F12

  • Official Full Name

    coagulation factor XII

  • Overview

    Coagulation factor XII also known as Hageman factor is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC 3.4.21.38) of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by the F12 gene.
  • Synonyms

    coagulation factor XII (Hageman factor); F12; HAF; HAE3; HAEX; coagulation factor XII; Hageman factor; OTTHUMP00000223845; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain;

  • Native Proteins
  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • HEK293
  • HEK293F
  • Human plasma
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human F12-5397H Active Native Human Coagulation Factor XII (Hageman factor) Human plasma N/A
Human F12-3606H Recombinant Human F12 Protein, GST-tagged Wheat Germ GST
Human F12-12617H Recombinant Human F12 protein, His-tagged E.coli His 316-615 aa
Human F12 -82H Recombinant Human Factor XII Insect Cell N/A
Human F12-773H Recombinant Human F12 protein, His & T7-tagged E.coli His/T7 Ser400~Ser615 (Accession # P00748)
Human F12-2115HCL Recombinant Human F12 cell lysate N/A
Human F12-4483HF Recombinant Full Length Human F12 Protein, GST-tagged In Vitro Cell Free System GST 300 amino acids
Human F12-2424H Recombinant Human F12 Protein (Met316-Ser615), N-His tagged E.coli N-His Met316-Ser615
Human F12-28805TH Native Human F12 N/A
Human F12-13H Native Human Factor beta-XIIa, Biotin Labeled Human plasma N/A
Mouse F12-5406M Recombinant Mouse F12 Protein Mammalian Cell His
Mouse F12-774M Recombinant Mouse F12 protein, His & T7-tagged E.coli His/T7 Phe352~Tyr587 (Accession # Q80YC5)
Mouse F12-2916M-B Recombinant Mouse F12 Protein Pre-coupled Magnetic Beads HEK293
Mouse F12-909M Recombinant Mouse F12 Protein, His-tagged HEK293F N-His Ala20-Ser597
Mouse F12-2916M Recombinant Mouse F12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat F12-2176R Recombinant Rat F12 Protein Mammalian Cell His
Rat F12 -101R Recombinant Rat Coagulation Factor XII Insect Cell N/A
Rat F12-1833R Recombinant Rat F12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat F12-3228R Recombinant Rat F12 protein, His-tagged E.coli His Val354~Phe595
Rat F12-3285R Recombinant Rat F12 protein, His-GST-tagged E.coli His/GST Val354~Phe595
Rat F12-1833R-B Recombinant Rat F12 Protein Pre-coupled Magnetic Beads HEK293
Rat F12-3288R Recombinant Rat F12 protein, His-tagged E.coli His Ala20~Arg353
Rat F12-3287R Recombinant Rat F12 protein, His-tagged E.coli His Val354~Phe595
Rat F12-3286R Recombinant Rat F12 protein, His-SUMO-tagged E.coli His-SUMO Val354~Phe595
Rat F12-3291R Recombinant Rat F12 protein, His-tagged E.coli His Ala20~Arg353
Rat F12-3290R Recombinant Rat F12 protein, His-SUMO-tagged E.coli His-SUMO Ala20~Arg353
Rat F12-3289R Recombinant Rat F12 protein, His-GST-tagged E.coli His/GST Ala20~Arg353
Rat F12-3310R Recombinant Rat F12 protein, His-tagged HEK293 His Val354~Phe595
Pig F12-2005P Recombinant Pig F12 Protein (20-371 aa), His-tagged E.coli His 20-371 aa
Pig F12-2040P Recombinant Pig F12 Protein (20-371 aa), His-tagged Yeast His 20-371 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

F12 involved in several pathways and played different roles in them. We selected most pathways F12 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesVWF;C3AR1;CFD;F10;C3;CD46;C1RA;SERPINC1;F5

F12 has several biochemical functions, for example, misfolded protein binding, protein binding, serine-type aminopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F12 itself. We selected most functions F12 had, and list some proteins which have the same functions with F12. You can find most of the proteins on our site.

Function Related Protein
misfolded protein bindingHDAC6;TOR1A;STUB1;HSPD1;CLU;BAG6;HSPA5;SDF2L1;DNAJC10
protein bindingCTSK;CALM3;XRCC2;TLX1;MAPK4;FAT4;TCEB1;PPP2R1A;TMPO
serine-type aminopeptidase activity
serine-type endopeptidase activityPRSS22;HTRA3;F11;CFB;RHBDD3;GZME;PRSS1;PCSK2;GZMM

F12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F12 here. Most of them are supplied by our site. Hope this information will be useful for your research of F12.

KNG1; C1QBP; GP1BA

Gene Family

TNF Kinesins (KIF)

Research Area

Related articles

Karton, A; Goerigk, L; et al. Accurate Reaction Barrier Heights of Pericyclic Reactions: Surprisingly Large Deviations for the CBS-QB3 Composite Method and Their Consequences in DFT Benchmark Studies. JOURNAL OF COMPUTATIONAL CHEMISTRY 36:622-632(2015).
Ohnishi, Y; Ishimura, K; et al. Massively Parallel MP2-F12 Calculations on the K Computer. INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY 115:333-341(2015).
  • Reviews
  • Q&As

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06/23/2023

    Trustworthy data source. Valuable for our experiments.

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      03/26/2018

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        Q&As (7)

        Ask a question
        What role does F12 play in thrombotic disorders? 05/30/2023

        Abnormalities in F12 can lead to increased risk of thrombosis and related disorders.

        How do genetic variations in the F12 gene affect coagulation and risk of bleeding or clotting disorders? 03/26/2022

        Genetic mutations in F12 can result in either excessive bleeding or an increased tendency to form clots.

        How does F12 interact with other components of the coagulation and fibrinolytic systems? 10/01/2021

        F12 works in conjunction with other coagulation factors and proteins to regulate clot formation and breakdown.

        What is the impact of altered F12 activity on inflammation and immune response? 04/28/2021

        Altered F12 activity is associated with inflammation and can influence immune responses.

        What potential therapeutic applications could arise from targeting F12 in clotting or inflammatory disorders? 12/29/2019

        Targeting F12 offers potential in treating clotting disorders and reducing inflammation in certain conditions.

        How does F12 activation initiate the intrinsic pathway of coagulation? 10/05/2018

        Upon activation, F12 triggers a series of enzymatic reactions leading to clot formation.

        What is the primary function of Factor XII (F12) in the blood coagulation cascade? 03/23/2017

        Factor XII (F12) activates the intrinsic pathway of the coagulation cascade, crucial for blood clot formation.

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