Recombinant Human F11R Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: F11R-6491H
• Product Overview: F11R MS Standard C13 and N15-labeled recombinant protein (NP_653087) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 32.6 kDa
• AA Sequence: MGTKAQVERKLLCLFILAILLCSLA LGSVTVHSSEPEVRIPENNPVKLSC AYSGFSSPRVEWKFDQGDTTRLVCY NNKITASYEDRVTFLPTGITFKSVT REDTGTYTCMVSEEGGNSYGEVKVK LIVLVPPSKPTVNIPSSATIGNRAV LTCSEQDGSPPSEYTWFKDGIVMPT NPKSTRAFSNSSYVLNPTTGELVFD PLSASDTGEYSCEARNGYGTPMTSN AVRMEAVERNVGVIVAAVLVTLILL GILVFGIWFAYSRGHFDRTKKGTSS KKVIYSQPSARSEGEFKQTSSFLVT RTRPLEQKLISEEDLAANDILDYKD DDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: F11R F11 receptor [ Homo sapiens (human) ]
• Official Symbol: F11R
• Synonyms: F11R; F11 receptor; JAM1, junctional adhesion molecule 1; junctional adhesion molecule A; CD321; JAM 1; JAM A; JAMA; JCAM; PAM 1; platelet F11 receptor; platelet adhesion molecule 1; junctional adhesion molecule 1; JAM; KAT; JAM1; PAM-1
• Gene ID: 50848
• mRNA Refseq: NM_144504
• Protein Refseq: NP_653087
• MIM: 605721
• UniProt ID: Q9Y624