F2R
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Official Full Name
Coagulation factor II (thrombin) receptor
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Overview
There are three known thrombin receptors termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). These receptors are members of the 7 transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Thrombin, a serine protease, binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand corresponding to the new N-terminus, SFLLRN, is then unmasked, binding to the second extracellular loop of the receptor and activating it. -
Synonyms
Coagulation factor II receptor; CF2R; Coagulation factor II (thrombin) receptor; F2R; HTR; PAR 1; PAR-1; PAR1; Protease activated receptor 1; Proteinase activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor; TR;
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F2R involved in several pathways and played different roles in them. We selected most pathways F2R participated on our site, such as Rap signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with F2R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | PDGFD;MET;GNAO1;FLT1;RAP1GAP;RAPGEF1;GNAI1;FGF16;PIK3CG |
| Calcium signaling pathway | TNNC1B;CAMK2G;AVPR1B;Adcy4;CHRM2;GRIN1;P2RX4A;PLCB4;VDAC2 |
| cAMP signaling pathway | HCN2;ACOX1;PTGER3;MAPK8;MAP2K2;ARAP3;GNAI3;CREB3L3;RELA |
| Phospholipase D signaling pathway | PIK3CG;SHC3;DGKD;SOS1;CYTH1;MAP2K1;PPAP2C;RHEB;SHC1 |
| Neuroactive ligand-receptor interaction | P2RX4;GABRR3A;GLRA1;TAAR8B;GLP2R;TRY;LPAR2;RXFP4;MC5RA |
| Endocytosis | KIF5C;HSPA2;VPS26BL;ERBB3B;SH3GLB1;DNM2B;DNM3;KITA;CHMP2B |
| PIK-Akt signaling pathway | HGF;THBS3;FGF22;IGF1R;ITGA9;FGF19;PIK3R3;RPTOR;FGF13 |
| Complement and coagulation cascades | SERPING1;C4BPA;C1QB;PLAT;VWF;C2;PROC;SERPINA1D;C3 |
| Platelet activation | P2RY1;PIK3R3;PRKACG;ITPR3;ACTG1;SYK;AKT1;ACTB;FERMT3 |
| Regulation of actin cytoskeleton | RRAS;BCAR1;SRC;FGF18;VAV2;MSNA;RASSF7;CHRM5B;PPP1CAA |
| Pathways in cancer | WNT8A;RARA;GNAI2;CCND1;PRKACB;MMP9;WNT3;MDM2;FLT3 |
F2R has several biochemical functions, for example, G-protein alpha-subunit binding, G-protein beta-subunit binding, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F2R itself. We selected most functions F2R had, and list some proteins which have the same functions with F2R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein alpha-subunit binding | RIC8B;CRHR1;RIC8A;HTR2A;NUCB1;F2R;RGS19;IGF1R;ARHGEF11 |
| G-protein beta-subunit binding | F2R;RASD2;F2RL1;RGS11;CCT5;RGS7;OPRM1;GNG2;RGS9 |
| G-protein coupled receptor activity | CXCR3.2;GPR149;GRIN1A;TAS2R202;GPR52;PTGER2B;TAAR12B;TAAR14J;TAS1R2.2 |
| protein binding | PALB2;ZNF625;AAK1;FHL5;VAV2;SLPI;NSMCE2;HACE1;SCRN2 |
| receptor binding | SRI;TRIM24;CAV1;KNG1;PVRL1A;PGR;TNFSF14;ADAM10;WNT4A |
| thrombin receptor activity | F2RL1.2;F2RL1;GP1BA;F2RL2;F2RL1.1;F2R |
F2R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F2R here. Most of them are supplied by our site. Hope this information will be useful for your research of F2R.
PROCR; MMP1; CAPN1; GNA13; TMED2; purL; CHRD; ATP13A2; CAV1
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