F9

  • Official Full Name

    coagulation factor IX

  • Overview

    Factor IX (or Christmas factor) (EC 3.4.21.22) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to hemophilia.
  • Synonyms

    coagulation facto; F9; FIX; P19; PTC; HEMB; MGC129641; MGC129642; coagulation factor IX; FIX F9; factor 9; Christmas factor; OTTHUMP00000024154; plasma thromboplastic component;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Chicken
  • Cynomolgus
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Vaccinia virus (strain L-IVP) (VACV)
  • E.coli
  • E.coli expression system
  • HEK293
  • Human
  • Human Cell
  • Human Plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse Plasma
  • Plasma
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
  • KSI
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human F9-258H Active Recombinant Human F9 protein, Fc-tagged HEK293 Fc
Human F9-4350H Active Recombinant Human Factor-IX Human N/A
Human F9-26523H Active Native Human F9 Protein Plasma
Human F9-1157H Active Recombinant Human F9 protein, His-tagged HEK293 His Met1-Thr461
Human F9-12627H Recombinant Human F9, His-tagged E.coli His 129-395a.a.
Human F9-3626H Recombinant Human F9 Protein, GST-tagged Wheat Germ GST
Human F9-7807H Recombinant Human F9 protein, His-tagged E.coli His Asp232~Lys455 (Accession # P00740)
Human F9-1849HCL Recombinant Human F9 cell lysate Human Cell N/A
Human F9-P026H Recombinant Human F9 therapeutic protein N/A 415 Aa
Human F9-23H Human Blood Coagulation Factor IX Reference standard N/A
Human F9-26523TH Native Human F9 N/A
Human F9-163H Recombinant Human Blood Coagulation Factors Ixa Reference standard N/A
Human F9-4418HF Recombinant Full Length Human F9 Protein, GST-tagged In Vitro Cell Free System GST 461 amino acids
Human F9-4098H Recombinant Human F9 Protein (Met1-Thr461), C-His tagged Mammalian cells C-His Met1-Thr461
Human F9-2057H Recombinant Human F9 Protein (Thr29-Thr461), C-His tagged Mammalian cells C-His Thr29-Thr461
Human F9-671H Native Human Coagulation Factor IX Human Plasma N/A
Human F9-2311H Recombinant Human F9 Protein (Asp232-Lys455), His tagged E.coli His Asp232-Lys455
Human F9-259H Recombinant Human F9 protein (Met1-Thr467), hFc-tagged HEK293 hFc
Human F9-2502H Recombinant Human F9 protein(51-120 aa), C-His-tagged E.coli C-His 51-120 aa
Human F9-013H Active Recombinant Human F9 Protein, His-tagged HEK293 His 29-461
Human F9-1299H Recombinant Human F9 protein, His-KSI-tagged E.coli N-His-KSI 144-239aa
Mouse F9-7808M Recombinant Mouse F9 protein, His-tagged E.coli His Glu241~Trp463 (Accession # P16294)
Mouse F9-6926M F9-6926M HEK293 His Met 1-Thr 471
Mouse F9-1768MCL Recombinant Mouse F9 cell lysate Human Cell N/A
Mouse F9-5405M Native Mouse Coagulation Factor IX Mouse Plasma N/A
Rat F9-2181R Recombinant Rat F9 Protein Mammalian Cell His
Rat F9-312R Recombinant Rat F9 protein, His-tagged E.coli His
Rat F9-300R Native Rat Factor IX N/A
Rat F9-301R Native Rat Factor IXa N/A
Rat F9-1838R Recombinant Rat F9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat F9-1838R-B Recombinant Rat F9 Protein Pre-coupled Magnetic Beads HEK293
Rabbit F9-7809R Recombinant Rabbit F9 protein, His & GST-tagged E.coli His/GST Met1~Arg146 (Accession # G1U9U2)
Rabbit F9-914R Recombinant Rabbit F9 Protein, His-tagged E.coli N-His IIe228-Lys460
Rabbit F9-915R Recombinant Rabbit F9 Protein, His-tagged E.coli N-His Met1-Thr462
Bovine F9-266B Active Native Bovine Factor IX Plasma N/A
Bovine F9-0496B Recombinant Bovine F9 Protein (Leu244-Thr387), N-His-tagged E.coli N-His Leu244-Thr387
Cattle F9-7806C Recombinant Cattle F9 protein, His-tagged E.coli His Leu273~Thr416 (Accession # P00741)
Cynomolgus F9-1296C Active Recombinant Cynomolgus F9 protein, His-tagged HEK293 His Thr 29 - Thr 461
Rhesus Macaque F9-1533R Recombinant Rhesus monkey F9 Protein, His-tagged Mammalian Cell His
Rhesus Macaque F9-1358R-B Recombinant Rhesus Macaque F9 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque F9-1358R Recombinant Rhesus Macaque F9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Vaccinia virus (strain L-IVP) (VACV) RFL29862VF Recombinant Full Length Vaccinia Virus Protein F9 (F9) Protein, His-Tagged E.coli expression system His Full Length (1-212)
Chicken F9-5915C Recombinant Chicken F9 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

F9 involved in several pathways and played different roles in them. We selected most pathways F9 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesCD59A;FGA;KLKB1;PLAU;C4BP;SERPINF2;F10;C4BPB;C5AR1

F9 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F9 itself. We selected most functions F9 had, and list some proteins which have the same functions with F9. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCDHR1A;PCDH2G29;STIM1;CRELD2;PCDHGB1;C1rb;MFGE8B;OCM2;SLC25A13
endopeptidase activityMMP9;FURIN;PSMB1;SENP5;KLK1B24;P4HB;PSMB9A;HTRA3;PSMA6
serine-type endopeptidase activityHTRA1;HABP2;F7I;HTRA1B;KLK1B24;KLK15;GM5077;TPSAB1;KLK1B26

F9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F9 here. Most of them are supplied by our site. Hope this information will be useful for your research of F9.

GAMMAHV.ORF33

Research Area

Related articles

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Anderson, DR; Cameron, AC; et al. WASP-20b and WASP-28b: a hot Saturn and a hot Jupiter in near-aligned orbits around solar-type stars. ASTRONOMY & ASTROPHYSICS 575:-(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the function of F9 protein? 12/18/2019

The F9 protein is involved in step IX in the coagulation cascade, which works synergistically with other coagulation factors to promote the normal progress of blood clotting.

How do genetic mutations in the F9 protein affect its function? 12/04/2019

Mutations in the F9 gene may lead to loss of protein expression, structural abnormalities, or dysfunction, which in turn affect the normal function of the F9 protein.

Do F9 protein mutations cause other diseases or affect other physiological processes? 05/27/2019

F9 protein mutations are primarily associated with hemophilia B, but the specific mutation type and location may have different effects on an individual's clinical presentation.

What diseases can F9 gene mutations cause? 05/22/2019

Mutations in the F9 gene may cause hemophilia B, an inherited coagulation disorder in which patients lack the F9 protein or have low activity and are prone to abnormal bleeding.

How is the activity of F9 protein determined? 04/08/2019

The activity of the F9 protein is usually measured by coagulation time or by specific experimental methods (eg, prothrombin time, activated partial thromboplastin time, etc.).

What is the structure of F9 protein? 01/31/2019

F9 protein is a single-chain glycoprotein consisting of 415 amino acids. It contains a signaling peptide and multiple functional regions in which the Gla domain at the C-terminal binds to calcium ions and the EGF-like domain at the N-terminus participates in receptor binding and activation.

Customer Reviews (3)

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Reviews
04/15/2021

    The short half-life makes this product very safe.

    10/10/2020

      This protein has a wide range of applications and can be used in a variety of experiments.

      03/27/2019

        The method of use is simple, which reduces the experimental time and improves the efficiency.

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