F7
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Official Full Name
coagulation factor VII (serum prothrombin conversion accelerator)
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Overview
Factor VII (formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme (EC 3.4.21.21) of the serine protease class. A recombinant form of human factor VIIa (NovoSeven, eptacog alfa [activated]) has U.S. Food and Drug Administration approval for uncontrolled bleeding in hemophilia patients. It is often used unlicensed in severe uncontrollable bleeding, although there has been safety concerns. -
Synonyms
F7; coagulation factor VII; SPCA; eptacog alfa; proconvertin; OTTHUMP00000018733; OTTHUMP00000018734; FVII coagulation protein; serum prothrombin conversion accelerator; factor VII;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Therapeutic Proteins
- Antibody
- Cattle
- Chicken
- Human
- Mouse
- Rabbit
- Rat
- Rhesus Macaque
- Zebrafish
- CHO
- E. coli
- E.coli
- Hamster Kidney
- HEK293
- HEK293T
- Human Cell
- Human Plasma
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Rabbit
- Wheat Germ
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- His|GST
- His|T7
- SUMO
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- F7 Related Articles
- F7 Related Gene Family
- F7 Related Research Area
F7 involved in several pathways and played different roles in them. We selected most pathways F7 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | F2;CR1L;BDKRB1;C4BP;MASP2;Hc;KNG1;C4BPA;CD59A |
F7 has several biochemical functions, for example, calcium ion binding, glycoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F7 itself. We selected most functions F7 had, and list some proteins which have the same functions with F7. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | CASQ1A;LALBA;PRF1;MFGE8A;GUCA1C;S100A16;FREM1A;MYL3;SCUBE2 |
glycoprotein binding | LMAN2;HFE2;CSNK1D;LDLR;Itgam&Itgb2;SDCBP;PIP;LCK;EDEM2 |
protein binding | MAGEB2;DEF6;CDCA5;ZFAND6;CYP1A1;SPZ1;CDH23;PLIN3;NCOR2 |
receptor binding | ADM;Fert2;GSDMA2;HRG;KNG1;LPL;TNFSF13;Ifnl2;P2RX7 |
serine-type endopeptidase activity | F7I;PRSS54;TMPRSS11F;CELA2A;ST14A;PRSS33;MST1;EGFBP2;PRSS39 |
serine-type peptidase activity | PARLA;EGFBP2;FAP;TMPRSS2;F9B;ELA2L;TMPRSS12;MCPT8;TMPRSS7 |
F7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F7 here. Most of them are supplied by our site. Hope this information will be useful for your research of F7.
F3; capsh_ade05; DMWD; USP49; UIMC1; IKBKG; RCHY1; ALB; BECN1; SLX4; GABARAPL1
- Q&As
- Reviews
Q&As (5)
Ask a questionFactor VII's role in the coagulation cascade ensures rapid initiation of clot formation, preventing excessive bleeding and contributing to hemostasis.
Factor VII is a key player in the extrinsic pathway, where it forms a complex with tissue factor to activate factor X, initiating the cascade leading to thrombin generation.
Factor VII is activated through a proteolytic cleavage, converting it into its active form (VIIa). This activation is regulated by tissue factor and other coagulation factors.
F7 deficiency results in impaired blood clotting, leading to a bleeding disorder known as coagulation factor VII deficiency. This condition can manifest in varying degrees of severity.
Factor VII is activated to its enzymatically active form (factor VIIa) and initiates the coagulation cascade by activating factor X, ultimately leading to the formation of a stable blood clot.
Customer Reviews (3)
Write a reviewQuick turnaround—this product arrived swiftly, facilitating our research.
Exceptional quality and precision—our lab relies on this protein consistently.
Invaluable assistance from customer service—professional and responsive.
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