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Official Full Name bone morphogenetic protein 6
Background The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
Synonyms BMP6; bone morphogenetic protein 6; vegetal related growth factor (TGFB related) , VGR; VGR1; BMP-6; BMP6_HUMAN; Bone Morphogenic Protein 6; Decapentaplegic vegetal related; DVR6; HGNC:12686; TGFB related vegetal related growth factor; Transforming growth factor beta; Vegetal related (TGFB related) cytokine; Vg related sequence; VG-1-R; VG-1-related protein; VGR-1; OTTHUMP00000016006; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related); VGR
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BMP6-015H Recombinant Human BMP6 Protein E. coli
    Human BMP6-162H Recombinant Human BMP6 Protein, Biotinylated NS0 N/A
    Human BMP6-273H Recombinant Human BMP6 Protein, GST-tagged Wheat Germ GST
    Human BMP6-41H Recombinant Human BMP6 HEK293 N/A
    Human BMP6-42H Recombinant Human Bone Morphogenetic Protein 6 E.coli N/A
    Human BMP6-575H Recombinant Human bone morphogenetic protein 6, His-tagged E.coli His
    Human BMP6-5977H Recombinant Human BMP6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BMP6-68H Recombinant Human BMP6 NS0 N/A
    Human BMP6-8430HCL Recombinant Human BMP6 293 Cell Lysate HEK293 N/A
    Mouse BMP6-2433M Recombinant Mouse BMP6 Protein Mammalian Cell His
    Mouse Bmp6-27M Recombinant Mouse Bone Morphogenetic Protein 6 NS0 N/A
    Mouse Bmp6-28M Recombinant Mouse Bmp6 CHO N/A
    Mouse Bmp6-713M Recombinant Mouse Bmp6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat Bmp6-655R Recombinant Rat Bmp6 protein, His-tagged E.coli His
    Rat BMP6-998R Recombinant Rat BMP6 Protein Mammalian Cell His
    Zebrafish BMP6-2125Z Recombinant Zebrafish BMP6 Mammalian Cell His

    bmp6 involved in several pathways and played different roles in them. We selected most pathways bmp6 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with bmp6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway RHOA; NODAL; SMAD9; ID2B; ROCK1; RBX1; NDR1; NOG3; ID2; RPS6KB1
    Hippo signaling pathway INADL; CCND1; PRKCZ; TCF7; MOBKL1A; BMP8B; WNT2B; WWC1; YWHAH; LATS1
    Ovarian steroidogenesis ALOX5; LDLR; BMP6; INS1; CYP2J6; GNAS; INS2; STAR; Adcy4; PRKACG

    bmp6 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by bmp6 itself. We selected most functions bmp6 had, and list some proteins which have the same functions with bmp6. You can find most of the proteins on our site.

    Function Related Protein
    BMP receptor binding BMP8B; BMP4; BMP6; BMP2; BMP7A; BMP7B; PYCARD; BMP7; BMP5; BMP8A
    cytokine activity CLCF1; MSTNB; NDP; VEGFA; GDF7; IFNK; LFT1; CCL20A.3; IL3; IFNA17
    growth factor activity BMP8B; MDK; DKK1; VEGFA; FGF11; HGF; FGF20; JAG1; NDR2; VEGFB
    protein heterodimerization activity UBA2; TGFB1; DR1; SOX8; PDZD7; MYOG; MCL1A; HIST3H2BB; TAF12; THRA
    transforming growth factor beta receptor binding NDR2; GDF11; MSTN; INHA; INHBAA; BMP7B; TGFB1A; GDF10B; GDF6; INHBAB

    bmp6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with bmp6 here. Most of them are supplied by our site. Hope this information will be useful for your research of bmp6.

    Eberlein, C; Rooney, C; et al. E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin alpha v beta 6 and maintained through TGF beta signalling. ONCOGENE 34:704-716(2015).
    Tang, YH; Li, YY; et al. Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25:675-682(2014).


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