BMP6
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Official Full Name
bone morphogenetic protein 6
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Overview
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. -
Synonyms
BMP6; bone morphogenetic protein 6; vegetal related growth factor (TGFB related) , VGR; VGR1; BMP-6; BMP6_HUMAN; Bone Morphogenic Protein 6; Decapentaplegic vegetal related; DVR6; HGNC:12686; TGFB related vegetal related growth factor; Transforming growth factor beta; Vegetal related (TGFB related) cytokine; Vg related sequence; VG-1-R; VG-1-related protein; VGR-1; OTTHUMP00000016006; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related); VGR;
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What is bmp6 protein?
Function: BMP6 stimulates bone formation. It signals through BMP receptors and Smad proteins to induce the expression of osteoblast genes and promote the differentiation of stem cells into osteoblasts (bone-forming cells).
Sources: BMP6 is produced primarily in the liver and circulates in the blood. It also acts locally in bones and other tissues.
Role in bone homeostasis: BMP6 helps maintain bone mass by stimulating bone formation. It counters the bone resorption action of osteoclasts (bone-breaking cells).
Clinical significance: Mutations or deficiencies in BMP6 are associated with reduced bone mineral density and increased fracture risk. BMP6 treatment can help repair bone injuries.
What is the function of bmp6 protein?
Bone formation: BMP6 stimulates stem cell differentiation into osteoblasts, the bone-forming cells. This increases bone matrix production and mineralization.
Bone homeostasis: It counters bone resorption by osteoclasts, maintaining balanced bone remodeling and homeostasis.
Osteoblast regulation: BMP6 induces the expression of genes involved in osteoblast differentiation and function, like Runx2, osterix, osteocalcin etc.
Iron metabolism: It acts as a key regulator of systemic iron balance by inducing hepatic hepcidin expression, which reduces intestinal iron absorption.
Bmp6 related signaling pathway
BMP pathway: BMP6 binds to type 1 (ALK2/3/6) and type 2 (BMPR2) serine/threonine kinase receptors.
Smad pathway: Receptor activation phosphorylates regulatory Smads (R-Smads) 1, 5, and 8. Phospho-R-Smads complex with Co-Smad4 and translocate to the nucleus.
Target gene expression: The Smad complex associates with transcription factors like Runx2 to induce genes responsible for osteoblast differentiation (ALP, OC, OPG etc).
Wnt pathway: BMP6 signaling intersects with the Wnt/β-catenin pathway important for osteogenesis and bone homeostasis.
BMP6 Related Diseases
- Osteoporosis: Deficiencies in BMP6 are linked to low bone mineral density and increased osteoporotic fracture risk.
- Primary iron overload: BMP6 mutation causes hereditary hemochromatosis by impairing hepcidin regulation of iron metabolism.
- Pulmonary diseases: Level changes contribute to pathologies like emphysema, pulmonary fibrosis and neonatal chronic lung disease.
- Liver diseases: Aberrant signaling implicated in conditions ranging from fibrosis to cancer.
- Bone tissue engineering: Promotes osteogenesis and mineralization for treatment of fractures, grafts.
- Osteoporosis therapy: Recombinant BMP6 repairs bone loss through osteoblast activation.
- Iron overload disorders: Rescues hepcidin regulation to treat hereditary hemochromatosis.
- Bone tissue engineering: Promotes osteogenesis and mineralization for treatment of fractures, grafts.
- Osteoporosis therapy: Recombinant BMP6 repairs bone loss through osteoblast activation.
- Iron overload disorders: Rescues hepcidin regulation to treat hereditary hemochromatosis.
High Purity
Fig1. SDS-PAGE (Cat. No.: Bmp6-655R)
(Jun Du, 2007)
Fig2. BMP6 treatment alone in primary cortical cell cultures. At different BMP6 concentrations between 50 ng/ml and 400 ng/ml, BMP6 did not increase cell toxicity.
(Susanna Canali, 2016)
Fig3. Schematic representation of Bmp6 gene structure and the floxed Bmp6 allele. Cre-mediated excision of exons 5 to 7 encoding the mature Bmp6 protein generates a functionally null allele. Genotyping primer positions are indicated.
BMP6 involved in several pathways and played different roles in them. We selected most pathways BMP6 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | NOG;BMP8B;RPS6KB2;THBS1;ID3;NOG3;BMP2;AMHR2;TFDP1 |
| Hippo signaling pathway | SAV1;TCF7L2;FZD1;ACTB;ID2;YAP1;WNT16;DLG3;TEAD2 |
| Ovarian steroidogenesis | PTGS2;PLA2G4D;AKR1C3;ALOX5;PLA2G4A;LHB;PLA2G4C;GNAS;LDLR |
BMP6 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP6 itself. We selected most functions BMP6 had, and list some proteins which have the same functions with BMP6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| BMP receptor binding | BMP4;BMP7B;BMP2;BMP5;BMP8A;BMP8B;BMP7A;BMP6;PYCARD |
| cytokine activity | BMP8B;CMTM7;LEFTY1;IL12BA;BMP4;CMTM4;CD70;CSF2;BMP7A |
| growth factor activity | FGF20A;PDGFAB;INHBE;FGF3;BTC;RABEP1;AMELX;CSF1A;FGF21 |
| protein heterodimerization activity | CXorf15;DRD1A;NTSR1;TAF6L;INHA;HIST1H4I;Itgam&Itgb2;HIST1H2BK;UGT1A6 |
| transforming growth factor beta receptor binding | INHA;GDF10B;USP15;GDF2;BMP8A;SPAW;NDR2;INHBAB;GDF5 |
BMP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP6.
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Customer Reviews (3)
Write a reviewThe BMP6 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.
The BMP6 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.
This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.
Q&As (5)
Ask a questionYes, there are several ongoing clinical trials investigating the therapeutic applications of BMP6, including its use in bone regeneration and the treatment of musculoskeletal disorders.
Yes, BMP6 is often used in combination with other growth factors and scaffolds to enhance its regenerative potential, especially in tissue engineering applications.
No, BMP6's influence extends beyond bone health. It has been implicated in various cellular processes, including iron homeostasis, and its therapeutic potential is being explored in multiple medical fields.
BMP6 has therapeutic potential in treating bone disorders, such as non-union fractures and osteoporosis. Its ability to stimulate bone formation makes it a valuable candidate for regenerative medicine.
BMP6 can be administered both locally and systemically, depending on the therapeutic goals. Local administration is often preferred for targeted effects, such as bone regeneration at a specific site.
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