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BMP4

  • Official Full Name

    bone morphogenetic protein 4

  • Overview

    Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors.
  • Synonyms

    BMP4; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6; BMP-4; Bone morphogenetic protein 2B; BMP-2B; BMP2B, DVR4; OTTHUMP00000178992;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Zebrafish
  • CHO-K1
  • E.coli
  • HEK293
  • HeLa
  • Human cells
  • Mammalian Cell
  • Mammalian cells
  • Mouse myeloma cell line
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • Myc
  • His|GST
  • His|Myc
  • His|S
  • His|T7
  • SUMO
  • Met
  • N/A
  • N
  • rFc
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BMP4-06H Active Recombinant Human BMP4 E.coli N/A
Human BMP4-01HG Active GMP Recombinant Human BMP-4 Protein CHO-K1
Human BMP4-10H Active Recombinant Human BMP4 Protein(Ser293-Arg408, E399D) E.coli N/A Ser293-Arg408, E399D
Human BMP4-26171TH Recombinant Human BMP4, His-tagged E.coli His
Human BMP4-24H Recombinant Human BMP4 Protein, Ser293-Arg408 Mouse myeloma cell line Ser293-Arg408
Human BMP4-21H Recombinant Human BMP4, His-tagged E.coli His
Human BMP4-23H Recombinant Human Bone Morphogenetic Protein 4 HEK293 N/A
Human BMP4-569H Recombinant Human BMP4 protein, His & T7-tagged E.coli His/T7 Ser22~Arg408 (Accession # P12644
Human BMP4-20H Recombinant Human Bone Morphogenetic Protein 4 HeLa N/A
Human BMP4-261H Recombinant Human BMP4 protein HeLa N/A
Human BMP4-263H Recombinant Human BMP4 protein, His-tagged E.coli His
Human BMP4-02H Recombinant Human BMP4 protein E.coli N/A 117
Human BMP4-213H Recombinant Human BMP4 protein, His/S-tagged E.coli His/S
Human BMP4-262H Recombinant Human BMP4 protein, His-tagged E.coli His
Human BMP4-266H Recombinant Human BMP4 Protein, GST-tagged E.coli GST
Human BMP4-8432HCL Recombinant Human BMP4 293 Cell Lysate HEK293 N/A
Human BMP4-8431HCL Recombinant Human BMP4 293 Cell Lysate HEK293 N/A
Human BMP4-26HG Recombinant Human BMP4 Protein, GMP Grade, Animal-Free E.coli
Human BMP4-001H Recombinant Human BMP4 Protein, His-MBP-tagged E.coli His/Myc
Human BMP4-013H Active Recombinant Human BMP4 Protein E.coli
Human BMP4-4364H Recombinant Human BMP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BMP4-4364H-B Recombinant Human BMP4 Protein Pre-coupled Magnetic Beads HEK293
Human BMP4-2600H Recombinant Human BMP4 protein, His-SUMO-tagged E.coli His-SUMO 293-408aa
Human BMP4-135HG Active GMP Recombinant Human BMP4 Protein Mammalian cells N/A
Human BMP4-321H Recombinant Human BMP4 Protein, His-tagged E.coli N-His Ser22-Arg408
Human BMP4-0772H Recombinant Human BMP4 Protein (Ala24-Arg408), N-His tagged E.coli N-His Ala24-Arg408
Human BMP4-35HG Active Recombinant Human BMP4 Protein (Lys303-Arg408), GMP Grade, Animal-Free E.coli Lys303-Arg408
Human BMP4-13H Recombinant Active Human BMP4 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human BMP4-1325HG Active GMP Recombinant Human BMP4 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human BMP-4(NP_001334841.1 ) was expressed with Fc tag at the C-terminal.
Human BMP4-04H Active Recombinant Human BMP4 Protein, Animal Free Human cells
Human BMP4-03H Recombinant Human BMP4 Protein E.coli 117 aa
Human BMP4-1164HFL Recombinant Full Length Human BMP4 Protein, C-His-tagged E.coli His
Human BMP4-11H Active Recombinant Human BMP4 Protein, Pre-aliquoted E.coli Ala18-Glu144
Human BMP4-402H Recombinant Human BMP4 Protein E.coli Tag Free
Human BMP4-279H Active Recombinant Human BMP4 Protein (Lys303-Arg408), C-His tagged, Animal-free, Carrier-free E.coli C-His Lys303-Arg408
Mouse Bmp4-583M Active Recombinant Mouse BMP-4 E.coli N/A
Mouse BMP4-267H Active Recombinant Mouse BMP4 Protein, His-MBP-tagged E.coli His/Myc
Mouse Bmp4-01M Active Recombinant Mouse Bmp4 Protein, His-Tagged E.coli His
Mouse Bmp4-578TM Recombinant Murine BMP4 E.coli N/A
Mouse BMP4-869M Recombinant Mouse BMP4 protein, rFc-tagged HEK293 rFc Ser293-Arg408
Mouse BMP4-2432M Recombinant Mouse BMP4 Protein Mammalian Cell His
Mouse Bmp4-214M Recombinant Mouse Bmp4 protein, His/S-tagged E.coli His/S
Mouse Bmp4-14M Recombinant Active Mouse BMP4 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Bmp4-324M Recombinant Mouse Bmp4 Protein, His-tagged E.coli N-His Ser22-Arg408
Mouse Bmp4-024MG Active GMP Recombinant Mouse Bmp4 protein, Fc-tagged HEK293 Fc DNA sequence encoding Mouse BMP-4(NCBI Reference Sequence: NP_031580.2) was expressed with Fc tag at the C-terminal.
Mouse Bmp4-15M Active Recombinant Mouse Bmp4 Protein (Lys303-Arg408), C-His tagged, Animal-free, Carrier-free E.coli C-His Lys303-Arg408
Mouse Bmp4-323M Recombinant Mouse Bmp4 Protein, His-tagged E.coli N-His Asn209-Val392
Mouse Bmp4-036M Active Recombinant Mouse Bmp4 Protein E.coli
Mouse BMP4-1054M Recombinant Mouse BMP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BMP4-1054M-B Recombinant Mouse BMP4 Protein Pre-coupled Magnetic Beads HEK293
Rat Bmp4-573R Recombinant Rat Bmp4 protein, His-tagged E.coli His Asn209~Val392
Rat Bmp4-572R Recombinant Rat Bmp4 protein, His-tagged E.coli His Pro28~Glu183 (Accession # Q06826)
Rat Bmp4-215R Recombinant Rat Bmp4 protein, His/S-tagged E.coli His/S
Rabbit BMP4-575R Recombinant Rabbit BMP4 protein, His-tagged E.coli His Thr211~Lys392 (Accession # O46576)
Rabbit BMP4-574R Recombinant Rabbit BMP4 protein, His-tagged E.coli His His23~Arg204
Bovine BMP4-1169B Recombinant Bovine BMP4 protein, GST-tagged E.coli GST 294-409aa
Porcine BMP4-01P GMP Recombinant Porcine BMP4 Protein, His-Tagged E.coli His
Zebrafish bmp4-809Z Active Recombinant Zebrafish bmp4 E.coli Met Ser288-Arg400
Zebrafish bmp4-322Z Recombinant Zebrafish bmp4 Protein, His-tagged E.coli N-His Ser25-Arg400
Pig BMP4-570P Recombinant Pig BMP4 protein, His-tagged E.coli His Arg227~Cys408 (Accession # A7LJT9)
Pig BMP4-571P Recombinant Pig BMP4 protein, His & GST-tagged E.coli His/GST Ser25~Leu201 (Accession # A7LJT9)
Pig BMP4-02P Recombinant Pig BMP4 Protein (Arg227-Cys408), C-His tagged, Animal-free, Carrier-free E.coli C-His Arg227-Cys408
Chicken BMP4-568C Recombinant Chicken BMP4 protein, His-tagged E.coli His Ala244~Lys388 (Accession # Q90752)
Chicken BMP4-6790C Recombinant Chicken BMP4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

BMP4 involved in several pathways and played different roles in them. We selected most pathways BMP4 participated on our site, such as Hedgehog signaling pathway, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hedgehog signaling pathwayGLI2A;WNT1;PRKACG;SAP18;GSK3B;SHHA;WNT2B;WNT9B;LRP2
TGF-beta signaling pathwaySMAD3A;TFDP1;INHBB;BMP2B;ACVR1BA;BMPR2B;EP300;LFT2;RBL1
Hippo signaling pathwayWNT7A;FZD8;WNT2;NF2;GDF7;STK3;FBXW11;TGFBR1;ID2
Signaling pathways regulating pluripotency of stem cellsID1;INHBB;LIF;ACVR2B;IGF1;PIK3CD;KRAS;PCGF1;WNT8A
Thyroid hormone signaling pathwayPRKACG;MTOR;NCOA1;HDAC2;HIF1A;SIN3A;RXRG;TSC2;FXYD2
Pathways in cancerCYCS;AGTR1A;TRAF6;CKS2;CCDC6;VEGFB;SMAD3;PTCH2;PLD1
Basal cell carcinomaFZD6;DVL3;TP53;FZD2;WNT6;GLI1;WNT5A;WNT16;WNT10B

BMP4 has several biochemical functions, for example, BMP receptor binding, chemoattractant activity, co-receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP4 itself. We selected most functions BMP4 had, and list some proteins which have the same functions with BMP4. You can find most of the proteins on our site.

Function Related Protein
BMP receptor bindingBMP6;BMP5;BMP8B;BMP2B;BMP7A;PYCARD;BMP4;BMP7B;BMP8A
chemoattractant activityFGF7;CCL15;CXCL12A;PDGFB;NTF3;VEGFA;MIF;CCL16;VHL
co-receptor bindingNEO1;DKK1;TFR2;HFE;BMP4;BMP2
cytokine activityLFT1;IFNA4;INHBB;GREM2;Cxcl15;IL1RN;IL1F10;GDF5;IL17F
growth factor activityFGF3;GMFB;AREG;FGF4;FGF12A;GDNFA;EPGN;THPO;GPI1
heparin bindingWISP1B;COL20A1;ADAMTS1;THBS1;ITGAM;MPO;HRG;FGFR4;GM4980
protein bindingFBP1;HERC5;CCDC24;NFE2;ARL4C;TAGLN;CLIC1;CFL2;SCN5A
protein homodimerization activityGSTM7;MGLL;CPNE1;SNX9;PGCP;QPRT;IRF3;OSTA;BCL2A1
transforming growth factor beta receptor bindingBMP8B;INHBA;BMP8A;TGFBRAP1;BMP3;GDF5;GDF3;GDF6;MSTNA

BMP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP4.

BMPR1A; FSTL1; WFIKKN2; WFIKKN1; olfml3; chrd; ZFYVE9; C12orf60

Gene Family

TGF

Research Area

Related articles

Arany, PR; Huang, GX; et al. Multi-lineage MSC Differentiation via Engineered Morphogen Fields. JOURNAL OF DENTAL RESEARCH 93:1250-1257(2014).
Siddique, I; Curran, SP; et al. Gremlin Promotes Peritoneal Membrane Injury in an Experimental Mouse Model and Is Associated with Increased Solute Transport in Peritoneal Dialysis Patients. AMERICAN JOURNAL OF PATHOLOGY 184:2976-2984(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is BMP4 applied in spinal fusion surgery? 03/30/2022

BMP4 can be used in spinal fusion surgery to stimulate bone growth and fuse vertebrae together, which can alleviate back pain and stabilize the spine.

Are there any genetic disorders related to BMP4? 07/03/2020

Mutations in BMP4 or its receptors can lead to congenital disorders, such as orofacial clefts and heart defects.

Are there ongoing clinical trials involving BMP4 in regenerative medicine? 07/12/2019

Yes, there are ongoing trials exploring the use of BMP4 in regenerative medicine for conditions like osteoarthritis and tendon injuries.

Are there any potential risks or side effects associated with the clinical use of BMP4? 06/11/2018

Yes, some risks include excessive bone growth, swelling, and inflammation at the application site. These complications can be carefully managed by healthcare providers.

Can BMP4 be used in cosmetic surgery? 02/10/2017

Yes, BMP4 can be used to aid in tissue regeneration in cosmetic procedures, such as in the reconstruction of facial bone defects or enhancement of soft tissue volume.

Customer Reviews (3)

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Reviews
11/22/2020

    The BMP4 protein is a valuable resource for researchers due to its high quality and its ability to meet specific experimental needs.

    08/26/2020

      the manufacturer's technical support team can offer prompt assistance in case any issues arise during the handling or application of the BMP4 protein.

      06/05/2018

        The manufacturer's support can play a crucial role in assisting researchers throughout their trials.

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