f2r

Home / Products / f2r

f2r

Official Full Name Coagulation factor II (thrombin) receptor
Background There are three known thrombin receptors termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). These receptors are members of the 7 transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Thrombin, a serine protease, binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand corresponding to the new N-terminus, SFLLRN, is then unmasked, binding to the second extracellular loop of the receptor and activating it.
Synonyms Coagulation factor II receptor; CF2R; Coagulation factor II (thrombin) receptor; F2R; HTR; PAR 1; PAR-1; PAR1; Protease activated receptor 1; Proteinase activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor; TR
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human F2R-367H Recombinant Human F2R Protein, His-tagged HEK293 His
    Human F2R-2116HCL Recombinant Human F2R cell lysate N/A
    Human F2R-31176TH Recombinant Human F2R Wheat Germ N/A
    Human F2R-3613H Recombinant Human F2R Protein, GST-tagged Wheat Germ GST
    Human F2R-375H Recombinant Human F2R Mammalian Cell His
    Mouse F2R-5409M Recombinant Mouse F2R Protein Mammalian Cell His
    Zebrafish F2R-6482Z Recombinant Zebrafish F2R Mammalian Cell His
    Kit-0927 TR-FRET PPAR alpha Competitive Binding Assay Kit, rabbit N/A
    Kit-1232 F2R (PAR1) CHO-K1 β-Arrestin GPCR Assay Kit N/A

    f2r involved in several pathways and played different roles in them. We selected most pathways f2r participated on our site, such as Rap signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with f2r were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway INSR; NGF; ITGAL; FGF6; INS1; ITGB2L; PRKD3; FIGF; MAP2K6; FLT4
    Calcium signaling pathway PLCB2; ATP2A3; P2RX1; NOS2B; GRM1; EDNRA; GRM5; HTR7; TACR1; SLC25A31
    cAMP signaling pathway ATP1A1; HTR4; MC2R; SOX9; Adcy4; HCAR3; GABBR2; RHOA; ROCK2; RYR2
    Phospholipase D signaling pathway CYTH2; F2R; AKT2; MTOR; AVPR2; NRAS; PLCB3; PLCG2; LPAR6; GRM7
    Neuroactive ligand-receptor interaction AGTR1B; NPBWR2; GHRHR; GABRA3; TAAR14J; HTR1F; NPY1R; DRD2L; TAAR11; TAAR14I
    Endocytosis RAB4A; PIP5K1B; RAB5B; PML; SNX1B; WIPF1A; DNM1B; CSF1RA; ITCH; VPS4A
    PIK-Akt signaling pathway IFNA12; INS; CASP9; IL7R; MAPK3; G6PC2; IFNA21; ITGA4; CCND2; LPAR6
    Complement and coagulation cascades CPB2; SERPINA1D; CD59A; FGB; THBD; C5; C1QA; SERPINA1E; CR1L; CD59
    Platelet activation ITGA2; MYLK; ARHGEF12; GP1BA; FCER1G; MAPK11; PRKACB; ACTG1; MAPK1; BTK
    Regulation of actin cytoskeleton ARPC5A; MYL10; PIK3CA; PPP1R12C; CHRM2A; FN1; MYLK; PTK2AA; FGFR4; ITGAE
    Pathways in cancer PDGFB; GNAI1; Ar; FZD6; GNG2; GNB2; GLI3; LPAR3; IKBKB; FGF3

    f2r has several biochemical functions, for example, G-protein alpha-subunit binding, G-protein beta-subunit binding, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by f2r itself. We selected most functions f2r had, and list some proteins which have the same functions with f2r. You can find most of the proteins on our site.

    Function Related Protein
    G-protein alpha-subunit binding DRD1A; OPRM1; F2RL1; DRD1; ADRB2; LPAR1; RIC8; IGF1R; PPP5C; RIC8B
    G-protein beta-subunit binding RGS11; F2RL1; F2R; RASD2; RGS7; OPRM1; GNG13; GNG2; RGS9; CCT5
    G-protein coupled receptor activity TAAR12B; GPR31B; GNRHR3; GNRHR2; TAAR12F; FZD5; COR1; OLFR469; MTNR1BA; TAAR13D
    protein binding PRMT1; DRG1; CD47; UPF3A; SIPA1L2; ATF1; RHBDL1; Rhox5; LIMD2; STYX
    receptor binding CADM2; CD86; BMP3; ARPP19A; DPP4; Fert2; HSD17B4; MATK; FRK; PPP2R4
    thrombin receptor activity F2RL1.2; GP1BA; F2RL1.1; F2R; F2RL1; F2RL2

    f2r has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with f2r here. Most of them are supplied by our site. Hope this information will be useful for your research of f2r.

    PROCR; MMP1; CAPN1; GNA13; TMED2; purL; CHRD; ATP13A2; CAV1

    Sung, TS; Kim, HU; et al. Protease-activated receptors modulate excitability of murine colonic smooth muscles by differential effects on interstitial cells. JOURNAL OF PHYSIOLOGY-LONDON 593:1169-1181(2015).
    D'Asti, E; Kool, M; et al. Coagulation and angiogenic gene expression profiles are defined by molecular subgroups of medulloblastoma: evidence for growth factor-thrombin cross-talk. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 12:1838-1849(2014).

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved.