bmp4
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  • Official Full Name
  • bone morphogenetic protein 4
  • Background
  • Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors.
  • Synonyms
  • BMP4; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6; BMP-4; Bone morphogenetic protein 2B; BMP-2B; BMP2B, DVR4; OTTHUMP00000178992
Cat.#:BMP4-02HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein-4
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Cat.#:BMP4-20HTag:N/A
Source (Host):HeLa cellsSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein 4
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Cat.#:BMP4-21HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP4, His-tagged
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Cat.#:BMP4-23HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Bone Morphogenetic Protein 4
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Cat.#:BMP4-213HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP4 protein, His/S-tagged
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Cat.#:BMP4-24HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human BMP4, HIgG1 Fc-tagged, mutant
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Cat.#:BMP4-26171THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP4, His-tagged
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Cat.#:BMP4-261HTag:
Source (Host):HeLaSpecies:Human
Product nameRecombinant Human BMP4 protein
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Cat.#:BMP4-262HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human BMP4 protein, His-tagged
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Cat.#:BMP4-263HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human BMP4 protein, His-tagged
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Cat.#:BMP4-266HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP4 Protein, GST-tagged
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Cat.#:BMP4-569HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP4 protein, His & T7-tagged
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Cat.#:Bmp4-214MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bmp4 protein, His/S-tagged
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Cat.#:BMP4-2432MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BMP4 Protein
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Cat.#:BMP4-267HTag:His/Myc
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse BMP4 Protein, His-MBP-tagged
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Cat.#:Bmp4-578TMTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine BMP4
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Cat.#:Bmp4-583MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse BMP-4
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Cat.#:BMP4-869MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse BMP4 Protein, Fc-tagged
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Cat.#:Bmp4-215RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bmp4 protein, His/S-tagged
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Cat.#:Bmp4-572RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bmp4 protein, His-tagged
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Cat.#:Bmp4-573RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bmp4 protein, His-tagged
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Cat.#:BMP4-568CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken BMP4 protein, His-tagged
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Cat.#:BMP4-574RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit BMP4 protein, His-tagged
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Cat.#:BMP4-575RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit BMP4 protein, His-tagged
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Cat.#:BMP4-6790CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BMP4
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Cat.#:bmp4-809ZTag:Met
Source (Host):E. coliSpecies:Zebrafish
Product nameRecombinant Zebrafish bmp4
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Cat.#:BMP4-570PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig BMP4 protein, His-tagged
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Cat.#:BMP4-571PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig BMP4 protein, His & GST-tagged
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Cat.#:BMP4-06HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP4
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Cat.#:BMP4-8431HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BMP4 293 Cell Lysate
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Cat.#:BMP4-8432HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BMP4 293 Cell Lysate
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Cat.#:BMP4-135HGTag:
Source (Host):NS0Species:Human
Product nameGMP Recombinant Human BMP4 Protein
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Cat.#:CSC-P0548Tag:
Source (Host):Species:Human
Product nameAnti-Human BMP4 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0549Tag:
Source (Host):Species:Human
Product nameAnti-Human BMP4 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0550Tag:
Source (Host):Species:Human
Product nameAnti-Human BMP4 scFv Stable Cell Line-CHO
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Involved Pathway

BMP4 involved in several pathways and played different roles in them. We selected most pathways BMP4 participated on our site, such as Hedgehog signaling pathway, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hedgehog signaling pathway
CSNK1G3; WNT11B; PRKACAB; PRKACB; WNT5B; WNT11R; LRP2; SKIA; Shh; PRKACA
TGF-beta signaling pathway
GDF6A; NOG; SMAD3A; ID4; BMPR1BA; SMAD9; MAPK3; TGFBR1; TGFB1; SPAW
Hippo signaling pathway
TEAD1; WNT4; FZD5; NF2; PPP2R1A; PRKCI; TP73; WWTR1; SERPINE1; WTIP
Signaling pathways regulating pluripotency of stem cells
PIK3CD; ID4; AKT1; WNT9B; FZD6; BMP4; HOXB1; FZD1; LIF; ID2
Thyroid hormone signaling pathway
THRB; ATP1B4; KRAS; TBC1D4; TRP53; CCND1; KAT2B; HIF1A; EP300; HDAC2
Pathways in cancer
FGF4; AGTR1A; FGF12; TCF7; AXIN2; BAX; BMP4; ROCK2; PDGFA; EGLN3
Basal cell carcinoma
PTCH1; WNT7B; WNT4; TP53; STK36; FZD6; TCF7; DVL2; WNT8B; APC2

Protein Function

BMP4 has several biochemical functions, for example, BMP receptor binding, chemoattractant activity, co-receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP4 itself. We selected most functions BMP4 had, and list some proteins which have the same functions with BMP4. You can find most of the proteins on our site.
Function
Related Protein
Function BMP receptor binding
Related Protein BMP6; BMP7; BMP5; BMP7A; BMP2B; BMP3; BMP7B; BMP8A; PYCARD; BMP8B
Function chemoattractant activity
Related Protein CCL15; VEGFB; SAA4; FGF7; FGF8; VEGFC; FGF10; BMP4; NTF3; LGALS3
Function co-receptor binding
Related Protein NEO1; HFE; TFR2; BMP4; DKK1; BMP2
Function cytokine activity
Related Protein IL5; WNT2; HMGB1; SPAW; TNFSF15; IL36G; IL15; Cxcl15; IL17B; GDF2
Function growth factor activity
Related Protein FGF12; GDNF; FGF20; MSTN; TGFA; FGF12A; MDKA; HBEGF; GDF10B; PDGFB
Function heparin binding
Related Protein FGF10; RPL29; HDGF; FGF1; F11; PTCH1; FBLN7; ZNF146; ABP1; SERPINA5
Function protein binding
Related Protein NOV; CLNK; TACC1; MAPRE2; IL17RE; ZNF317; Fert2; VPS53; PAGE2; PCGF5
Function protein homodimerization activity
Related Protein LSM1; PVRL1A; SLC14A2; HIF1AN; TPD52; SFTPC; GDNFA; SUPV3L1; TKT; CHEK2
Function transforming growth factor beta receptor binding
Related Protein GDF3; GDF9; BMP5; INHBC; LFT1; SPAW; GDF11; GDF10; INHA; SMAD2

Interacting Protein

BMP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP4.
BMPR1A; FSTL1; WFIKKN2; WFIKKN1; olfml3; chrd; ZFYVE9; C12orf60

BMP4 Related Articles

Arany, PR; Huang, GX; et al. Multi-lineage MSC Differentiation via Engineered Morphogen Fields. JOURNAL OF DENTAL RESEARCH 93:1250-1257(2014).
Siddique, I; Curran, SP; et al. Gremlin Promotes Peritoneal Membrane Injury in an Experimental Mouse Model and Is Associated with Increased Solute Transport in Peritoneal Dialysis Patients. AMERICAN JOURNAL OF PATHOLOGY 184:2976-2984(2014).

BMP4 Related Gene Family

TGF