| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
53.41 kDa |
| AA Sequence : |
MAGASRLLFLWLGCFCVSLAQGERP KPPFPELRKAVPGDRTAGGGPDSEL QPQDKVSEHMLRLYDRYSTVQAART PGSLEGGSQPWRPRLLREGNTVRSF RAAAAETLERKGLYIFNLTSLTKSE NILSATLYFCIGELGNISLSCPVSG GCSHHAQRKHIQIDLSAWTLKFSRN QSQLLGHLSVDMAKSHRDIMSWLSK DITQFLRKAKENEEFLIGFNITSKG RQLPKRRLPFPEPYILVYANDAAIS EPESVVSSLQGHRNFPTGTVPKWDS HIRAALSIERRKKRSTGVLLPLQNN ELPGAEYQYKKDEVWEERKPYKTLQ AQAPEKSKNKKKQRKGPHRKSQTLQ FDEQTLKKARRKQWIEPRNCARRYL KVDFADIGWSEWIISPKSFDAYYCS GACQFPMPKSLKPSNHATIQSIVRA VGVVPGIPEPCCVPEKMSSLSILFF DENKNVVLKVYPNMTVESCACRTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
