BMP6

  • Official Full Name

    bone morphogenetic protein 6

  • Overview

    The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
  • Synonyms

    BMP6; bone morphogenetic protein 6; vegetal related growth factor (TGFB related) , VGR; VGR1; BMP-6; BMP6_HUMAN; Bone Morphogenic Protein 6; Decapentaplegic vegetal related; DVR6; HGNC:12686; TGFB related vegetal related growth factor; Transforming growth factor beta; Vegetal related (TGFB related) cytokine; Vg related sequence; VG-1-R; VG-1-related protein; VGR-1; OTTHUMP00000016006; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related); VGR;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BMP6-162H Active Recombinant Human BMP6 Protein, Biotinylated Mammalian cells N/A
Human BMP6-68H Active Recombinant Human BMP6 Mammalian cells N/A
Human BMP6-575H Recombinant Human bone morphogenetic protein 6, His-tagged E.coli His
Human BMP6-273H Recombinant Human BMP6 Protein, GST-tagged Wheat Germ GST
Human BMP6-41H Recombinant Human BMP6 HEK293 N/A
Human BMP6-42H Recombinant Human Bone Morphogenetic Protein 6 E.coli N/A
Human BMP6-8430HCL Recombinant Human BMP6 293 Cell Lysate HEK293 N/A
Human BMP6-5263H Recombinant Human BMP6 protein, His-tagged E.coli His
Human BMP6-281H Active Recombinant Human BMP6 Protein (Val397-His513), C-His tagged, Animal-free, Carrier-free E.coli C-His
Human BMP6-5977H Recombinant Human BMP6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BMP6-015H Active Recombinant Human BMP6 Protein E. coli
Human BMP6-4368H Recombinant Human BMP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BMP6-16H Recombinant Active Human BMP6 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human BMP6-1546H Recombinant Human BMP6 Protein (Ser375-His513), N-His tagged E.coli N-His
Human BMP6-4368H-B Recombinant Human BMP6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Bmp6-28M Active Recombinant Mouse Bmp6 CHO N/A
Mouse BMP6-2433M Recombinant Mouse BMP6 Protein Mammalian Cell His
Mouse Bmp6-27M Recombinant Mouse Bone Morphogenetic Protein 6 Mammalian cells N/A
Mouse Bmp6-10523M-B Recombinant Mouse Bmp6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Bmp6-10523M Recombinant Mouse Bmp6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Bmp6-713M Recombinant Mouse Bmp6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat BMP6-998R Recombinant Rat BMP6 Protein Mammalian Cell His
Rat Bmp6-655R Recombinant Rat Bmp6 protein, His-tagged E.coli His
Rat BMP6-656R-B Recombinant Rat BMP6 Protein Pre-coupled Magnetic Beads HEK293
Rat BMP6-656R Recombinant Rat BMP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish BMP6-2125Z Recombinant Zebrafish BMP6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BMP6 Related Articles
  • BMP6 Related Gene Family
  • BMP6 Related Research Area

BMP6 involved in several pathways and played different roles in them. We selected most pathways BMP6 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TGF-beta signaling pathwayNODAL;GDF6A;AMHR2;LTBP1;SMURF1;BMPR1A;ROCK1;RPS6KB1B;TGFBR1
Hippo signaling pathwayPPP2CA;SERPINE1;PRKCZ;SNAI2;BMP8B;PPP1CC;GDF7;WNT2B;FZD7
Ovarian steroidogenesisALOX5;BMP6;INSR;PTGS2;HSD17B1;FSHR;LDLR;PRKACG;PLA2G4F

BMP6 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP6 itself. We selected most functions BMP6 had, and list some proteins which have the same functions with BMP6. You can find most of the proteins on our site.

Function Related Protein
BMP receptor bindingBMP5;BMP8A;BMP7A;BMP2;BMP4;BMP3;BMP7;PYCARD;BMP6
cytokine activityGm13290;Ifna11;TNFRSF11B;IL19;GDF10;IFNK;WNT5A;BMP2B;IL15L
growth factor activityBMP7A;IL3;CLCF1;IGF1;DKK1;LEFTY1;PPBP;GDF7;NRG4
protein heterodimerization activityHIST1H4E;TYR;TLX1;DRD2;TYRP1;HIST1H3F;HIST1H2AI;NFKB1;NEUROD1
transforming growth factor beta receptor bindingGDF6;LFT1;NDR2;INHBB;GDF9;BMP2B;INHBAA;NDR1;BMP5

BMP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP6.

Eberlein, C; Rooney, C; et al. E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin alpha v beta 6 and maintained through TGF beta signalling. ONCOGENE 34:704-716(2015).
Tang, YH; Li, YY; et al. Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25:675-682(2014).
TGF
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any ongoing clinical trials involving BMP6? 01/27/2022

Yes, there are several ongoing clinical trials investigating the therapeutic applications of BMP6, including its use in bone regeneration and the treatment of musculoskeletal disorders.

Can BMP6 be used in conjunction with other growth factors? 10/09/2017

Yes, BMP6 is often used in combination with other growth factors and scaffolds to enhance its regenerative potential, especially in tissue engineering applications.

Is BMP6 only relevant for bone-related conditions? 11/01/2016

No, BMP6's influence extends beyond bone health. It has been implicated in various cellular processes, including iron homeostasis, and its therapeutic potential is being explored in multiple medical fields.

How does BMP6 contribute to the treatment of bone disorders? 08/08/2016

BMP6 has therapeutic potential in treating bone disorders, such as non-union fractures and osteoporosis. Its ability to stimulate bone formation makes it a valuable candidate for regenerative medicine.

Can BMP6 be administered systemically or is it site-specific? 01/15/2016

BMP6 can be administered both locally and systemically, depending on the therapeutic goals. Local administration is often preferred for targeted effects, such as bone regeneration at a specific site.

Customer Reviews (3)

Write a review
Reviews
08/14/2022

    The BMP6 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

    11/02/2020

      The BMP6 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.

      10/15/2019

        This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

        Ask a Question for All BMP6 Products

        Required fields are marked with *

        My Review for All BMP6 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends