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BMP7

  • Official Full Name

    bone morphogenetic protein 7

  • Overview

    BMP-7, also known as osteogenic protein 1, is a 431 amino acid secreted protein that belongs to the TGF-beta family. It is expressed in the kidney and bladder as well as in the brain at lower levels. During embryogenesis, BMP-7 is detected in the developing eye, brain, and ear. BMP-7 is consisted of a disulfide-linked homodimer and it interacts with SOSTDC1 and TWSG1. Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. BMP-7 is determined to induce cartilage and bone formation. It may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Moreover, BMP-7 is found to play a role in calcium regulation and bone homeostasis. It is available under the name Osigraft (Stryker) and its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.
  • Synonyms

    RP11-560A15.5, OP-1; osteogenic protein 1; OP-1;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Human
  • Mouse
  • Rat
  • CHO
  • CHO-K1
  • E.coli
  • HEK293
  • Human cells
  • In Vitro Cell Free System
  • Nicotiana Benthamiana
  • Rabbit
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • His(C
  • ter)
  • His|S
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BMP7-163H Active Recombinant Human BMP7 Protein, Biotinylated CHO N/A Ser293-His431
Human BMP7-508H Active Recombinant Human BMP7, HIgG1 Fc-tagged, mutant CHO Fc
Human BMP7-134H Active Recombinant Human BMP7, Animal Free Nicotiana Benthamiana N/A
Human BMP2&BMP7-709H Active Recombinant Human BMP2&BMP7 E.coli N/A
Human BMP7-135H Active Recombinant Human BMP7, Animal Free Nicotiana Benthamiana N/A
Human BMP7-105H Active Recombinant Human BMP7 HEK293 N/A
Human BMP7-01HG Active GMP Recombinant Human BMP-7 Protein CHO-K1
Human BMP7-26285TH Recombinant Human BMP7, His-tagged E.coli His
Human BMP7-274H Recombinant Human BMP7 Protein, GST-tagged Wheat Germ GST
Human BMP7-07H Recombinant Human Bone Morphogenetic Protein 7 CHO N/A
Human BMP7-10H Recombinant Human Bone Morphogenetic Protein 7, His-tagged E.coli His
Human BMP7-03H Recombinant Human BMP7 protein E.coli N/A 139
Human BMP7-27031TH Active Recombinant Human BMP7 protein CHO N/A Met316-His431
Human BMP7-1548H Recombinant human BMP7, Active Nicotiana Benthamiana N/A
Human BMP7-207H Recombinant Human BMP7 protein, His/S-tagged E.coli His/S
Human BMP7-8429HCL Recombinant Human BMP7 293 Cell Lysate HEK293 N/A
Human BMP7-05H Active Recombinant Human BMP7 Protein, Animal Free Human cells
Human BMP7-282H Active Recombinant Human BMP7 Protein (Met315-His431), C-His tagged, Animal-free, Carrier-free E.coli C-His Met315-His431
Human BMP7-2601H Recombinant Human BMP7 protein, GST-tagged E.coli GST 293-431aa
Human BMP7-126HG Active GMP Recombinant Human BMP7 Protein CHO N/A
Human BMP7-0781H Recombinant Human BMP7 Protein (Asp30-His431), His tagged E.coli His Asp30-His431
Human BMP7-1727HF Recombinant Full Length Human BMP7 Protein, GST-tagged In Vitro Cell Free System GST 431 amino acids
Human BMP7-016H Recombinant Human BMP7 protein E.coli N/A
Human BMP7-17H Recombinant Active Human BMP7 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human BMP7-11H Recombinant Human BMP7 protein, His-tagged E.coli His Asp30~His431
Human CPB-1276RH Rabbit Anti-Human BMP 7 Polyclonal Antibody Rabbit N/A
Human BMP7-3994H Recombinant Human BMP7 protein, His-tagged E.coli His 82-431 aa
Mouse Bmp7-589M Active Recombinant Mouse Bmp7 CHO N/A Ser292-His430
Mouse Bmp7-568M Recombinant Mouse Bmp7 protein, His-tagged E.coli His Ser292~His430
Mouse Bmp7-208M Recombinant Mouse Bmp7 protein, His/S-tagged E.coli His/S
Mouse Bmp7-42M Recombinant Mouse Bmp7 protein, His-tagged E.coli His
Rat Bmp7-209R Recombinant Rat Bmp7, His-tagged E.coli His Ser292~His430
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is BMP7 protein?

BMP7 (Bone Morphogenetic Protein 7) is a protein coding gene which situated on the long arm of chromosome 20 at locus 20q13. This gene spans approximately 97.9 kb of genomic DNA. Bone Morphogenetic Protein 7 (BMP7) is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-7 is mainly expressed in kidney and bladder. It is also present in developing eyes, brain and ear during embryogenesis. BMP7 also named osteogenic protein-1 (OP-1) is a potent osteoinductive cytokine and plays role in osteoblast differentiation, SMAD1 production and renal development and repair. Human BMP7 is synthesized with a signal sequence (29 aa.), a propeptide (263 aa.), and a growth factor domain (139 aa.). The growth factor domain of human BMP7 shares 98 % aa. sequence identity with mouse and rat BMP7.

What is the function of BMP7 protein?

BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the proteins encoded by this gene family have a proposed role in early development and possible bone inductive activity. Also, it promotes nephron development, inhibits the branching of prostate epithelium, and antagonizes epithelial-mesenchymal transition (EMT). In pathological conditions, BMP7 inhibits tumour growth and metastasis, ameliorates fibrotic damage in nephritis, and promotes neuroregeneration following brain ischemia.

BMP7 related signaling pathway

BMP7 can significantly inhibit TGF-β through binding with TGF-β receptor and trigger SMAD transcription factors, such as SMAD 1/5/8. Also, it promotes brown adipocyte differentiation by P38 MAPK pathway-mediated activation of target genes, including members of the SOX family of transcription factors.

BMP7 Related Diseases

Various cancer. Transcriptomic data suggested that BMP7 expression may be disrupted in tumor like ovarian carcinoma and may play an important role in the aggressiveness of the disease.

Congenital Heart Defects. It plays an important role in heart development, mutations in the BMP7 gene can cause heart defects.

Ventricular Septal Defect 1. MBP7 can regulate the genes which are responsible for differentiation of cardiomyocytes. Any disturbances of this process may lead to various congenital heart diseases and defects

BMP7-7.jpg

Fig1. Schematic diagrams of the role of mPTD-BMP7 in the diabetic condition.

Biomedical Application of BMP7 Protein

In experimental kidney injury, administration of BMP-7 or inhibition of CTGF have been sufficient to result in striking improvement of renal function and structure. BMP7 treatment inhibited tubular epithelial disruption stimulated by the renal injury of UUO, preventing tubular atrophy and diminishing the activation of tubulointerstitial inflammation and fibrosis and preserving renal function. Additional BMP treatment plus conventional intervention is more effective than conventional intervention alone for union of acute open tibial fractures.

High Purity

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BMP7-2.jpg

Fig2. SDS-PAGE (BMP7-03H)

Case Study 1: João Arezes, 2018

BMP7-3.jpg

Fig1. C2C12 BRE-Luc cells were treated with 2 nM BMP in combination with a gradient of mouse enhances erythroferrone (ERFE) concentrations (7.5 pM to 0.5 μM) for 24 hours, and luminescence was measured in each well. Data were normalized to percentage of maximum luminescence (no ERFE).

Case Study 2: Jinlai Zhan, 2023

BMP7-4.jpg

Fig2. Comparison of BMP-2 and BMP-7 levels. A. BMP-2, B. BMP-7.

BMP7-5.jpg

Fig1. BMP2/4, BMP7, and activin, representing different subgroups of the TGFβ superfamily, can share the type II receptors ActRII and IIB.

BMP7-6.jpg

Fig2. Model of chemotropic BMP signaling indicating the potential asymmetric recruitment of ActRIIA (red) and BMPR2 (yellow) into the tetrameric receptor complex.

BMP7 involved in several pathways and played different roles in them. We selected most pathways BMP7 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIFNGR1;TNFSF11;CD40LG;IL21;IL12B;TGFB2;CXCR4B;TGFB1A;ACVR2AA
TGF-beta signaling pathwayMYCB;CUL1B;BMP5;MAPK1;BMP7B;ID2A;RBL1;SMAD2;SP1
Hippo signaling pathwayWWC1;BMPR1A;BMP5;BMP7;FGF1;STK3;PPP2CA;SCRIB;FBXW11

BMP7 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP7 itself. We selected most functions BMP7 had, and list some proteins which have the same functions with BMP7. You can find most of the proteins on our site.

Function Related Protein
BMP receptor bindingBMP7;BMP3;PYCARD;BMP7A;BMP5;BMP6;BMP2B;BMP8B;BMP8A
cytokine activityCTF1;TNFSF8;IL9;GDF9;IL1RN;CER1;IFNA3;LTA;TGFB1A
growth factor activityAMELX;FGF20;INHBAB;FGF12A;HBEGFA;EREG;THPO;NDR2;VEGFC
heparin bindingADAMTS8;CTGF;CYR61L1;SMOC2;RSPO1;FGFR4;SELL;CTSG;VEGFAB
protein bindingINIP;GNB3;FRMPD1;TAF8;DDIT4L;RELA;PADI4;TLR1;TGM1
transforming growth factor beta receptor bindingSMAD2;INHBE;USP15;BMP7;INHBC;BMP2;MSTN;TGFB2;BMP3

BMP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP7.

Acvr2a; NOG; MTUS2

Gene Family

TGF

Research Area

Related articles

Siddique, I; Curran, SP; et al. Gremlin Promotes Peritoneal Membrane Injury in an Experimental Mouse Model and Is Associated with Increased Solute Transport in Peritoneal Dialysis Patients. AMERICAN JOURNAL OF PATHOLOGY 184:2976-2984(2014).
Khurana, S; Melacarne, A; et al. SMAD Signaling Regulates CXCL12 Expression in the Bone Marrow Niche, Affecting Homing and Mobilization of Hematopoietic Progenitors. STEM CELLS 32:3012-3022(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any potential side effects or risks associated with BMP7 treatment? 01/31/2023

Yes, potential side effects include inflammation, swelling, and in rare cases, excessive bone growth.

How does BMP7 contribute to bone healing? 03/08/2022

BMP7 stimulates the differentiation of mesenchymal stem cells into osteoblasts, promoting bone formation and repair.

Can BMP7 be used in spinal fusion surgeries? 05/13/2021

Yes, BMP7 is often used in spinal fusion surgeries to stimulate bone growth and enhance the fusion process.

In what medical conditions is BMP7 protein commonly used? 02/08/2018

BMP7 is commonly used in conditions such as bone fractures, spinal fusions, and non-union fractures.

Is BMP7 exclusively used in orthopedic applications? 01/13/2017

While orthopedics is a primary application, BMP7 is also being explored for its potential in treating kidney and eye disorders.

Customer Reviews (3)

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Reviews
01/08/2022

    By incorporating the BMP7 protein into electron microscopy studies, researchers gain insights into the intricate three-dimensional architecture of proteins, facilitating a deeper comprehension of their functions and aiding in the development of novel therapeutics.

    04/26/2021

      Its reliability and effectiveness in generating accurate data make it an indispensable resource, driving scientific exploration and advancing our understanding of protein structure and function

      05/13/2017

        The BMP7 protein is an exceptional product that meets the highest standards of quality, making it an ideal choice to fulfill my experimental requirements.

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