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Official Full Name F11 receptor
Background Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5 alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Synonyms F11R; F11 receptor; JAM1, junctional adhesion molecule 1; junctional adhesion molecule A; CD321; JAM 1; JAM A; JAMA; JCAM; PAM 1; platelet F11 receptor; platelet adhesion molecule 1; junctional adhesion molecule 1; JAM; KAT; JAM1; PAM-1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • hIgG1
    • hIgG4
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human F11R-301280H Recombinant Human F11R protein, GST-tagged E.coli GST
    Human F11R-181H Recombinant Human F11R Protein HEK293 N/A
    Human F11R-2741HCL Recombinant Human F11R cell lysate Human Cell N/A
    Human F11R-3604H Recombinant Human F11R Protein Wheat Germ N/A
    Human F11R-3605H Recombinant Human F11R Protein, GST-tagged Wheat Germ GST
    Human F11R-6491H Recombinant Human F11R Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human F11R-6785H Recombinant Human F11 Receptor, His-tagged E.coli His
    Human F11R-69H Recombinant Human F11R, Fc tagged Human Cell Fc
    Human F11R-788H Recombinant Human F11 Receptor, His-tagged Human Cell His
    Human F11R-790H Recombinant Human F11R, His tagged Human Cell His
    Human F11R-961H Recombinant Human F11R Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse F11r-1057M Recombinant Mouse F11r Protein, Fc Chimera Mammalian cells Fc
    Mouse F11R-2127MCL Recombinant Mouse F11R cell lysate Human Cell N/A
    Mouse F11r-2899M Recombinant Mouse F11r Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse F11r-4032M Recombinant Mouse F11r, Fc tagged Human Cell Fc
    Rat F11R-1437RCL Recombinant Rat F11R cell lysate Human Cell N/A
    Rat F11R-2175R Recombinant Rat F11R Protein Mammalian Cell His
    Rat F11r-7470R Recombinant Rat F11r, Fc tagged Human Cell Fc
    Rat F11r-8744R Recombinant Rat F11r, His tagged Human Cell His
    Rhesus Macaque F11R-1530R Recombinant Rhesus monkey F11R Protein, His-tagged Mammalian Cell His
    Rhesus monkey F11R-1731R Recombinant Rhesus Monkey F11R Protein HEK293 N/A
    Rhesus monkey F11R-1732R Recombinant Rhesus Monkey F11R Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey F11R-1733R Recombinant Rhesus Monkey F11R Protein, hIgG4-tagged HEK293 hIgG4
    Chicken F11R-3682C Recombinant Chicken F11R Mammalian Cell His

    F11R involved in several pathways and played different roles in them. We selected most pathways F11R participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with F11R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) VCAN; PECAM1; F11R; CNTN1; GLYCAM1; Itgam&Itgb2; JAM2A; NCAM1A; ITGB1B.2; BLA
    Tight junction PPP2R1A; CDC42L2; SHROOM2; CLDN2; CLDN8; MYLPFA; CLDN5A; CLDN9; KRAS; ASH1L
    Leukocyte transendothelial migration ROCK2; CLDN5; ESAM; PTK2B; MMP9; CXCL12; PIK3CG; Itgam&Itgb2; NCF4; NOX3
    Epithelial cell signaling in Helicobacter pylori infection LYN; ATP6V1D; SRC; CXCL1; ATP6V1H; CCL5; PLCG1; PLCG2; PAK1; MAP3K14

    F11R has several biochemical functions, for example, PDZ domain binding, protein binding, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F11R itself. We selected most functions F11R had, and list some proteins which have the same functions with F11R. You can find most of the proteins on our site.

    Function Related Protein
    PDZ domain binding CIT; GRASP; SLC26A6; MAP2K2; LNX2; KIDINS220; CXXC4; SLC9A3R1; GNG5; SLC22A5
    protein binding COG7; MAPRE2; DUSP14; FAAH; GRIA1; ZCCHC12; CD80; LEPR; TBPL1; TSGA10
    virus receptor activity SLC20A2; LAMP1; IDE; F11R; ITGB5; SCARB1; HSPA1B; MRC1; DAG1; SLC52A2

    F11R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F11R here. Most of them are supplied by our site. Hope this information will be useful for your research of F11R.


    Babinska, A; Clement, CC; et al. Development of New Antiatherosclerotic and Antithrombotic Drugs Utilizing F11 Receptor (F11R/JAM-A) Peptides. BIOPOLYMERS 102:322-334(2014).
    Schmitt, MMN; Fraemohs, L; et al. Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution. ATHEROSCLEROSIS 234:254-264(2014).

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