bmp7 Protein, bone morphogenetic protein 7

bmp7

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bmp7

Official Full Name bone morphogenetic protein 7
Background BMP-7, also known as osteogenic protein 1, is a 431 amino acid secreted protein that belongs to the TGF-beta family. It is expressed in the kidney and bladder as well as in the brain at lower levels. During embryogenesis, BMP-7 is detected in the developing eye, brain, and ear. BMP-7 is consisted of a disulfide-linked homodimer and it interacts with SOSTDC1 and TWSG1. Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. BMP-7 is determined to induce cartilage and bone formation. It may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Moreover, BMP-7 is found to play a role in calcium regulation and bone homeostasis. It is available under the name Osigraft (Stryker) and its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.
Synonyms RP11-560A15.5, OP-1; osteogenic protein 1; OP-1
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Nicotiana Benthamiana
    • Rabbit
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • S
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BMP2&BMP7-709H Recombinant Human BMP2&BMP7 E.coli N/A
    Human BMP7-03H Recombinant Human BMP7 protein E.coli N/A
    Human BMP7-07H Recombinant Human Bone Morphogenetic Protein 7 CHO N/A
    Human BMP7-105H Recombinant Human BMP7 HEK293 N/A
    Human BMP7-10H Recombinant Human Bone Morphogenetic Protein 7, His-tagged E.coli His
    Human BMP7-126HG GMP Recombinant Human BMP7 Protein CHO N/A
    Human BMP7-134H Recombinant Human BMP7 Nicotiana Benthamiana N/A
    Human BMP7-135H Recombinant Human BMP7 Active Nicotiana Benthamiana N/A
    Human BMP7-1548H Recombinant human BMP7, Active Nicotiana Benthamiana N/A
    Human BMP7-163H Recombinant Human BMP7 Protein, Biotinylated CHO N/A
    Human BMP7-207H Recombinant Human BMP7 protein, His/S-tagged E.coli His/S
    Human BMP7-26285TH Recombinant Human BMP7, His-tagged E.coli His
    Human BMP7-27031TH Recombinant Human BMP7 CHO N/A
    Human BMP7-274H Recombinant Human BMP7 Protein, GST-tagged Wheat Germ GST
    Human BMP7-508H Recombinant Human BMP7, HIgG1 Fc-tagged, mutant CHO Fc
    Human BMP7-8429HCL Recombinant Human BMP7 293 Cell Lysate HEK293 N/A
    Human CPB-1276RH Rabbit Anti-Human BMP 7 Polyclonal Antibody Rabbit N/A
    Mouse Bmp7-208M Recombinant Mouse Bmp7 protein, His/S-tagged E.coli His/S
    Mouse Bmp7-42M Recombinant Mouse Bmp7 protein, His-tagged E.coli His
    Mouse Bmp7-568M Recombinant Mouse Bmp7 protein, His-tagged E.coli His
    Mouse Bmp7-589M Recombinant Mouse Bmp7 CHO N/A
    Rat Bmp7-209R Recombinant Rat Bmp7 protein, His/S-tagged E.coli His/S

    bmp7 involved in several pathways and played different roles in them. We selected most pathways bmp7 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with bmp7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL17B; IL18; TNFRSF6B; HGF; TNFRSF9A; IL24; IL12RB2; TNFSF13B; INHBA; CTF1
    TGF-beta signaling pathway TGFB1A; RHOAD; EP300; INHBC; ACVR2AA; TGIF1; GDF5; RHOAA; AMHR2; NOG
    Hippo signaling pathway WNT10B; BMPR1B; FZD8; WNT3; GDF5; WNT11; Fzd4; MOB1A; PPP2R1A; TGFB2

    bmp7 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by bmp7 itself. We selected most functions bmp7 had, and list some proteins which have the same functions with bmp7. You can find most of the proteins on our site.

    Function Related Protein
    BMP receptor binding PYCARD; BMP6; BMP7; BMP4; BMP8B; BMP2B; BMP2; BMP3; BMP7B; BMP5
    cytokine activity SCGB3A1; IL16; CER1; GDF2; IL15; BMP5; GREM1; Il23a; Il12b; IFNA14; IFNA8
    growth factor activity IL6; Il2; LEFTY2; NDP; CD320; CXCL1; FGF11; RABEP2; IGF2; COL20A1
    heparin binding COL5A1; Epy; COL25A1; ABI3BP; PCOLCE; NRP2; SFRP1; CTSG; ADAMTSL5; HSD17B12
    protein binding PHF17; SYT7; HSP90AA1; TMPRSS7; TAF1B; DYNLL1; MAPK4; LPAL2; ISL1; GRIN3A
    transforming growth factor beta receptor binding INHBE; NODAL; LFT2; GDF3; INHA; GDF11; GDF15; LEFTY2; GDF5; BMP7A

    bmp7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with bmp7 here. Most of them are supplied by our site. Hope this information will be useful for your research of bmp7.

    Acvr2a; NOG; MTUS2

    Siddique, I; Curran, SP; et al. Gremlin Promotes Peritoneal Membrane Injury in an Experimental Mouse Model and Is Associated with Increased Solute Transport in Peritoneal Dialysis Patients. AMERICAN JOURNAL OF PATHOLOGY 184:2976-2984(2014).
    Khurana, S; Melacarne, A; et al. SMAD Signaling Regulates CXCL12 Expression in the Bone Marrow Niche, Affecting Homing and Mobilization of Hematopoietic Progenitors. STEM CELLS 32:3012-3022(2014).

    TGF

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