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Official Full Name coagulation factor XII
Background Coagulation factor XII also known as Hageman factor is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by the F12 gene.
Synonyms coagulation factor XII (Hageman factor); F12; HAF; HAE3; HAEX; coagulation factor XII; Hageman factor; OTTHUMP00000223845; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain
    • Species :
    • Human
    • Mouse
    • Pig
    • Rat
    • Source :
    • E.coli
    • Human plasma
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human F12 -82H Recombinant Human Factor XII Insect Cell N/A
    Human F12-12617H Recombinant Human F12, His-tagged E.coli His
    Human F12-13H Native Human Factor beta-XIIa, Biotin Labeled Human plasma N/A
    Human F12-2115HCL Recombinant Human F12 cell lysate N/A
    Human F12-28805TH Native Human F12 N/A
    Human F12-3606H Recombinant Human F12 Protein, GST-tagged Wheat Germ GST
    Human F12-5397H Native Human Coagulation Factor XII (Hageman factor) Human plasma N/A
    Human F12-773H Recombinant Human F12 protein, His & T7-tagged E.coli His/T7
    Mouse F12-5406M Recombinant Mouse F12 Protein Mammalian Cell His
    Mouse F12-774M Recombinant Mouse F12 protein, His & T7-tagged E.coli His/T7
    Rat F12 -101R Recombinant Rat Coagulation Factor XII Insect Cell N/A
    Rat F12-2176R Recombinant Rat F12 Protein Mammalian Cell His
    Pig F12-2005P Recombinant Pig F12 Protein (20-371 aa), His-tagged E.coli His
    Pig F12-2040P Recombinant Pig F12 Protein (20-371 aa), His-tagged Yeast His

    f12 involved in several pathways and played different roles in them. We selected most pathways f12 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with f12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades C8B; C7; MASP1; C1R; F13B; C6; C1RA; C1S; C4BPB; C2

    f12 has several biochemical functions, for example, misfolded protein binding, protein binding, serine-type aminopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by f12 itself. We selected most functions f12 had, and list some proteins which have the same functions with f12. You can find most of the proteins on our site.

    Function Related Protein
    misfolded protein binding HDAC6; STUB1; HSPD1; TOR1A; EDEM1; DNAJB9; SDF2L1; BAG6; CLU; F12
    protein binding TTC25; GRIFIN; CSRNP2; UBE2D2; EAF2; SMCO4; NXT1; NUMBL; JAM2A; MED22
    serine-type aminopeptidase activity F12
    serine-type endopeptidase activity PLAUB; KLK12; PRSS59.1; C1rb; HTRA1A; CELA3B; KLK8; KLK1B22; PRSS40; TMPRSS11G

    f12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with f12 here. Most of them are supplied by our site. Hope this information will be useful for your research of f12.

    KNG1; C1QBP; GP1BA

    Karton, A; Goerigk, L; et al. Accurate Reaction Barrier Heights of Pericyclic Reactions: Surprisingly Large Deviations for the CBS-QB3 Composite Method and Their Consequences in DFT Benchmark Studies. JOURNAL OF COMPUTATIONAL CHEMISTRY 36:622-632(2015).
    Ohnishi, Y; Ishimura, K; et al. Massively Parallel MP2-F12 Calculations on the K Computer. INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY 115:333-341(2015).

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