F12
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Official Full Name
coagulation factor XII
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Overview
Coagulation factor XII also known as Hageman factor is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC 3.4.21.38) of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by the F12 gene. -
Synonyms
coagulation factor XII (Hageman factor); F12; HAF; HAE3; HAEX; coagulation factor XII; Hageman factor; OTTHUMP00000223845; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain;
- Native Proteins
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Pig
- Rat
- E.coli
- HEK293
- HEK293F
- Human plasma
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- Fc
- Avi
- SUMO
- T7
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
F12 involved in several pathways and played different roles in them. We selected most pathways F12 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | SERPING1;F3;CFH;THBD;SERPINC1;C8G;C1QC;Serpina1c;C4BPA |
F12 has several biochemical functions, for example, misfolded protein binding, protein binding, serine-type aminopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F12 itself. We selected most functions F12 had, and list some proteins which have the same functions with F12. You can find most of the proteins on our site.
Function | Related Protein |
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misfolded protein binding | STUB1;EDEM1;DNAJB9;DNAJC10;SDF2L1;HDAC6;HSPA5;DNAJC3;F12 |
protein binding | SSX3;MED25;RELA;TEN1;CDKN1A;CYTH3;SWAP70;NXF3;LAMTOR2 |
serine-type aminopeptidase activity | |
serine-type endopeptidase activity | KLK2;KLK6;MMP2;CFB;KLK8;PRSS2;TPSAB1;KLK7;MCPT2 |
F12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F12 here. Most of them are supplied by our site. Hope this information will be useful for your research of F12.
KNG1; C1QBP; GP1BA
Gene Family
Research Area
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Q&As (7)
Ask a questionAbnormalities in F12 can lead to increased risk of thrombosis and related disorders.
Genetic mutations in F12 can result in either excessive bleeding or an increased tendency to form clots.
F12 works in conjunction with other coagulation factors and proteins to regulate clot formation and breakdown.
Altered F12 activity is associated with inflammation and can influence immune responses.
Targeting F12 offers potential in treating clotting disorders and reducing inflammation in certain conditions.
Upon activation, F12 triggers a series of enzymatic reactions leading to clot formation.
Factor XII (F12) activates the intrinsic pathway of the coagulation cascade, crucial for blood clot formation.
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