A,SOUL4,VIP,RHOAE,PTHLH,DRD2
    G alpha (i) signalling events SOUL4,GPR55,ADRA2B,PTGDR2,RGS18,RGS1,PENKA,OPN1MW2,SSTR5,AGTR2
    Signaling by GPCR APLN,KEL,OPN1LW2,RGS4,PRLH,OXGR1A.1,CD97,NET1,FGD2,OXTRL
    Calcium Regulation in the Cardiac Cell ANXA6,GNB5B,RGS11,RGS6,CHRM5,CHRM1,RGS18,CX34.4,AKR1C1,ADRB2

    Protein Function

    RGS14 has several biochemical functions, for example, G-protein alpha-subunit binding,GDP-dissociation inhibitor activity,GTPase activating protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS14 itself. We selected most functions RGS14 had, and list some proteins which have the same functions with RGS14. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity ARHGAP26,ARHGAP28,PLCB1,GIT2B,TBC1D24,SGSM3,SOS1,RGS12B,FAM13A,RGS11
    GTPase activating protein binding PLCD1,TSC1,CDH1,PIN1,FMNL1,GNAI3,TUBB,GNAI1,MEX3B,GNAO1
    receptor signaling protein activity ADCYAP1,Siglece,FLRT2,FCAR,TIAM2,KLK1B3,ARAF,FCGR1A,ARF1,TYROBP
    G-protein alpha-subunit binding DRD1A,RIC8A,CRHR1,ARHGEF11,AGTR1A,LPAR1,HTR2B,F2R,IGF1R,RGS19
    microtubule binding MAP2,DPYSL5B,KIF22,PRC1A,TRAF3IP1,NDRG1,TUBGCP5,NDEL1A,KIF1B,KIF16B
    GDP-dissociation inhibitor activity GDI1,RANBP1,GPSM1B,GPSM1,GPSM2L,SH3BP4,ITGB1BP1,SH3BP4A
    protein binding HOMER1,CREB5,CHD,ARHGDIG,ZCCHC10,AMY1A,FHIT,PIN4,C1QTNF1,LCP2
    receptor signaling complex scaffold activity NCK1,CD3G,MMS19,SPAG9A,G3BP2,SPAG9,AXIN1,SHANK1,ROPN1B,CD3E

    Interacting Protein

    RGS14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS14 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS14.

    TINF2;GNAI1;GNAI1;XPO1;GNAI3;NFKB1;WAS;TRAF2;POT1

    Resources

    References

    • Evans, PR; Lee, SE; et al. Postnatal Developmental Expression of Regulator of G Protein Signaling 14 (RGS14) in the Mouse Brain. JOURNAL OF COMPARATIVE NEUROLOGY 522:186-203(2014).

    Ask a Question for All RGS14 Products

    Required fields are marked with *

    My Review for All RGS14 Products

    Required fields are marked with *