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F5

  • Official Full Name

    coagulation factor V (proaccelerin, labile factor)

  • Overview

    Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. Deficiency leads to predisposition for hemorrhage, while some mutations (most notably factor V Leiden) predispose for thrombosis. Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin. Factor Va is composed of a heavy chain and a light chain, noncovalently bound. The interaction between the two chains is calcium-dependent. Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Defects in F5 are the cause of Owren parahemophilia which is an hemorrhagic diastesis. Defects in F5 are the cause of resistance to activated protein C (APCR). APCR is a form of thrombophilia. The APCR mutation is found in about 5% of the population which suggest that a slight thrombotic tendency may confer some advantage in fetal implantation.
  • Synonyms

    F5; FVL; PCCF; coagulation factor V; factor V Leiden; OTTHUMP00000032547; OTTHUMP00000032548; proaccelerin, labile factor; activated protein c cofactor; coagulation factor V jinjiang A2 domain; coagulation factor V (proaccelerin, labile factor);

  • Recombinant Proteins
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Human
  • Mouse
  • Pig
  • Rat
  • Snake
  • Zebrafish
  • E.coli
  • HEK293
  • Human plasma
  • Human Plasma
  • Mammalian Cell
  • Plasma
  • Snake Venom
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human F5-766H Recombinant Human F5 protein, His-tagged E.coli His Phe463~Pro715 (Accession # P12259)
Human F5-768H Recombinant Human F5 protein, His-tagged E.coli His Arg1908~Val2203 (Accession # P12259)
Human F5-767H Recombinant Human F5 protein, His-tagged E.coli His Gln1979~Glu2217 (Accession # P12259)
Human F5-3621H Recombinant Human F5 Protein, GST-tagged Wheat Germ GST
Human F5-2879H Recombinant Human F5 protein, His-SUMO-tagged E.coli His-SUMO 1490-1614aa
Human F5-1176H Native Human Coagulation Factor V (proaccelerin, labile factor) Human Plasma N/A
Human F5-12H Blood Coagulation Factor V Reference standard N/A
Human F5-5300H Native Human Coagulation Factor V (proaccelerin, labile factor) Human plasma N/A
Mouse F5-5414M Recombinant Mouse F5 Protein Mammalian Cell His
Mouse F5-770M Recombinant Mouse F5 protein, His-tagged E.coli His Pro364~Cys611 (Accession # O88783)
Mouse F5-769M Recombinant Mouse F5 protein, His-tagged E.coli His Asp1863-Arg2161 (Accession # O88783)
Mouse F5-771M Recombinant Mouse F5 protein, His-tagged E.coli His Gly1776~Pro2028 (Accession # O88783)
Mouse F5-2922M-B Recombinant Mouse F5 Protein Pre-coupled Magnetic Beads HEK293
Mouse F5-2922M Recombinant Mouse F5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat F5-910R Recombinant Rat F5 Protein, His-tagged E.coli N-His Cys1944-Cys2099
Bovine F5-284B Active Native Bovine Factor V Plasma N/A
Cattle F5-764C Recombinant Cattle F5 protein, His & GST-tagged E.coli His/GST Cys1894~Gly2047 (Accession # Q28107)
Cattle F5-765C Recombinant Cattle F5 protein, His & T7-tagged E.coli His/T7 Lys30~Lys327 (Accession # Q28107)
Snake F5-29S Native Snake Russells Viper Venom Factor V Activator Snake Venom N/A
Zebrafish F5-1669Z Recombinant Zebrafish F5 Mammalian Cell His
Pig F5-772P Recombinant Pig F5 protein, His-tagged E.coli His Cys1941~Cys2095
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • F5 Related Articles
  • F5 Related Gene Family
  • F5 Related Research Area

F5 involved in several pathways and played different roles in them. We selected most pathways F5 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesPROS1;F7;CR2;SERPINC1;Hc;TFPI;KNG1;F2R;MASP1

F5 has several biochemical functions, for example, copper ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F5 itself. We selected most functions F5 had, and list some proteins which have the same functions with F5. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingTYRP1;CUTC;COX11;APOA4;TP53;TYRP1B;F5;TRP53;CCC2
protein bindingZCCHC8;NIPBL;INCENP;SH3BP4;RDBP;PTRF;SOCS7;FTH1;CRYBA2

F5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F5 here. Most of them are supplied by our site. Hope this information will be useful for your research of F5.

BJLF1

Calliari, CM; de Souza, EL; et al. Characterisation and microstructure of reduced-fat chicken patties made with a novel polymer from Agrobacterium radiobacter k84. FOOD CHEMISTRY 173:1150-1157(2015).
Nuzzo, F; Bulato, C; et al. Characterization of an apparently synonymous F5 mutation causing aberrant splicing and factor V deficiency. HAEMOPHILIA 21:241-248(2015).
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