BMP8B
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Official Full Name
bone morphogenetic protein 8b
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Overview
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. -
Synonyms
BMP8B; bone morphogenetic protein 8b; BMP8, bone morphogenetic protein 8 (osteogenic protein 2); OP 2; osteogenic protein 2; BMP-8; BMP-8B; BMP8B_HUMAN; Bone morphogenetic protein 8; OP-2; OP2; OTTHUMP00000010836; bone morphogenetic protein 8 (osteogenic protein 2); dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)); BMP8;
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- His
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- His|SUMO
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What is bmp8b protein?
BMPs are a group of signaling molecules that play important roles in bone formation and many other developmental processes. They signal through BMP receptors. BMP8B is classified in the BMP8 subfamily, along with BMP8A. BMP8A and BMP8B are closely related and their genes are located next to each other.
In mice, BMP8B is expressed early in development in the extraembryonic ectoderm, which signals to the proximal epiblast to induce primordial germ cell formation. As shown in this study, BMP8B is required for normal PGC generation. BMP8B also plays roles later in male germ cell development and spermatogenesis. Mice lacking functional BMP8B show defects in initiating and maintaining spermatogenesis.
The protein functions by binding to BMP receptors on target cells and activating intracellular SMAD signaling pathways, which regulate the expression of genes involved in cell differentiation and other processes.
What is the function of bmp8b protein?
Induction of primordial germ cell (PGC) formation: BMP8B is expressed in the extraembryonic ectoderm during early embryogenesis. It signals to proximal epiblast cells adjacent to the extraembryonic ectoderm to induce their specification into PGCs.
Requirement for normal PGC generation: Mice lacking functional BMP8B show severe reduction or absence of PGCs, indicating BMP8B is essential for proper PGC formation.
Role in extraembryonic mesoderm development: BMP8B knockout embryos show defects in allantois development, such as delayed initiation and shorter length. This suggests BMP8B also influences formation of extraembryonic tissues derived from mesoderm.
Bmp8b related signaling pathway
BMP8B signals by binding to type I and type II serine/threonine kinase receptors on the surface of target cells. The major receptors it signals through are: BMPR1A (also known as ALK3), BMPR1B (also known as ALK6), BMPR2.
When BMP8B binds these receptors, it induces phosphorylation of receptor-regulated SMAD (R-SMAD) proteins, specifically SMAD1, SMAD5, and SMAD8.
The phosphorylated R-SMADs then form a complex with the co-SMAD (SMAD4). This activated R-SMAD/co-SMAD complex translocates to the nucleus.
In the nucleus, the SMAD complex associates with other transcription factors to regulate the expression of target genes involved in various signaling responses, such as cell differentiation, proliferation and apoptosis.
Some of the key target genes of the BMP8B-SMAD pathway include ID proteins (inhibitors of differentiation), MSX proteins, and components of the Wnt signaling pathway like Lef1.
BMP8B Related Diseases
- Infertility in males: BMP8B knockout mice show defects in spermatogenesis and infertility. In humans, mutations in BMP8B have been linked to azoospermia (lack of sperm in semen) and oligospermia (low sperm count).
- Hypospadias: A congenital defect where the opening of the urethra is on the underside of the penis instead of at the tip. BMP8B mutations may cause hypospadias in rare cases.
- Cancer: Aberrant BMP signaling, including from BMP8B, has been implicated in certain cancers like prostate, breast and lung cancer. BMP8B expression levels can influence tumor growth and metastasis.
- Skeletal malformations: As BMPs regulate bone development, some skeletal abnormalities have been tied to BMP8B mutations, though rare. Conditions like acrocephalosyndactyly have been linked to BMP8B defects.
- Fertility treatment - Recombinant BMP8B protein could help treat male infertility caused by low BMP8B levels. It may promote spermatogenesis.
- Tissue engineering - BMP8B plays roles in bone formation. It could be used to help engineer bone grafts or stimulate bone/cartilage regeneration.
- Wound healing - Like other BMPs, BMP8B may aid healing of problematic wounds or burns by promoting cell growth and angiogenesis.
- Fertility treatment - Recombinant BMP8B protein could help treat male infertility caused by low BMP8B levels. It may promote spermatogenesis.
- Tissue engineering - BMP8B plays roles in bone formation. It could be used to help engineer bone grafts or stimulate bone/cartilage regeneration.
- Wound healing - Like other BMPs, BMP8B may aid healing of problematic wounds or burns by promoting cell growth and angiogenesis.
High Purity
Fig1. SDS-PAGE (Cat. No.: BMP8B-283H)
High Bioactivity & Detection Sensitivity
Fig2. Measure by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is < 21.8 ng/mL.
( Amy Marble, 2000)
Fig3. PGC numbers at the headfold stage were expressed as means with SEs. The number in parentheses is the number of embryos in each group. * Indicates significant difference of the Bmp8b homozygotes compared with wild-type (P < 0.001) and Bmp8b heterozygote groups (P < 0.001).
(Andrew J. Whittle, 2012)
Fig4. BAT expression of BMPs in mice fed HFD for 12 weeks or housed at 4°C for 3 weeks (CE), relative to chow fed housed at 23°C (CHOW). n = 7, age 16 weeks.
BMP8B involved in several pathways and played different roles in them. We selected most pathways BMP8B participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP8B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | BMPR1BB;CHRD;CUL1B;ROCK2B;SMAD3;LEFTY2;PPP2CA;GDF7;NDR1 |
| Hippo signaling pathway | WNT7B;JUB;DVL3;AREG;TGFB3;SNAI2;AMH;MOB1A;BMP2 |
BMP8B has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP8B itself. We selected most functions BMP8B had, and list some proteins which have the same functions with BMP8B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| BMP receptor binding | BMP6;BMP7B;PYCARD;BMP7A;BMP8B;BMP3;BMP7;BMP5;BMP2B |
| cytokine activity | IL9;GDF10B;CMTM7;FASLG;GM13278;Flt3l;TGFB2;CCL19A.1;IFNA6 |
| growth factor activity | MDKA;FGF17;FGF10A;LEFTY2;PPBP;INHBA;Fgf15;FGF16;FGF12A |
| transforming growth factor beta receptor binding | BMP5;GDF15;GDF11;GDF2;FKBP1A;NDR1;SMAD3;LEFTY2;INHBAA |
BMP8B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP8B here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP8B.
WFIKKN2; WFIKKN1; ABL1; FYN
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Customer Reviews (3)
Write a reviewThe knowledgeable and responsive support team is dedicated to resolving issues and providing solutions that are tailored to specific experimental requirements.
This enables researchers to confidently incorporate BMP8B into their studies, knowing that they have access to a reliable and well-characterized protein that will contribute to robust and accurate results.
the high-quality BMP8B protein is available in various forms, including recombinant proteins and purified samples, enabling researchers to select the most suitable format for their specific experimental setup.
Q&As (5)
Ask a questionResearch suggests that BMP8B could be a potential target for obesity treatment due to its involvement in metabolic regulation, but more studies are needed to fully understand its therapeutic potential.
BMP8B has been implicated in cardiovascular health, with studies suggesting its involvement in vascular smooth muscle cell function and potential implications for cardiovascular diseases.
The role of BMP8B in cancer is still under investigation. Some studies suggest it may influence cancer cell behavior, but the exact mechanisms are not fully understood.
The potential side effects of manipulating BMP8B levels are not yet fully elucidated, and this is an area of active research.
BMP8B has been associated with female fertility, and studies indicate its involvement in the regulation of ovulation and the menstrual cycle.
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