BMP6
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Official Full Name
bone morphogenetic protein 6
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Overview
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. -
Synonyms
BMP6; bone morphogenetic protein 6; vegetal related growth factor (TGFB related) , VGR; VGR1; BMP-6; BMP6_HUMAN; Bone Morphogenic Protein 6; Decapentaplegic vegetal related; DVR6; HGNC:12686; TGFB related vegetal related growth factor; Transforming growth factor beta; Vegetal related (TGFB related) cytokine; Vg related sequence; VG-1-R; VG-1-related protein; VGR-1; OTTHUMP00000016006; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related); VGR;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- CHO
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His(C
- ter)
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- BMP6 Related Articles
- BMP6 Related Gene Family
- BMP6 Related Research Area
BMP6 involved in several pathways and played different roles in them. We selected most pathways BMP6 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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TGF-beta signaling pathway | CUL1A;ROCK1;TFDP1A;CUL1;INHBA;BMPR1A;NBL1;BMP7;NODAL |
Hippo signaling pathway | DLG3;CTGF;DLG1;TGFB1;ID2;TGFB2;WNT8A;SMAD3;PPP2R1A |
Ovarian steroidogenesis | INS2;LDLR;PRKACG;Adcy4;LHB;FSHB;PLA2G4C;CYP2J6;HSD3B6 |
BMP6 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP6 itself. We selected most functions BMP6 had, and list some proteins which have the same functions with BMP6. You can find most of the proteins on our site.
Function | Related Protein |
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BMP receptor binding | BMP8B;BMP7B;BMP6;BMP3;BMP5;BMP7A;BMP2B;BMP7;BMP8A |
cytokine activity | SLURP1;CSF1B;IL23;Il1f9;IFNA21;Gm13290;SPAW;LTA;IL6 |
growth factor activity | FGF12B;MDKB;PDGFB;LFT1;NRG3;F2;BMP7B;IGF2A;THBS4 |
protein heterodimerization activity | RRAGA;MAFGA;IKBKB;HEYL;KCNK3;HIST3H2BB;NR2C2;ZHX2;SYCP2 |
transforming growth factor beta receptor binding | LRG1;INHBAA;INHA;SMURF2;TGFB1A;BMP8B;NDR2;BMP7;INHBA |
BMP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP6.
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, there are several ongoing clinical trials investigating the therapeutic applications of BMP6, including its use in bone regeneration and the treatment of musculoskeletal disorders.
Yes, BMP6 is often used in combination with other growth factors and scaffolds to enhance its regenerative potential, especially in tissue engineering applications.
No, BMP6's influence extends beyond bone health. It has been implicated in various cellular processes, including iron homeostasis, and its therapeutic potential is being explored in multiple medical fields.
BMP6 has therapeutic potential in treating bone disorders, such as non-union fractures and osteoporosis. Its ability to stimulate bone formation makes it a valuable candidate for regenerative medicine.
BMP6 can be administered both locally and systemically, depending on the therapeutic goals. Local administration is often preferred for targeted effects, such as bone regeneration at a specific site.
Customer Reviews (3)
Write a reviewThe BMP6 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.
The BMP6 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.
This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.
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